Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Javier Magano"'
Autor:
Aaron Baldwin, Shawn Cabral, Kris N. Jones, Jeffrey T. Kohrt, Chris Limberakis, Yiyang Liu, Javier Magano, Sebastien Monfette, Asaad Nematalla, Sami Ovaska, David W. Piotrowski, Jared L. Piper, Jeffrey W. Raggon, Benjamin A. Thuma, Liuqing Wei
Publikováno v:
Organic Process Research & Development. 27:854-865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b446554282a8d998077c9e50879f0def
https://doi.org/10.1021/acs.oprd.2c00351
https://doi.org/10.1021/acs.oprd.2c00351
Autor:
Javier Magano
Publikováno v:
Organic Process Research & Development. 26:1562-1689
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::987f9462d9d34939317b289bf395e0b8
https://doi.org/10.1021/acs.oprd.2c00005
https://doi.org/10.1021/acs.oprd.2c00005
Autor:
Taegyo Lee, Richard A. Wisdom, Amber M. Johnson, Kevin M. Knopf, Giselle P. Reyes, Bryan Li, Ruggeri Sally G, Maria S. Brown, Gerald A. Weisenburger, Lulin Wei, Adam E. Goetz, Cuong V. Lu, Kris N. Jones, Angela L. A. Puchlopek-Dermenci, Michaella A. Caporello, Samir A. Kulkarni, Mengtan Zhang, Javier Magano
Publikováno v:
Organic Process Research & Development. 25:1419-1430
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c07b7b0b7a0caed0edf5cb6b7b291c73
https://doi.org/10.1021/acs.oprd.1c00120
https://doi.org/10.1021/acs.oprd.1c00120
Autor:
Ke Wang, Bryan Li, Jason Mustakis, Ruizhi Li, Javier Magano, Mark T. Maloney, Amelie Dion, Lu Han, Ronald J. Post, David B. Damon
Publikováno v:
Industrial & Engineering Chemistry Research. 59:2409-2421
Mathematical modeling of chemical reaction kinetics has been proven to aid the development of new reactions and processes. Chemical kinetic modeling is a well-established principle in chemical engi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed53d72e20378bb7e4de2a18328dba70
https://doi.org/10.1021/acs.iecr.9b03578
https://doi.org/10.1021/acs.iecr.9b03578
Autor:
Alexander Gontcharov, Peter Jones, Steven W. Kortum, David Pattavina, Seungwon Chung, Peter Robert Rose, Jotham Wadsworth Coe, Tim L. Houck, Javier Magano, Lacey Samp, Anil Rane
Publikováno v:
Organic Process Research & Development. 23:1990-2000
A scalable synthesis of a pan-JAK inhibitor is described. The original synthesis by the Medicinal Chemistry group has been modified to develop a new protecting group strategy, a 3-step telescoped s...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7f762a2b945aa1baf327c89d57a4b24
https://doi.org/10.1021/acs.oprd.9b00253
https://doi.org/10.1021/acs.oprd.9b00253
Autor:
Anne Akin, Asaad S. Nematalla, Kevin E. Henegar, Javier Magano, Thomas A. Brandt, Liuqing Wei, Jun Xiao, David W. Piotrowski, Emma McInturff, Steve Hoagland, Jared Van Haitsma, Mark T. Barilla, Rajesh Kumar, John Brennan, Shu Yu
Publikováno v:
Organic Process Research & Development. 23:1167-1177
The synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor 3 is described. This complex structure contains a tetrazole modified by a chiral hemiaminal carbonate prodrug. A reg...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af78865fee782f9382f021ed7f6418ae
https://doi.org/10.1021/acs.oprd.9b00104
https://doi.org/10.1021/acs.oprd.9b00104
Autor:
Andrew D. Campbell, Rubén Haro, Thomas Andrew Brandt, Melodie Christensen, David B. Damon, Ke Wang, Carolina Alhambra, Paul C. Lobben, Jacob M. Janey, J. Eugenio de Diego, Ling Li, Iulia I. Strambeanu, Susana García-Cerrada, Javier Magano, Emma McInturff, Steven M. Mennen, Jack Twilton, David W. C. MacMillan, Fangfang Liu, Jesús Castañón, Matthew A. Zajac, Pablo Garcia-Losada, Sebastien Monfette, Mario Barberis, Alan H. Cherney, Jason M. Stevens, Barbara J. Sitter, Danielle M. Schultz, Ronald J. Post, Simon Berritt, C. Liana Allen, David C. Leitch
Publikováno v:
Organic Process Research & Development. 23:1213-1242
High-throughput experimentation (HTE) has revolutionized the pharmaceutical industry, most notably allowing for rapid screening of compound libraries against therapeutic targets. The past decade ha...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d057d4265eaefcd550f067f2a336489
https://doi.org/10.1021/acs.oprd.9b00140
https://doi.org/10.1021/acs.oprd.9b00140
Autor:
Javier Magano, Nathan D. Ide, David R. Bill, Marie O’Brien, Kyle R. Leeman, Joseph Keane, Mark T. Maloney, Joanne Tuohy, Adrian M. Daly, John Draper, Karen Sutherland, Mark Olivier, Brian P. Jones, Ke Wang, Denis Lynch, Andrew S. Palm
Publikováno v:
Organic Process Research & Development. 20:1203-1216
A three-step commercial manufacturing route has been developed for palbociclib, a highly selective, reversible inhibitor of CDK 4/6. The second step, which utilizes a Heck coupling to install the enol ether side chain, is described. A highly regiosel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2972666266493b594880af5ff733663f
https://doi.org/10.1021/acs.oprd.6b00069
https://doi.org/10.1021/acs.oprd.6b00069
Publikováno v:
Organic Process Research & Development. 20:140-177
This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d4284c9a5a45558a1c6ba5957990bb
https://doi.org/10.1021/op500305s
https://doi.org/10.1021/op500305s
Autor:
Javier Magano, Sebastien Monfette
Publikováno v:
ACS Catalysis. 5:3120-3123
The synthesis of NiCl(o-tolyl)(TMEDA) (3; TMEDA = tetramethylethylenediamine) and its application in coupling reactions is described. In combination with a suitable ligand, precatalyst 3 was applied to a wide range of transformations, such as Suzuki,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f84c681e70efd31836ff94694593942
https://doi.org/10.1021/acscatal.5b00498
https://doi.org/10.1021/acscatal.5b00498