Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Javier Reig-López"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 156, Iss , Pp 113914- (2022)
Atorvastatin is the most prescribed 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor used to lower cardiovascular risk and constitutes one of the best-selling drugs world-wide. Several physiologically based pharmacokinetic (PBPK) models have
Externí odkaz:
https://doaj.org/article/e0e76fe0fc6746029913132b3aefbf9a
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 709 (2021)
Atorvastatin (ATS) is the gold-standard treatment worldwide for the management of hypercholesterolemia and prevention of cardiovascular diseases associated with dyslipidemia. Physiologically based pharmacokinetic (PBPK) models have been positioned as
Externí odkaz:
https://doaj.org/article/1b1e5b6802de4e04bb895ccbbf308462
Autor:
Javier Reig-López, María del Mar Maldonado, Matilde Merino-Sanjuan, Ailed M. Cruz-Collazo, Jean F. Ruiz-Calderón, Victor Mangas-Sanjuán, Suranganie Dharmawardhane, Jorge Duconge
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 975 (2020)
MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of
Externí odkaz:
https://doaj.org/article/5a76ba2dc99e411cbf4933a69f59f030
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 709, p 709 (2021)
Pharmaceutics, Vol 13, Iss 709, p 709 (2021)
Atorvastatin (ATS) is the gold-standard treatment worldwide for the management of hypercholesterolemia and prevention of cardiovascular diseases associated with dyslipidemia. Physiologically based pharmacokinetic (PBPK) models have been positioned as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e776bfa5a31e41015812b572a2142b7a
https://doi.org/10.3390/pharmaceutics13050709
https://doi.org/10.3390/pharmaceutics13050709
Publikováno v:
Computer methods and programs in biomedicine. 189
Background and objective The aims of this study are (i) to assess the predictive reliability of the physiologically based software PhysPK versus the well-known population approach software NONMEM for the cited semi-mechanistic PK model, (ii) to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635056ed28ec6cff576e2b63f15a9d06
https://pubmed.ncbi.nlm.nih.gov/31954235
https://pubmed.ncbi.nlm.nih.gov/31954235
Autor:
Javier Reig-López, María Elena González-Núñez, Thais Delgado-Abad, Gregorio Asensio, Jaime Martínez-Ferrer, Rossella Mello, Rafael Acerete
Publikováno v:
RSC Adv.. 4:51016-51021
Supercritical carbon dioxide (scCO2), a solvent with a zero dipole moment, low dielectric constant, and no hydrogen bonding behavior, is a suitable medium to perform the uncatalyzed electrophilic bromination of weakly activated aromatics with no inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b561f51f7bb143766769c8310d0b16af
https://doi.org/10.1039/c4ra10557e
https://doi.org/10.1039/c4ra10557e