Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Javier Martinez Trufero"'
Autor:
Jordi Rubió-Casadevall, Beatriz Cirauqui Cirauqui, Javier Martinez Trufero, Maria Plana Serrahima, Almudena García Castaño, Alberto Carral Maseda, Lara Iglesias Docampo, Pedro Pérez Segura, Isaac Ceballos Lenza, Vanesa Gutiérrez Calderón, José Fuster Salvà, Carolina Pena Álvarez, Irene Hernandez, Edel del Barco Morillo, Manuel Chaves Conde, Joaquina Martínez Galán, Marisa Durán Sánchez, Vanesa Quiroga, Eugenia Ortega, Ricard Mesia
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectivesThe aim of this study was to confirm the efficacy of the ERBITAX scheme (paclitaxel 80 mg/m2 weekly and cetuximab 400 mg/m2 loading dose, and then 250 mg/m2 weekly) as first-line treatment for patients with recurrent/metastatic squamous cel
Externí odkaz:
https://doaj.org/article/2c2ce3b877f44930902325a31aadefe0
Autor:
Javier Martin-Broto, Andres Redondo, David S. Moura, Claudia Valverde, Jose Manuel Morales, Antonio Lopez-Pousa, Javier Martinez-Trufero, Antonio Gutierrez, Roberto Díaz-Beveridge, Pablo Luna, Virginia Martinez-Marin, David Marcilla, Ivan Arribas, Patricio Ledesma, Jose Antonio Lopez-Martin, Davide Di Lernia, Jorge Zamora, Nadia Hindi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In patients with progressive and symptomatic desmoid fibromatosis (DF) treatment with chemotherapy is typically prolonged, while surgery carries a high risk of relapse. Here, the authors report the results of a phase II clinical trial of short-course
Externí odkaz:
https://doaj.org/article/fa55a5db19834abd945515a13986f8dd
Autor:
David S. Moura, Maria Peña‐Chilet, Juan Antonio Cordero Varela, Ramiro Alvarez‐Alegret, Carolina Agra‐Pujol, Francisco Izquierdo, Rafael Ramos, Luis Ortega‐Medina, Francisco Martin‐Davila, Carolina Castilla‐Ramirez, Carmen Nieves Hernandez‐Leon, Cleofe Romagosa, Maria Angeles Vaz Salgado, Javier Lavernia, Silvia Bagué, Empar Mayodormo‐Aranda, Luis Vicioso, Jose Emilio Hernández Barceló, Jordi Rubio‐Casadevall, Ana deJuan, Maria Concepcion Fiaño‐Valverde, Nadia Hindi, Maria Lopez‐Alvarez, Serena Lacerenza, Joaquin Dopazo, Antonio Gutierrez, Rosa Alvarez, Claudia Valverde, Javier Martinez‐Trufero, Javier Martín‐Broto
Publikováno v:
Molecular Oncology, Vol 15, Iss 12, Pp 3691-3705 (2021)
Predictive biomarkers of trabectedin represent an unmet need in advanced soft‐tissue sarcomas (STS). DNA damage repair (DDR) genes, involved in homologous recombination or nucleotide excision repair, had been previously described as biomarkers of t
Externí odkaz:
https://doaj.org/article/97947f91b0b04bea97667fd90e9fbdb6
Autor:
Javier Martinez-Trufero, Ana Comin Orce, Pablo Gomez Mugarza, Susana Barriendos Sanz, Eugenia Ortega Izquierdo
Publikováno v:
Translational Cancer Research. 12:692-696
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::488018bbb3669c6a1632e71c53623d49
https://doi.org/10.21037/tcr-23-131
https://doi.org/10.21037/tcr-23-131
Autor:
Andrés Redondo, Joaquin Dopazo, José A López-Martin, Nadia Hindi, Javier Martin-Broto, Silvia Stacchiotti, Giovanni Grignani, Claudia Valverde, Paola Collini, Javier Martinez-Trufero, Antonio Lopez-Pousa, Lorenzo D'Ambrosio, Antonio Gutierrez, Herminia Perez-Vega, Victor Encinas-Tobajas, Enrique de Alava, Maria Peña-Chilet, Irene Carrasco-Garcia, Maria Lopez-Alvarez, David S Moura
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. As t
Externí odkaz:
https://doaj.org/article/ba0c92285ab347e788e84cf5c6815dde
Autor:
Javier Martin-Broto, Miguel Taron, Nadia Hindi, Irene Felipe-Abrio, Javier Medina, Maria Angeles Vaz, Claudia Valverde, Victor H. Villar, Rafael Ramos, Antonia Obrador-Hevia, Carlos Saus, Silvia Calabuig, Javier Martinez-Trufero, Andres Redondo, David S. Moura, Regina Alemany
Relative Expression shows the expression levels of ABCB1 and ABCC1 determined in FFPE samples after treatment (post-treatment) relatively to baseline levels (pre-treatment) in two cases (Relative expression = post-treatment/ pre-treatment). These res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2459349afd53368c97c9eaecfe9d27f7
https://doi.org/10.1158/1078-0432.22474955.v1
https://doi.org/10.1158/1078-0432.22474955.v1
Autor:
Javier Martin-Broto, Miguel Taron, Nadia Hindi, Irene Felipe-Abrio, Javier Medina, Maria Angeles Vaz, Claudia Valverde, Victor H. Villar, Rafael Ramos, Antonia Obrador-Hevia, Carlos Saus, Silvia Calabuig, Javier Martinez-Trufero, Andres Redondo, David S. Moura, Regina Alemany
Pre-Clinical studies and Phase I clinical study supplementary methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1eaa89257011f80f82de1215d0625f
https://doi.org/10.1158/1078-0432.22474964
https://doi.org/10.1158/1078-0432.22474964
Autor:
Javier Martin-Broto, Miguel Taron, Nadia Hindi, Irene Felipe-Abrio, Javier Medina, Maria Angeles Vaz, Claudia Valverde, Victor H. Villar, Rafael Ramos, Antonia Obrador-Hevia, Carlos Saus, Silvia Calabuig, Javier Martinez-Trufero, Andres Redondo, David S. Moura, Regina Alemany
SW982 cells were treated with vehicle (DMSO), nilotinib (10 µM) or doxorubicin (0.1 µM). For sequential treatment, cells were pre-treated with nilotinib (10 µM) for 72 h, and then doxorubicin (0.1 µM) was added. Cell growth was continuously monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd9ee77e58d2a70df944ab12e96d7ba
https://doi.org/10.1158/1078-0432.22474961
https://doi.org/10.1158/1078-0432.22474961
Autor:
Javier Martin-Broto, Miguel Taron, Nadia Hindi, Irene Felipe-Abrio, Javier Medina, Maria Angeles Vaz, Claudia Valverde, Victor H. Villar, Rafael Ramos, Antonia Obrador-Hevia, Carlos Saus, Silvia Calabuig, Javier Martinez-Trufero, Andres Redondo, David S. Moura, Regina Alemany
C) Values of the kinetic parameters (Vmax and Km) in the absence (vehicle, DMSO) or presence of different concentrations of nilotinib. The constants were estimated with the Michaelis-Menten equation using the GraphPad Prism program. Each value repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77f70fdc7b4a4862a86ca3572dec77f
https://doi.org/10.1158/1078-0432.22474958
https://doi.org/10.1158/1078-0432.22474958
Autor:
Sofía Ruffini Egea, Sara Elena Campos Ramírez, Natalia Pilar Pascual de la Fuente, María Luna Monreal Cepero, Fatima Mocha Campillo, Pablo Trincado Cobos, Antonio Antón Torres, Javier Martínez Trufero
Publikováno v:
Case Reports in Oncology, Vol 17, Iss 1, Pp 1252-1257 (2024)
Introduction: Malignant paragangliomas (M-PGL) are a group of neuroendocrine tumors that originate from chromaffin cells. The most common location for PGL is the head and neck, which comprise 65–70% of all PGL, and the M-PGL accounts for 0.6% of al
Externí odkaz:
https://doaj.org/article/54e617406b214294ac2f89daebbae6fc