Glucose homeostasis changes and pancreatic β-cell proliferation after switching to cyclosporin in tacrolimus-induced diabetes mellitus

Autor: Ana Elena Rodríguez-Rodríguez, Javier Triñanes, Esteban Porrini, Silvia Velázquez-García, Cecilia Fumero, María Jose Vega-Prieto, María Luisa Díez-Fuentes, Sergio Luis Lima, Eduardo Salido, Armando Torres

Publikováno v: Nefrología (English Edition), Vol 35, Iss 3, Pp 264-272 (2015)

Background: Switching to cyclosporin A may result in a reversion of tacrolimus-induced diabetes mellitus. However, mechanisms underlying such a reversion are still unknown. Methods: Obese Zucker rats were used as a model for tacrolimus-induced diabet

Externí odkaz: https://doaj.org/article/3930df58a4424d01afe0ed9e139ced95

Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger beta-Cell Failure

Autor: Françoise Carlotti, Javier Triñanes, Maaike Hanegraaf, Nathalie Groen, Cinthia B. Drachenberg, Aiko P. J. de Vries, Eelco J.P. de Koning, Ton J. Rabelink, Ana Rodríguez-Rodríguez, Esteban Porrini, Peter ten Dijke

Publikováno v: Diabetes, 69(2), 193-204. AMER DIABETES ASSOC
Diabetes. American Diabetes Association Inc.

Active maintenance of beta-cell identity through fine-tuned regulation of key transcription factors ensures beta-cell function. Tacrolimus, a widely used immunosuppressant, accelerates onset of diabetes after organ transplantation, but underlying mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d0c6d1f1c6ea811a75013e0829dbce
https://hdl.handle.net/1887/3181509

Vascular Damage and Kidney Transplant Outcomes: An Unfriendly and Harmful Link

Autor: Domingo Hernández, Juana Alonso-Titos, Eulalia Palma, Javier Triñanes, Armando Torres, Ana Duarte, Ana María Armas, Eduardo Salido, Pedro Ruiz-Esteban, M. Gonzalez-Molina

Publikováno v: The American Journal of the Medical Sciences. 354:7-16

Kidney transplant (KT) is the treatment of choice for most patients with chronic kidney disease, but this has a high cardiovascular mortality due to traditional and nontraditional risk factors, including vascular calcification. Inflammation could pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c756474f0cfb4d095455d40f2ee3b0
https://doi.org/10.1016/j.amjms.2017.01.004

Cambios en la homeostasis de la glucosa y la proliferación de la célula beta pancreática tras el cambio a ciclosporina en la diabetes inducida por tacrolimus

Autor: Esteban Porrini, María Luisa Díez-Fuentes, Sergio Luis Lima, Eduardo Salido, Ana Rodríguez-Rodríguez, Cecilia Fumero, Silvia Velazquez-Garcia, María José de la Vega-Prieto, Javier Triñanes, Armando Torres

Publikováno v: Nefrología, Vol 35, Iss 3, Pp 264-272 (2015)
Nefrología (Madrid) v.35 n.3 2015
SciELO España. Revistas Científicas Españolas de Ciencias de la Salud
instname

ResumenAntecedentesEl cambio a ciclosporinaA podría revertir la diabetes inducida por tacrolimus. Sin embargo, los mecanismos de esta reversibilidad se desconocen.MétodosUsamos como modelo de diabetes inducida por tacrolimus las ratas Zucker obesas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a764e85fdf9f91b810c8065b88dc951

The Higher Diabetogenic Risk of Tacrolimus Depends on Pre-Existing Insulin Resistance. A Study in Obese and Lean Zucker Rats

Autor: Ana Rodríguez-Rodríguez, E. Salido Ruiz, M. L. Diez Fuentes, M. J. Vega Prieto, S. Velazquez-Garcia, Esteban Porrini, Javier Triñanes, Armando Torres, Miguel Arévalo

Publikováno v: American Journal of Transplantation. 13:1665-1675

Insulin resistance may interact with calcineurin inhibitors, enhancing the diabetogenic effect of tacrolimus compared with cyclosporine-A. We studied both drugs in insulin-resistant animals: obese Zucker rats (n = 45), and insulin-sensitive animals:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc4f5e40b9ba17825658bfd533823ef
https://doi.org/10.1111/ajt.12236