Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Javier Sanchez-Padilla"'
Autor:
Ema Ilijic, Dan Galtieri, Javier Sanchez-Padilla, David L. Wokosin, Jyothisri Kondapalli, Jaime N. Guzman, Paul T. Schumacker, D. James Surmeier, Ben Yang
Publikováno v:
Journal of Clinical Investigation. 128:2266-2280
The ability of the Cav1 channel inhibitor isradipine to slow the loss of substantia nigra pars compacta (SNc) dopaminergic (DA) neurons and the progression of Parkinson’s disease (PD) is being tested in a phase 3 human clinical trial. But it is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedc371902f147fc1268934dcedd2e53
https://doi.org/10.1172/jci95898
https://doi.org/10.1172/jci95898
Publikováno v:
Neuroscience. 198:221-231
Parkinson’s disease (PD) is the second most common neurodegenerative disease in developed countries. The core motor symptoms are attributable to the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Why these ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caac0e3e9aa44b4d23810368c1600b47
https://doi.org/10.1016/j.neuroscience.2011.08.045
https://doi.org/10.1016/j.neuroscience.2011.08.045
Publikováno v:
The Journal of Neuroscience. 29:11011-11019
Dopaminergic neurons of the substantia nigra pars compacta are autonomous pacemakers. This activity is responsible for the sustained release of dopamine necessary for the proper functioning of target structures, such as the striatum. Somatodendritic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dc82f5d89c38baf8a388ddcf9bfe81
https://doi.org/10.1523/jneurosci.2519-09.2009
https://doi.org/10.1523/jneurosci.2519-09.2009
Autor:
Ema Ilijic, Javier Sanchez-Padilla, Jaime N. Guzman, Daniel J. Galtieri, Simon Schieber, Paul T. Schumacker, D. James Surmeier, Wolfgang H. Oertel, Jyothisri Kondapalli, David L. Wokosin, Ben Yang
Publikováno v:
Nature neuroscience. 17(6)
Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d04b21212eadf11b03df931e310a3b9
https://pubmed.ncbi.nlm.nih.gov/24866040
https://pubmed.ncbi.nlm.nih.gov/24866040
Publikováno v:
Antioxidantsredox signaling. 14(7)
Parkinson's disease (PD) is a major world-wide health problem afflicting millions of the aged population. Factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and environmental toxins, have dominated publi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6ed3b9b997b26f36b39ed0989197b7
https://pubmed.ncbi.nlm.nih.gov/20712409
https://pubmed.ncbi.nlm.nih.gov/20712409
Publikováno v:
Progress in brain research. 183
The factors governing neuronal loss in Parkinson's disease (PD) are the subject of continuing speculation and experimental study. In recent years, factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eca05dedcc032c3afc9389f2760c4913
https://pubmed.ncbi.nlm.nih.gov/20696315
https://pubmed.ncbi.nlm.nih.gov/20696315
Autor:
Jaime N. Guzman, Paul T. Schumacker, Ema Ilijic, Javier Sanchez-Padilla, Jyothisri Kondapalli, David L. Wokosin, D. James Surmeier
Publikováno v:
Nature
Parkinson’s disease is a pervasive, ageing-related neurodegenerative disease the cardinal motor symptoms of which reflect the loss of a small group of neurons, the dopaminergic neurons in the substantia nigra pars compacta1 (SNc). Mitochondrial oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4d4c6294b64c63abf5e72e55a62f99
https://pubmed.ncbi.nlm.nih.gov/25993967
https://pubmed.ncbi.nlm.nih.gov/25993967
Parkinson's disease (PD) is the second most common neurodegenerative disease in developed countries. The core motor symptoms are attributable to the degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). Why these neurons,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50cf4af1cbaa80c0a3dc2198a37334c
https://europepmc.org/articles/PMC3235732/
https://europepmc.org/articles/PMC3235732/
The factors governing neuronal loss in Parkinson's disease (PD) are the subject of continuing speculation and experimental study. In recent years, factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04a63547f511e60ca7e0e5b7278b4024
https://doi.org/10.1016/s0079-6123(10)83004-3
https://doi.org/10.1016/s0079-6123(10)83004-3