From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors.

Autor: Ana Zafra Ruano, Elisa Cilia, José R Couceiro, Javier Ruiz Sanz, Joost Schymkowitz, Frederic Rousseau, Irene Luque, Tom Lenaerts

Publikováno v: PLoS Computational Biology, Vol 12, Iss 5, p e1004938 (2016)

Src Homology 3 domains are ubiquitous small interaction modules known to act as docking sites and regulatory elements in a wide range of proteins. Prior experimental NMR work on the SH3 domain of Src showed that ligand binding induces long-range dyna

Externí odkaz: https://doaj.org/article/17fd4d566c184f2a9d440fd466e6f280

A calorimetric and structural analysis of cooperativity in the thermal unfolding of the PDZ tandem of human Syntenin-1

Autor: Jose C. Martinez, Javier Ruiz-Sanz, María J. Resina, Fernando Montero, Ana Camara-Artigas, Irene Luque

Publikováno v: International Journal of Biological Macromolecules. 242:124662

Syntenin-1 is a multidomain protein containing a central tandem of two PDZ domains flanked by two unnamed domains. Previous structural and biophysical studies show that the two PDZ domains are functional both isolated and in tandem, occurring a gain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91da27674c7e39bd239ae513a90d14de
https://doi.org/10.1016/j.ijbiomac.2023.124662

Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families

Autor: Jose C. Martinez, Francisco Castillo, Javier Ruiz-Sanz, Javier Murciano-Calles, Ana Camara-Artigas, Irene Luque

Publikováno v: Protein Design and Structure ISBN: 9780323992299

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe9bd778946bc75cc864531899268b82
https://doi.org/10.1016/bs.apcsb.2021.12.002

The FDA-Approved Antiviral Raltegravir Inhibits Fascin1-Dependent Invasion of Colorectal Tumor Cells In Vitro and In Vivo

Autor: Ángel Bernabé-García, María Luisa Cayuela-Fuentes, Manuel Bernabé-García, Pablo Conesa-Zamora, Irene Luque, Horacio Pérez-Sánchez, Begoña Alburquerque-González, Francisco J. Nicolás, Javier Ruiz-Sanz, Silvia Montoro-García, Leonardo Gonnelli, Enrico Luchinat, Lucia Banci, Jorge Peña-García, Fernando F López-Calderón

Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cancers, Vol 13, Iss 861, p 861 (2021)
Cancers
Volume 13
Issue 4

Simple Summary: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. Serrated adenocarcinoma (SAC) has been recently recognized by the WHO as a histological CRC with bad prognosis. Consistent with previous evidence,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e89816bc00310824e9253ea01139a7d
https://pubmed.ncbi.nlm.nih.gov/33670655

Approaching the thermodynamic view of protein folding through the reproduction of Anfinsen's experiment by undergraduate physical biochemistry students

Autor: Eva S. Cobos, Javier Ruiz-Sanz, Jose C. Martinez, Andres Fernandez-Reche, Irene Luque

Publikováno v: Biochemistry and Molecular Biology Education. 46:262-269

In 1972 Christian B. Anfinsen received the Nobel Prize in Chemistry for "…his work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation." The understanding of this principle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::141a9ff490dc751f28835ea2a9704faa
https://doi.org/10.1002/bmb.21107