Advanced Imaging Methodology in Bacterial Biofilms with a Fluorescent Enzymatic Sensor for pepN Activity

Autor: Javier Valverde-Pozo, Jose M. Paredes, María Eugenia García-Rubiño, María Dolores Girón, Rafael Salto, Jose M. Alvarez-Pez, Eva M. Talavera

Publikováno v: Biosensors, Vol 14, Iss 9, p 424 (2024)

This research explores the use of the pepN activity fluorescent sensor DCM-Ala in bacterial biofilms, emphasizing its significance due to the critical role of biofilms in various biological processes. Advanced imaging techniques were employed to visu

Externí odkaz: https://doaj.org/article/0fa93c6092c64c4297af843e2a64e590

Ratiometric Two-Photon Near-Infrared Probe to Detect DPP IV in Human Plasma, Living Cells, Human Tissues, and Whole Organisms Using Zebrafish

Autor: Javier Valverde-Pozo, Jose M. Paredes, Thomas J. Widmann, Carmen Griñan-Lison, Giada Ceccarelli, Antimo Gioiello, M. Eugenia Garcia-Rubiño, Juan A. Marchal, Jose M. Alvarez-Pez, Eva M. Talavera

Publikováno v: ACS Sensors. 8:1064-1075

DPP IV, otherwise known as CD26 lymphocyte T surface antigen, is a transmembrane glycoprotein also found in circulation in the blood. It plays an important role in several processes like glucose metabolism and T-cell stimulation. Moreover, it is over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598225e6d9ddfb8c811b89f373b77859
https://doi.org/10.1021/acssensors.2c02025

PERSONAL ATTENTION PROGRAM TO UNIVERSITY STUDENTS WITH SPECIAL EDUCATIONAL NEEDS

Autor: María José Alférez, Beatriz Clares Naveros, Ana Conejo García, Olga Cruz López, Emilio García Fernández, Rafael Jesús Giménez Martínez, María Del Carmen González García, Enrique González Muñoz, Josefa María González Pérez, Juan Antonio González Vera, Alberto Molinero García, Ana Isabel Del Moral García, Celia Monteagudo Sánchez, Ricardo Navarrete Casas, Francisco Ocaña Peinado, José Manuel Paredes Martínez, Miguel Romero Pérez, Belén Rubio Ruiz, María José Ruedas Rama, Manuel Sánchez Polo, Javier Valverde Pozo, Rosa Castilla Ríos, Carlos Francisco García Jiménez, Antonio Lozano Ortega, Ángel Martínez Avilés, Alberto González Muñoz, Lidya González Robles, Javier Sepúlveda Villodres, Eva María Talavera Rodríguez

Publikováno v: INTED2023 Proceedings.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06ed6a5442338077c486f97a2331f224
https://doi.org/10.21125/inted.2023.0143

New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action

Autor: Pilar M. Luque-Navarro, M. Paz Carrasco-Jiménez, Laura Goracci, Jose M. Paredes, Laura Espinar-Barranco, Javier Valverde-Pozo, Archimede Torretta, Emilio Parisini, Elena Mariotto, Chiara Marchioro, Alejandro Laso, Carmen Marco, Giampietro Viola, Daniela Lanari, Luisa Carlota López Cara

Publikováno v: European Journal of Medicinal Chemistry. 246:115003

Since the identification of human choline kinase as a protein target against cancer progression, many compounds have been designed to inhibit its function and reduce the biosynthesis of phosphatidylcholine. Herein, we propose a series of bioisosteric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3560e60f449fae878300b31536a32322
https://doi.org/10.1016/j.ejmech.2022.115003

New Red-Emitting Chloride-Sensitive Fluorescent Protein with Biological Uses

Autor: Jose M. Paredes, Laura Espinar-Barranco, Virginia Puente-Muñoz, Jose D. Vílchez, María D. Girón, Javier Valverde-Pozo, Daniele Arosio, Rafael Salto

Publikováno v: ACS Sensors
ACS sensors Online 6 (2021): 2563–2573. doi:10.1021/acssensors.1c00094
info:cnr-pdr/source/autori:Salto R.; Giron M.D.; Puente-Munoz V.; Vilchez J.D.; Espinar-Barranco L.; Valverde-Pozo J.; Arosio D.; Paredes J.M./titolo:New Red-Emitting Chloride-Sensitive Fluorescent Protein with Biological Uses/doi:10.1021%2Facssensors.1c00094/rivista:ACS sensors Online/anno:2021/pagina_da:2563/pagina_a:2573/intervallo_pagine:2563–2573/volume:6
Digibug. Repositorio Institucional de la Universidad de Granada
instname

This work was financially supported by CTQ2017-85685-R, CTQ2017-85454-C2-1-P, and CTQ2017-86125-P (MICIU/AEI/ERDF). J.M.P. and J.D.V. thank UEQ for funding. J.V.P. is supported by an FPU fellowship (FPU17/04749). D.A. was supported by the Italian Cys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf12517c4057564ae52fef0a871fdc1
https://pubmed.ncbi.nlm.nih.gov/34148347