Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Javier Rodriguez-Centeno"'
Autor:
Jose I. Bernardino, Belen Alejos, Javier Rodriguez-Centeno, Andrés Esteban-Cantos, Beatriz Mora-Rojas, Rocío Montejano, Rosa De Miguel, Marta Montero-Alonso, Oskar Ayerdi, Cristina Hernández-Gutierrez, Adriá Curran, Jose R. Arribas, Berta Rodés
Publikováno v:
Microorganisms, Vol 11, Iss 7, p 1818 (2023)
We investigated whether blood telomere length (TL), epigenetic age acceleration (EAA), and soluble inflammatory monocyte cytokines are associated with cardiovascular events or diabetes (DM) in people living with HIV (PLHIV). This was a case–control
Externí odkaz:
https://doaj.org/article/9a2bf89512b0453db6f114a2b8aeb4ac
Autor:
Mathieu Chalouni, Javier Rodriguez-Centeno, Assia Samri, Julian Blanco, Natalia Stella-Ascariz, Cedrick Wallet, Hernando Knobel, David Zucman, Belen Alejos Ferreras, Brigitte Autran, Rodolphe Thiebaut, François Raffi, Jose Ramon Arribas, NEAT 001/ANRS 143 Trial Study Group
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0230772 (2020)
In 31 participants who started first-line antiretroviral therapy in the NEAT 001/ANRS 143 clinical trial, we found after 96 weeks a statistically significant increase in blood telomere length (TL) of 0.04 (T/S Ratio) (p = 0.03). This increase was pos
Externí odkaz:
https://doaj.org/article/2309cd4b9e014dda91c54fe29d0fccbe
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222909 (2019)
Telomeres are nucleo-protein structures that protect the ends of eukaryotic chromosomes. They are not completely synthesized during DNA replication and are elongated by specific mechanisms. The structure of the telomeres and the elongation mechanism
Externí odkaz:
https://doaj.org/article/23a40f67d25c418b8e96fb67597015cc
Publikováno v:
Cells, Vol 8, Iss 11, p 1406 (2019)
Dyskerin is a protein involved in the formation of small nucleolar and small Cajal body ribonucleoproteins. These complexes participate in RNA pseudouridylation and are also components of the telomerase complex required for telomere elongation. Dyske
Externí odkaz:
https://doaj.org/article/85880f98837d4753a3740d71a18ad9d4
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148533 (2016)
Amoebae of the Dictyostelium discoideum species form multicellular fruiting bodies upon starvation. Cyclic adenosine monophosphate (cAMP) is used as intercellular signalling molecule in cell-aggregation, cell differentiation and morphogenesis. This m
Externí odkaz:
https://doaj.org/article/8f5aaccc3283404ba03c9838aa401fdf
Autor:
Gabriel Saiz-Medrano, Rocío Montejano, Julián Nevado, Julen Cadiñanos, María Jiménez-González, Rosa de Miguel, Mario Mayoral-Muñoz, Pilar Barruz, Beatriz Mena-Garay, Berta Rodés, Andrés Esteban-Cantos, Jose R. Arribas, Javier Rodriguez-Centeno, Eulalia Valencia, Jose I Bernardino
Publikováno v:
The Journal of Infectious Diseases. 225:287-294
Background Human immunodeficiency virus (HIV) infection induces epigenetic age acceleration (EAA), but it remains unclear whether epigenetic aging continues to accelerate during successful antiretroviral therapy (ART) and prolonged virological suppre
Autor:
Stefan Esser, François Raffi, Javier Rodriguez-Centeno, Belén Alejos, Natalia Stella-Ascariz, Jose R. Arribas, Neat, Rocío Montejano, Christine Schwimmer, Cédrick Wallet, R De Miguel, C Goujard, Berta Rodés, Jose I Bernardino, R Sarmento-Castro, Andrés Esteban-Cantos
Publikováno v:
HIV Medicine
HIV Medicine, Wiley, 2019, 20 (10), pp.691-698. ⟨10.1111/hiv.12791⟩
HIV Medicine, Wiley, 2019, 20 (10), pp.691-698. ⟨10.1111/hiv.12791⟩
OBJECTIVES: Our aim was to investigate factors associated with baseline blood telomere length in participants enrolled in NEAT 001/ANRS 143, a randomized, open-label trial comparing ritonavir-boosted darunavir (DRV/r) plus raltegravir (RAL) with DRV/
Autor:
Javier Rodriguez-Centeno, Berta Rodés, Fernando Dronda, María J Pérez-Elías, Juan Berenguer, Matilde Sánchez-Conde, Zaida Jiménez, Juan Carlos López, Santiago Moreno, Fátima Brañas
Publikováno v:
Epigenomics. 11:501-509
Aim: To evaluate the association between DNA methylation and frailty in the HIV-infected population and to investigate the usefulness of assessing frailty as a clinical marker to identify age acceleration. Methods: Frailty was assessed according to F
Autor:
Rosa de Miguel, Eric Florence, François Raffi, Beatriz Mena-Garay, Pilar Barruz, Belén Alejos, Neat, Julen Cadiñanos, Andrea Antinori, Fiona Mulcahy, Jose R. Arribas, Anton Pozniak, Cédrick Wallet, Julián Nevado, Rocío Montejano, Gabriel Saiz-Medrano, Andrés Esteban-Cantos, Jose I Bernardino, Dénes Bánhegyi, Artur Martin, Berta Rodés, Javier Rodriguez-Centeno, Francisco Gayá
Publikováno v:
Lancet HIV
Lancet HIV, Elsevier, 2021, 8 (4), pp.e197-e205. ⟨10.1016/s2352-3018(21)00006-0⟩
Lancet HIV, Elsevier, 2021, 8 (4), pp.e197-e205. ⟨10.1016/s2352-3018(21)00006-0⟩
BACKGROUND: DNA methylation-based estimators of biological age are reliable biomarkers of the ageing process. We aimed to investigate a range of epigenetic ageing biomarkers in a substudy of the NEAT001/ANRS143 clinical trial, which compared ritonavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df7116f66bb481105dfcd3e6b2ffeb
https://hal.archives-ouvertes.fr/hal-03269699
https://hal.archives-ouvertes.fr/hal-03269699
Autor:
Ignacio Pérez-Valero, Francisco Arnalich, Juan González-García, Susana Monge, Jose R. Arribas, Javier Rodriguez-Centeno, Eulalia Valencia, Rosa de Miguel, Rosario Perona, Victoria Moreno, Rocío Montejano, Natalia Stella-Ascariz, Jose I Bernardino, Luz Martín-Carbonero, Berta Rodés, Belén Alejos, Andres Esteban Cantos, María Luisa Montes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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[Background]: Tenofovir is a potent inhibitor of human telomerase. The clinical relevance of this inhibition is unknown.
[Methods]: A prospective cohort of human immunodeficiency virus (HIV)–infected participants with suppressed virological re
[Methods]: A prospective cohort of human immunodeficiency virus (HIV)–infected participants with suppressed virological re