Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Javier Martin‐Broto"'
Autor:
Sandro Pasquali, Viviana Vallacchi, Luca Lalli, Paola Collini, Marta Barisella, Cleofe Romagosa, Silvia Bague, Jean Michel Coindre, Angelo Paolo Dei Tos, Emanuela Palmerini, Vittorio Quagliuolo, Javier Martin-Broto, Antonio Lopez-Pousa, Giovanni Grignani, Jean-Yves Blay, Robert Diaz Beveridge, Elena Casiraghi, Silvia Brich, Salvatore Lorenzo Renne, Laura Bergamaschi, Barbara Vergani, Marta Sbaraglia, Paolo Giovanni Casali, Licia Rivoltini, Silvia Stacchiotti, Alessandro Gronchi
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105220- (2024)
Summary: Background: Anthracycline-based neoadjuvant chemotherapy (NAC) may modify tumour immune infiltrate. This study characterized immune infiltrate spatial distribution after NAC in primary high-risk soft tissue sarcomas (STS) and investigate ass
Externí odkaz:
https://doaj.org/article/9c4dae51bf654791ba8894a2a7b975fd
Autor:
Yi Li, Jose L. Mondaza-Hernandez, David S. Moura, Alexey S. Revenko, Angelica Tolentino, John T. Nguyen, Nam Tran, Clark A. Meyer, Jose Merino-Garcia, Rafael Ramos, Davide Di Lernia, Javier Martin-Broto, Heather N. Hayenga, Leonidas Bleris
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102154- (2024)
Solitary fibrous tumor (SFT) is a rare, non-hereditary soft tissue sarcoma thought to originate from fibroblastic mesenchymal stem cells. The etiology of SFT is thought to be due to an environmental intrachromosomal gene fusion between NGFI-A-binding
Externí odkaz:
https://doaj.org/article/5d8f5d5b1be74d249583ba786160cba2
Autor:
Jean-Yves Blay, Paolo Casali, Isabelle Ray-Coquard, Michael J. Seckl, Jourik Gietema, Wouter W. de Herder, Martyn Caplin, Heinz-Josef Klümpen, Olivier Glehen, Lucjan Wyrwicz, Robin Peeters, Lisa Licitra, Nicolas Girard, Sophie Piperno-Neumann, Ellen Kapiteijn, Ahmed Idbaih, Enrico Franceschi, Annalisa Trama, Anna-Maria Frezza, Peter Hohenberger, Nadia Hindi, Javier Martin-Broto, Johanna Schell, Muriel Rogasik, Stephane Lejeune, Kathy Oliver, Francesco de Lorenzo, Ariane Weinman
Publikováno v:
The Lancet Regional Health. Europe, Vol 39, Iss , Pp 100861- (2024)
Summary: About 500,000 patients with rare adult solid cancers (RASC) are diagnosed yearly in Europe. Delays and unequal quality of management impact negatively their survival. Since 2017, European reference networks (ERN) aim to improve the quality o
Externí odkaz:
https://doaj.org/article/4f20025ebba2481ba272e65734dc8627
Autor:
Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more c
Externí odkaz:
https://doaj.org/article/0c66d90901d244e6922dd1f9ea0a3f1f
Autor:
Jaime Carrillo-García, Serena Lacerenza, Nadia Hindi, Irene Carrasco García, Gloria Marquina, Juana María Cano Cano, Javier Martínez Trufero, Alberto Rafael Sevillano Tripero, Tania Luis García, Manuel Jorge Cuesta Rioboo, David S. Moura, Marta Renshaw, Jose L. Mondaza-Hernández, Davide Di Lernia, Antonio Gutierrez, Javier Martin-Broto
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background and objectives: Social distancing and quarantine implanted during the COVID-19 outbreak could have delayed the accession of oncologic patients to hospitals and treatments. This study analysed the management of sarcoma patients during this
Externí odkaz:
https://doaj.org/article/4176abcd3fc94b44bd8251892b02ec4b
Autor:
Javier Martin-Broto, Alicia Olarte-García, Ricardo Fernandéz-Rodríguez, Marta Ribeiro Ferreira, Irene Carrasco-García, Fernando Galvez-Montosa, Inmaculada Rincon-Perez, Javier Peinado-Serrano, Ignacio Azinovic, Laura Guzman-Gomez, Lurdes Salgado, Alberto Sevillano, Justo Ortega, Cristina Alvarez, Antonio Gutierrez, David S. Moura, Nadia Hindi
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background and objectives: Dimensional response is an unmet need in second lines of advanced soft tissue sarcomas (STS). Indeed, the three approved drugs, pazopanib, trabectedin, and eribulin, achieved an overall response rate (ORR) of less than 10%.
Externí odkaz:
https://doaj.org/article/1475ef79f82c4873859ed0806a878ff3
Autor:
Javier Martin-Broto, Claudia Valverde, Nadia Hindi, Bruno Vincenzi, Javier Martinez-Trufero, Giovanni Grignani, Antoine Italiano, Javier Lavernia, Ana Vallejo, Paolo Dei Tos, Francois Le Loarer, Ricardo Gonzalez-Campora, Rafael Ramos, Diana Hernández-Jover, Antonio Gutierrez, Cesar Serrano, Maria Monteagudo, Rocio Letón, Mercedes Robledo, David S. Moura, Marta Martin-Ruiz, Jose A. López-Guerrero, Julia Cruz, Antonio Fernandez-Serra, Jean-Yves Blay, Elena Fumagalli, Virginia Martinez-Marin
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-8 (2023)
Abstract Background Approximately 15% of adult GIST patients harbor tumors that are wild-type for KIT and PDGFRα genes (KP-wtGIST). These tumors usually have SDH deficiencies, exhibit a more indolent behavior and are resistant to imatinib. Underlyin
Externí odkaz:
https://doaj.org/article/da2ebd0056004ea28583248f6fd4476c
Autor:
Dimitris Bertsimas, Georgios Antonios Margonis, Seehanah Tang, Angelos Koulouras, Cristina R. Antonescu, Murray F. Brennan, Javier Martin-Broto, Piotr Rutkowski, Georgios Stasinos, Jane Wang, Emmanouil Pikoulis, Elzbieta Bylina, Pawel Sobczuk, Antonio Gutierrez, Bhumika Jadeja, William D. Tap, Ping Chi, Samuel Singer
Publikováno v:
EClinicalMedicine, Vol 64, Iss , Pp 102200- (2023)
Summary: Background: There are several models that predict the risk of recurrence following resection of localised, primary gastrointestinal stromal tumour (GIST). However, assessment of calibration is not always feasible and when performed, calibrat
Externí odkaz:
https://doaj.org/article/53e3b7f9ab6149689ef9632e7de90721
Autor:
Javier Martin-Broto, Andres Redondo, David S. Moura, Claudia Valverde, Jose Manuel Morales, Antonio Lopez-Pousa, Javier Martinez-Trufero, Antonio Gutierrez, Roberto Díaz-Beveridge, Pablo Luna, Virginia Martinez-Marin, David Marcilla, Ivan Arribas, Patricio Ledesma, Jose Antonio Lopez-Martin, Davide Di Lernia, Jorge Zamora, Nadia Hindi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In patients with progressive and symptomatic desmoid fibromatosis (DF) treatment with chemotherapy is typically prolonged, while surgery carries a high risk of relapse. Here, the authors report the results of a phase II clinical trial of short-course
Externí odkaz:
https://doaj.org/article/fa55a5db19834abd945515a13986f8dd
Autor:
Andrea Napolitano, David S. Moura, Nadia Hindi, José L Mondaza-Hernandez, José A. Merino-Garcia, Rafael Ramos, Gian Paolo Dagrada, Silvia Stacchiotti, Francesco Graziano, Bruno Vincenzi, Javier Martin-Broto
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Solitary fibrous tumours (SFT) are soft tissue sarcomas molecularly defined by the presence of the NAB2::STAT6 intrachromosomal fusion gene. Recently, a prospective phase II trial evaluating the role of the antiangiogenic tyrosine kinase
Externí odkaz:
https://doaj.org/article/c5c4cc310572489188a815d2101aedcc