Výsledky vyhledávání - "Javier I J, Orozco"

Akademický článek

3-D chromatin conformation, accessibility, and gene expression profiling of triple-negative breast cancer

Autor: Pere Llinàs-Arias, Miquel Ensenyat-Méndez, Javier I. J. Orozco, Sandra Íñiguez-Muñoz, Betsy Valdez, Chuan Wang, Anja Mezger, Eunkyoung Choi, Yan Zhou Tran, Liqun Yao, Franziska Bonath, Remi-André Olsen, Mattias Ormestad, Manel Esteller, Mathieu Lupien, Diego M. Marzese

Publikováno v: BMC Genomic Data, Vol 24, Iss 1, Pp 1-7 (2023)

Abstract Objectives Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Unlike other breast cancer subtypes, the scarcity of specific therapies and greater frequencies of distant metastase

Externí odkaz: https://doaj.org/article/ae6de6960e06403498b0edcc6089e71b

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Akademický článek

Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors

Publikováno v: Molecular Cancer, Vol 22, Iss 1, Pp 1-14 (2023)

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (M

Externí odkaz: https://doaj.org/article/b71cb755354f404e9aa916bdd4c51c9e

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Akademický článek

Biological effects of intraoperative radiation therapy: histopathological changes and immunomodulation in breast cancer patients

Autor: Javier I. J. Orozco, Betsy J. Valdez, Chikako Matsuba, Michael P. Simanonok, Miquel Ensenyat-Mendez, Judi Anne B. Ramiscal, Matthew P. Salomon, Yuki Takasumi, Janie G. Grumley

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionIntraoperative radiation therapy (IORT) delivers a single accelerated radiation dose to the breast tumor bed during breast-conserving surgery (BCS). The synergistic biologic effects of simultaneous surgery and radiation remain unclear. Th

Externí odkaz: https://doaj.org/article/0895d090b30b432796e47f6de6318bdb

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Akademický článek

Construction and validation of a gene expression classifier to predict immunotherapy response in primary triple-negative breast cancer

Autor: Miquel Ensenyat-Mendez, Javier I. J. Orozco, Pere Llinàs-Arias, Sandra Íñiguez-Muñoz, Jennifer L. Baker, Matthew P. Salomon, Mercè Martí, Maggie L. DiNome, Javier Cortés, Diego M. Marzese

Publikováno v: Communications Medicine, Vol 3, Iss 1, Pp 1-8 (2023)

Abstract Background Immune checkpoint inhibitors (ICI) improve clinical outcomes in triple-negative breast cancer (TNBC) patients. However, a subset of patients does not respond to treatment. Biomarkers that show ICI predictive potential in other sol

Externí odkaz: https://doaj.org/article/1f2057e671df4541b19b7339086d3e98

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Akademický článek

Current Triple-Negative Breast Cancer Subtypes: Dissecting the Most Aggressive Form of Breast Cancer

Autor: Miquel Ensenyat-Mendez, Pere Llinàs-Arias, Javier I. J. Orozco, Sandra Íñiguez-Muñoz, Matthew P. Salomon, Borja Sesé, Maggie L. DiNome, Diego M. Marzese

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Triple-negative breast cancer (TNBC) is a highly heterogeneous disease defined by the absence of estrogen receptor (ER) and progesterone receptor (PR) expression, and human epidermal growth factor receptor 2 (HER2) overexpression that lacks targeted

Externí odkaz: https://doaj.org/article/02e9a0b4b26a4ea69a1f946dbd6bca0f

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Akademický článek

Epigenetic profiling for the molecular classification of metastatic brain tumors

Autor: Javier I. J. Orozco, Theo A. Knijnenburg, Ayla O. Manughian-Peter, Matthew P. Salomon, Garni Barkhoudarian, John R. Jalas, James S. Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E. Buckland, John F. Thompson, Georgina V. Long, Charles S. Cobbs, Ilya Shmulevich, Daniel F. Kelly, Richard A. Scolyer, Dave S. B. Hoon, Diego M. Marzese

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of meta

Externí odkaz: https://doaj.org/article/48d7f470aacb41c6b7ae96cfd0196169

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Establishing Novel Molecular Subtypes of Appendiceal Cancer

Autor: Mary Garland-Kledzik, Javier I. J. Orozco, Trevan D Fischer, Juan A. Santamaria-Barria, Alessio Pigazzi, Diego M. Marzese, Miquel Ensenyat-Mendez, Anthony J Scholer, Adam Khader

Publikováno v: Annals of Surgical Oncology. 29:2118-2125

PURPOSE Appendiceal cancer is a rare disease process with complex treatment strategies. The objective of this study was to identify mutation-based genetic subtypes that may differ from the current histological classification, compare the genetic make

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fea6de5055752ac26f14a570e5eb9ade
https://doi.org/10.1245/s10434-021-10945-8

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