TNF-α Plus IL-1β Induces Opposite Regulation of Cx43 Hemichannels and Gap Junctions in Mesangial Cells through a RhoA/ROCK-Dependent Pathway

Autor: Claudia M. Lucero, Lucas Marambio-Ruiz, Javiera Balmazabal, Juan Prieto-Villalobos, Marcelo León, Paola Fernández, Juan A. Orellana, Victoria Velarde, Juan C. Sáez, Gonzalo I. Gómez

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 17, p 10097 (2022)

Connexin 43 (Cx43) is expressed in kidney tissue where it forms hemichannels and gap junction channels. However, the possible functional relationship between these membrane channels and their role in damaged renal cells remains unknown. Here, analysi

Externí odkaz: https://doaj.org/article/9808bb4a8d1c4acca66f7a5355f731a9

Astroglial Hemichannels and Pannexons: The Hidden Link between Maternal Inflammation and Neurological Disorders

Autor: Javiera Balmazabal, Juan Prieto-Villalobos, Andrés Liberona, Juan A. Orellana, Gigliola Ramírez, Tanhia F. Alvear, Gonzalo Gomez, Carla A. Inostroza, Claudio J. Martínez-Araya, Claudia Lucero

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9503, p 9503 (2021)

Maternal inflammation during pregnancy causes later-in-life alterations of the offspring’s brain structure and function. These abnormalities increase the risk of developing several psychiatric and neurological disorders, including schizophrenia, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707d367a4ef839981cfedbbbb5aa5155
https://doi.org/10.3390/ijms22179503