Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Javier M, Di Noia"'
Autor:
Yue Liang, HanChen Wang, Noé Seija, Yun Hsiao Lin, Lin Tze Tung, Javier M. Di Noia, David Langlais, Anastasia Nijnik
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionBAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, through its direct catalytic activity on the repressive epigenetic mark histone H2AK119ub, as w
Externí odkaz:
https://doaj.org/article/2d7114a19c9f4754966093185d4ffaf5
Autor:
Félix Lombard-Vadnais, Geneviève Chabot-Roy, Astrid Zahn, Sahily Rodriguez Torres, Javier M. Di Noia, Heather J. Melichar, Sylvie Lesage
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105852- (2023)
Summary: Elimination of self-reactive T cells in the thymus is critical to establish T-cell tolerance. A growing body of evidence suggests a role for thymic B cells in the elimination of self-reactive thymocytes. To specifically address the role of t
Externí odkaz:
https://doaj.org/article/9b81a4e25aaf4411bb07d99e56fa8083
Autor:
Ludivine C. Litzler, Astrid Zahn, Alexandre P. Meli, Steven Hébert, Anne-Marie Patenaude, Stephen P. Methot, Adrien Sprumont, Thérence Bois, Daisuke Kitamura, Santiago Costantino, Irah L. King, Claudia L. Kleinman, Stéphane Richard, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Protective antibody responses depend critically on proper B cell development and differentiation at multiple stages. Here the authors show that a protein arginine methyltransferase, Prmt5 uses multiples pathways to prevent death of immature B cells,
Externí odkaz:
https://doaj.org/article/33da862d42ce48bf82823c6742c63b37
Autor:
Yun Hsiao Lin, Yue Liang, HanChen Wang, Lin Tze Tung, Michael Förster, Poorani Ganesh Subramani, Javier M. Di Noia, Simon Clare, David Langlais, Anastasia Nijnik
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important tumor suppressor in hu
Externí odkaz:
https://doaj.org/article/4076c37e029f441b87659d41ea81123b
Autor:
Stephen P. Methot, Ludivine C. Litzler, Poorani Ganesh Subramani, Anil K. Eranki, Heather Fifield, Anne-Marie Patenaude, Julian C. Gilmore, Gabriel E. Santiago, Halil Bagci, Jean-François Côté, Mani Larijani, Ramiro E. Verdun, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcri
Externí odkaz:
https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
Autor:
Virginia C. Rodríguez-Cortez, Paloma Martínez-Redondo, Francesc Català-Moll, Javier Rodríguez-Ubreva, Antonio Garcia-Gomez, Ganesh Poorani-Subramani, Laura Ciudad, Henar Hernando, Arantxa Pérez-García, Carlos Company, José M. Urquiza, Almudena R. Ramiro, Javier M. Di Noia, Alejandro Vaquero, Esteban Ballestar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Activation-induced cytidine deaminase (AID) triggers antibody diversification in B cells by catalysing deamination and subsequently mutating immunoglobulin (Ig) genes. Association of AID with RNA Pol II and occurrence of epigenetic changes d
Externí odkaz:
https://doaj.org/article/9cd2b9c633a74c8184f98b09354dec72
Autor:
Jessica A. Stewart, Javier M. Di Noia, Amy Hin Yan Tong, Diana Nakib, Maribel Berru, Alberto Martin, Katherine Chan, Noé Seija Desivo, Gholam Ali Kardar, James R. Carlyle, Daniel Durocher, Rukshana Mohamad-Ramshan, Yuqing Feng, Jason Moffat, Madusha L. W. Perera, Rossanna C. Pezo, Alejandro Álvarez-Quilón, Philip Barbulescu, Ashok S. Bhagwat, Gavin Li, Conglei Li
Publikováno v:
Nature
Activation-induced cytidine deaminase (AID) catalyses the deamination of deoxycytidines to deoxyuracils within immunoglobulin genes to induce somatic hypermutation and class-switch recombination1,2. AID-generated deoxyuracils are recognized and proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9900ef9c698a316ab01d156a02d6c7
https://doi.org/10.1038/s41586-021-04144-4
https://doi.org/10.1038/s41586-021-04144-4
Autor:
Shin-ichi Tsukumo, Poorani Ganesh Subramani, Noé Seija, Mizuho Tabata, Yoichi Maekawa, Yuya Mori, Chieko Ishifune, Yasushi Itoh, Mineto Ota, Keishi Fujio, Javier M. Di Noia, Koji Yasutomo
Publikováno v:
Science Advances. 8
Immunoglobulin class switch recombination (CSR) plays critical roles in controlling infections and inflammatory tissue injuries. Here, we show that AFF3 , a candidate gene for both rheumatoid arthritis and type 1 diabetes, is a molecular facilitator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4fe8f4919305a53fff5fc84458a9f3
https://doi.org/10.1126/sciadv.abq0008
https://doi.org/10.1126/sciadv.abq0008
Autor:
Santiago Bertotti, Ian Fleming, María de los Milagros Cámara, Camila Centeno Cameán, Santiago J. Carmona, Fernán Agüero, Virginia Balouz, Astrid Zahn, Javier M. Di Noia, Juan D. Alfonzo, Carlos A. Buscaglia
Publikováno v:
The Biochemical journal. 479(4)
Adenosine-to-inosine conversion at position 34 (A34-to-I) of certain tRNAs is essential for expanding their decoding capacity. This reaction is catalyzed by the adenosine deaminase acting on tRNA (ADAT) complex, which in Eukarya is formed by two subu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc66a682baa0ba549a1bfe9a38aa6ecc
https://pubmed.ncbi.nlm.nih.gov/35136964
https://pubmed.ncbi.nlm.nih.gov/35136964
Autor:
Marcelo A. Navarrete, Therence Bois, Victoria Remedi, Gabriel Fernández-Graña, Florencia Palacios, Natalia Sotelo, Stephen P. Methot, Pablo Oppezzo, Xiao-Jie Yan, Martina Crispo, Pablo Elías Morande, Nicholas Chiorazzi, Noé Seija, Javier M. Di Noia, Julieta Sepulveda, Alejandro Buschiazzo, Cecilia Abreu, Kanti R. Rai, María Elena Márquez, Natalia Rego
Publikováno v:
Blood
Blood, American Society of Hematology, 2021, ⟨10.1182/blood.2020008654⟩
Blood, American Society of Hematology, 2021, ⟨10.1182/blood.2020008654⟩
International audience; Most cancers become more dangerous by the outgrowth of malignant subclones with additional DNA mutations that favor proliferation or survival. Using chronic lymphocytic leukemia (CLL), a disease exemplary of this process, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b968efabea27f8c61fc4f1f7fb3cd8ed
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246646
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246646
