Functional Impact and Regulation of Alternative Splicing in Mouse Heart Development and Disease

Autor: Carlos Martí-Gómez, Javier Larrasa-Alonso, Marina López-Olañeta, María Villalba-Orero, Pablo García-Pavía, Fátima Sánchez-Cabo, Enrique Lara-Pezzi

Publikováno v: Journal of cardiovascular translational research. 15(6)

Alternative splicing (AS) plays a major role in the generation of transcript diversity. In the heart, roles have been described for some AS variants, but the global impact and regulation of AS patterns are poorly understood. Here, we studied the AS p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7d56ac57e68562ed1efd953aa2b259
https://pubmed.ncbi.nlm.nih.gov/35355220

SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis

Autor: Samara Martín-Alonso, Ignacio Palmero, Cristina De Lope, Ander Matheu, Javier Larrasa-Alonso, Jaione Auzmendi-Iriarte, Carmen Escudero, Irene López-Antona, Isabel Mulet

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname

Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results show that SIX1 also acts as a repressor of cell senescence, an antiproliferative response with a key role in tumor suppression, among other phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d3959d31c01d40be759d8a054db991
http://link.springer.com/article/10.1038/s41598-018-38176-0

Severe cardiac dysfunction and death caused by arrhythmogenic right ventricular cardiomyopathy type 5 are improved by Inhibition of glycogen synthase kinase-3β

Autor: Maria Victoria Gómez-Gaviro, Marina López-Olañeta, Fernando Martínez, Javier Larrasa-Alonso, Jesús Vázquez, Elena Bonzón-Kulichenko, Carlos Martí-Gómez, Paula Ortiz-Sánchez, Pablo García-Pavía, Demetrio J. Santiago, María Villalba-Orero, Laura Padron-Barthe, Jesús M. Gómez-Salinero, Marta Román, Fernando Domínguez, Enrique Lara-Pezzi, Silvia G. Priori, Belén Prados, Giovanna Giovinazzo

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria
DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Circulation

Supplemental Digital Content is available in the text.
Background: Arrhythmogenic cardiomyopathy/arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disease characterized by fibrofatty replacement of the myocardium, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070ed81e36bf586cc0a9887ace4bee53
https://hdl.handle.net/10486/690788

P5710Usefulness of preventive heart failure treatment in mice with arrhythmogenic cardiomyopathy type 5

Autor: Enrique Lara-Pezzi, F. Dominguez Rodriguez, Pablo García-Pavía, María Villalba-Orero, Marina López-Olañeta, C Marti Gomez-Aldaravi, Paula Ortiz-Sánchez, E Bello, Laura Padron-Barthe, Javier Larrasa-Alonso

Publikováno v: European Heart Journal. 39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23fe934f8cd164e93e316e936ecab159
https://doi.org/10.1093/eurheartj/ehy566.p5710

The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation

Autor: Paula Ortiz-Sánchez, Pablo García-Pavía, Leanne E. Felkin, Giovanna Giovinazo, Balaji Sundararaman, Inmaculada Navarro-Lérida, Alberto Gatto, Javier Larrasa-Alonso, Marina López-Olañeta, Gene W. Yeo, Paul J.R. Barton, Miguel A. del Pozo, Enrique Lara-Pezzi, Jesús M. Gómez-Salinero

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)

Embryonic stem cells (ESC) have the potential to generate all the cell lineages that form the body. However, the molecular mechanisms underlying ESC differentiation and especially the role of alternative splicing in this process remain poorly underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a929469b3e60d2e03d70ea366e9e2c4
https://pubmed.ncbi.nlm.nih.gov/27746127