Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids

Autor: Pilar Bustamante-Madrid, Antonio Barbáchano, David Albandea-Rodríguez, Javier Rodríguez-Cobos, Nuria Rodríguez-Salas, Isabel Prieto, Aurora Burgos, Jaime Martínez de Villarreal, Francisco X. Real, José Manuel González-Sancho, María Jesús Larriba, Miguel Lafarga, Alberto Muñoz, Asunción Fernández-Barral

Publikováno v: Cell Death and Disease, Vol 15, Iss 4, Pp 1-16 (2024)

Abstract Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address these questions but studies are

Externí odkaz: https://doaj.org/article/1747eea4e0c942f3bab2ba3f194d57d3

Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

Autor: Miren Alonso-Navarro, Maria Gamella, Gemma Domínguez, Rodrigo Sanz, Javier Rodríguez-Cobos, María Jesús Fernández-Aceñero, J. Ignacio Casal, Carmen Poves, Rebeca M. Torrente-Rodríguez, María Garranzo-Asensio, Itziar Aranguren-Abeigon, José M. Pingarrón, Alberto Peláez-García, Vivian de los Ríos, Guillermo Solís-Fernández, Jana Dziaková, Ana Montero-Calle, Ana Guzman-Aranguez, Eloy Povedano, Rodrigo Barderas, Susana Campuzano, Javier Martínez-Useros

Publikováno v: Engineering, Vol 7, Iss 10, Pp 1393-1412 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Repisalud
Instituto de Salud Carlos III (ISCIII)
E-Prints Complutense. Archivo Institucional de la UCM

20 p.-9 fig.-2 tab.
Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. The 5-year survival rate of CRC patients depends on the stage at diagnosis, being higher than 80% when CRC is diagnosed in the early stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86d51ca069118b13e54f0905d1e72fc
http://www.sciencedirect.com/science/article/pii/S2095809921003258

ΔNp73, TAp73 and Δ133p53 Extracellular Vesicle Cargo as Early Diagnosis Markers in Colorectal Cancer

Autor: Mª. Isabel Prieto, Héctor Peinado, Daniel Pastor-Morate, Carmen Poves, Javier Rodríguez-Cobos, D. Viñal, Nuria Rodríguez-Salas, Gemma Domínguez, Rodrigo Barderas, María Jesús Fernández-Aceñero

Publikováno v: Cancers
Volume 13
Issue 9
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
Biblos-e Archivo. Repositorio Institucional de la UAM
Cancers, Vol 13, Iss 2240, p 2240 (2021)

© 2021 by the authors.
The early diagnosis of colorectal cancer is a key factor in the overall survival of the patients. The actual screening programs include different approaches with significant limitations such as unspecificity, high invasiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b892766e06958caf72882f4adc82e73e

ΔNp73 status in peritoneal and ovarian dissemination of appendicular adenocarcinoids (goblet cells)

Autor: M. Arranz-Alvarez, D. Viñal, Javier Rodríguez-Cobos, Nuria Rodríguez, M. Cano-Vega, J. P. Pérez, Gemma Domínguez, C. Méndez, D. Pastor, M. I. Prieto-Nieto, E. Palacios, Jorge Santos-López

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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[Introduction]: Goblet cell carcinoma (GCC) is an appendicular neoplasia representing less than 5% of all appendicular tumors, found in 0.3–0.9% of the appendectomies, 35–58% of all appendicular neoplasms, and less than 14% of malign appendix tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32d88d219e7566c2e5f2d27fc670906
http://hdl.handle.net/10261/207216

Relevance of pituitary aromatase and estradiol on the maintenance of the population of prolactin-positive cells in male mice

Autor: María José García-Barrado, Enrique J. Blanco, Deborah J. Burks, María Carmen Iglesias-Osma, Javier Rodríguez-Cobos, Leonardo Catalano-Iniesta, Virginia Sánchez-Robledo, Marta Carretero-Hernández, José Carretero

Publikováno v: STEROIDS
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname

In previous studies we demonstrated the expression of aromatase in pituitary cells. This expression is gender related, and is also associated with the presence of prolactinomas. To ascertain the relevance of aromatase in modulating the populations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd612f9476617ed662a95d21f5cc9ff
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1435