Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Javier Mazuela"'
Autor:
Claudio Avila, Carlo Cassani, Thierry Kogej, Javier Mazuela, Sunil Sarda, Adam D. Clayton, Michael Kossenjans, Clive P. Green, Richard A. Bourne
Publikováno v:
Chemical Science. 13:12087-12099
For the discovery of new candidate molecules in the pharmaceutical industry, library synthesis is a critical step, in which library size, diversity, and time to synthesise are fundamental. In this work we propose stopped-flow synthesis as an intermed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1533c6069f247ef56619a7ca56eb302
https://doi.org/10.1039/d2sc03016k
https://doi.org/10.1039/d2sc03016k
Autor:
Javier Mazuela, Rachel H. Munday, Magnus Johansson, Stephen P. Marsden, Thomas Antonsson, Laurent Knerr
Publikováno v:
Advanced Synthesis & Catalysis. 361:578-584
High throughput experimentation (HTE) has enabled the rapid identification of ligand/precatalyst combinations that facilitate highly enantioselective hydrogenations of prochiral N‐alkyl α‐aryl ketimines containing a furyl moiety. The chiral amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1899a66b44e0b3aa212692a2de279f5
https://doi.org/10.1002/adsc.201801143
https://doi.org/10.1002/adsc.201801143
Publikováno v:
Organic Letters. 19:5541-5544
The organocatalytic asymmetric transfer hydrogenation of N-alkyl aryl imino esters for the direct synthesis of N-alkylated arylglycinate esters is reported. High yields and enantiomeric ratios were obtained, and tolerance to a diverse set of function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d0e5a64e7b4525f85a8f3acdde9f0b
https://doi.org/10.1021/acs.orglett.7b02627
https://doi.org/10.1021/acs.orglett.7b02627
Publikováno v:
Journal of the American Chemical Society
Herein we report an example of tandem oxidative acetoxylation/carbocyclization of arylallenes 1 using Pd(OAc)2. The catalytic protocol is highly selective and provides access to new C–C and C–O bonds leading to a carbocyclization. The reaction pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b240d901d1367be555b6c89d0d22002c
https://doi.org/10.1021/jacs.5b06068
https://doi.org/10.1021/jacs.5b06068
Publikováno v:
Angewandte Chemie (International Ed. in English)
An enantioselective oxidative carbocyclization-borylation of enallenes that is catalyzed by palladium(II) and a Brønsted acid was developed. Biphenol-type chiral phosphoric acids were superior co-catalysts for inducing the enantioselective cyclizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b1ca83a0e149a1d832c48fe534e012
https://doi.org/10.1002/ange.201501048
https://doi.org/10.1002/ange.201501048
Publikováno v:
ChemCatChem. 5:2410-2417
We have replaced the oxazoline group with a thiazoline moiety in one of the most successful of the phosphite–oxazoline ligand families for the Ir-catalyzed hydrogenation of minimally functionalized olefins. A small but structurally important librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b417bdf99ac2c27bb0336a6a0cae4ace
https://doi.org/10.1002/cctc.201300189
https://doi.org/10.1002/cctc.201300189
Publikováno v:
Advanced Synthesis & Catalysis. 355:2569-2583
The first successful application of phosphite-pyridine ligands in the Ir-catalyzed asymmetric hydrogenation of di- and trisubstituted olefins is developed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c84019d9de63c71afff2d17fc197570
https://doi.org/10.1002/adsc.201201017
https://doi.org/10.1002/adsc.201201017
Publikováno v:
ChemCatChem. 5:1504-1516
We have expanded the ligand design of one of the most successful phosphite-oxazoline ligands, derived from hydroxyl amino acid derivatives, in Pd-catalyzed allylic alkylation by replacing the oxazoline group with a thiazoline moiety. These phosphite-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::268152617258e4bd87dd7863a6b0a029
https://doi.org/10.1002/cctc.201200711
https://doi.org/10.1002/cctc.201200711
Publikováno v:
ChemInform. 47
This novel and efficient title reaction gives access to synthetically important functionalized indenes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e75b0e1d6048d8600ef8f3c77ca4a8
https://doi.org/10.1002/chin.201604087
https://doi.org/10.1002/chin.201604087
Publikováno v:
Journal of the American Chemical Society. 133:13634-13645
A modular set of phosphite-oxazoline (P,N) ligands has been applied to the title reaction. Excellent ligands have been identified for a range of substrates, including previously challenging terminally disubstituted olefins, where we now have reached
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90decafa8205896271ce73b9e7ead4c6
https://doi.org/10.1021/ja204948k
https://doi.org/10.1021/ja204948k