Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Javier Martin, Gonzalez"'
Autor:
Jason Alexander Halliwell, Javier Martin-Gonzalez, Adnan Hashim, John Arne Dahl, Eva R. Hoffmann, Mads Lerdrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The timing of DNA replication in mammals is crucial for minimizing errors and influenced by genome usage and chromatin states. Replication timing in the newly formed mammalian embryo remains poorly understood. Here, we have investigated repl
Externí odkaz:
https://doaj.org/article/a28619d16a8d4704add66bf4ca318364
Autor:
Zilu Ye, Pierre Sabatier, Javier Martin-Gonzalez, Akihiro Eguchi, Maico Lechner, Ole Østergaard, Jingsheng Xie, Yuan Guo, Lesley Schultz, Rafaela Truffer, Dorte B. Bekker-Jensen, Nicolai Bache, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Mass spectrometry (MS)-based proteomics workflows typically involve complex, multi-step processes, presenting challenges with sample losses, reproducibility, requiring substantial time and financial investments, and specialized skills. Here
Externí odkaz:
https://doaj.org/article/5e6153097b5242d18061e20f48ee5094
Autor:
Sophia Engelhard, Montserrat Estruch, Shuyu Qin, Christoph A. Engelhard, Francisco G. Rodriguez-Gonzalez, Martine Drilsvik, Javier Martin-Gonzalez, Jeng-Wei Lu, David Bryder, Claus Nerlov, Joachim Weischenfeldt, Kristian Reckzeh, Kim Theilgaard-Mönch
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114475- (2024)
Summary: Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+ long-term repopulating HSCs (LT-HSCs; CD150+CD48−LSK) have a higher long-term multi-lin
Externí odkaz:
https://doaj.org/article/3dfc405563e042acaabd1378d8d20651
Autor:
Rita Silvério-Alves, Ilia Kurochkin, Anna Rydström, Camila Vazquez Echegaray, Jakob Haider, Matthew Nicholls, Christina Rode, Louise Thelaus, Aida Yifter Lindgren, Alexandra Gabriela Ferreira, Rafael Brandão, Jonas Larsson, Marella F. T. R. de Bruijn, Javier Martin-Gonzalez, Carlos-Filipe Pereira
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract In mitosis, most transcription factors detach from chromatin, but some are retained and bookmark genomic sites. Mitotic bookmarking has been implicated in lineage inheritance, pluripotency and reprogramming. However, the biological significa
Externí odkaz:
https://doaj.org/article/f8f5691509b94cb6b53110042b75708e
Autor:
Zilu Ye, Pierre Sabatier, Javier Martin-Gonzalez, Akihiro Eguchi, Maico Lechner, Ole Østergaard, Jingsheng Xie, Yuan Guo, Lesley Schultz, Rafaela Truffer, Dorte B. Bekker-Jensen, Nicolai Bache, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c178d9f094f64e408819a9a8e044d610
Autor:
Sina Atashpaz, Sara Samadi Shams, Javier Martin Gonzalez, Endre Sebestyén, Negar Arghavanifard, Andrea Gnocchi, Eliene Albers, Simone Minardi, Giovanni Faga, Paolo Soffientini, Elisa Allievi, Valeria Cancila, Angela Bachi, Óscar Fernández-Capetillo, Claudio Tripodo, Francesco Ferrari, Andrés Joaquin López-Contreras, Vincenzo Costanzo
Publikováno v:
eLife, Vol 9 (2020)
Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. He
Externí odkaz:
https://doaj.org/article/91525f93557a4ea295fba0e2fcd0a4fa
Autor:
Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H. Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D. Hickson, Andres J. Lopez-Contreras
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3274-3284 (2018)
Summary: PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investiga
Externí odkaz:
https://doaj.org/article/149a3d169b514d959965752a637b3358
Autor:
Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L. Weissman, Joan Yuan, Javier Martin-Gonzalez, David Bryder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and
Externí odkaz:
https://doaj.org/article/45468cb969c947199083e10e2b6af32d
Autor:
Javier Martin Gonzalez, Sophie M. Morgani, Robert A. Bone, Kasper Bonderup, Sahar Abelchian, Cord Brakebusch, Joshua M. Brickman
Publikováno v:
Stem Cell Reports, Vol 7, Iss 2, Pp 177-191 (2016)
Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation embryo. Here we assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity. Individual ESCs cultured in eit
Externí odkaz:
https://doaj.org/article/ebe5d83f8ce1449da14f67cbdc1edb8f
Autor:
Silas Boye Nissen, Marta Perera, Javier Martin Gonzalez, Sophie M Morgani, Mogens H Jensen, Kim Sneppen, Joshua M Brickman, Ala Trusina
Publikováno v:
PLoS Biology, Vol 15, Iss 7, p e2000737 (2017)
Early mammalian development is both highly regulative and self-organizing. It involves the interplay of cell position, predetermined gene regulatory networks, and environmental interactions to generate the physical arrangement of the blastocyst with
Externí odkaz:
https://doaj.org/article/4ca8e980dd604296bab37e5d629be73a