Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Javier Guenaga"'
Autor:
Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This c
Externí odkaz:
https://doaj.org/article/37d2ab50b881474f81175ff5bf88cc4e
Autor:
Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D. Doyle, Christopher A. Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B. Ward, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
An effective HIV vaccine likely requires the elicitation of neutralizing antibodies (NAbs) against multiple HIV-1 clades. The recently developed cleavage-independent native flexibly linked (NFL) envelope (Env) trimers exhibit well-ordered conformatio
Externí odkaz:
https://doaj.org/article/426af3d593f04edcb1ecad43361ff2ec
Autor:
Liwei Cao, Matthias Pauthner, Raiees Andrabi, Kimmo Rantalainen, Zachary Berndsen, Jolene K. Diedrich, Sergey Menis, Devin Sok, Raiza Bastidas, Sung-Kyu Robin Park, Claire M. Delahunty, Lin He, Javier Guenaga, Richard T. Wyatt, William R. Schief, Andrew B. Ward, John R. Yates, Dennis R. Burton, James C. Paulson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound
Externí odkaz:
https://doaj.org/article/4f20b420b7274e21b3fd2be2a1aa131b
Autor:
K. Rachael Parks, Anna J. MacCamy, Josephine Trichka, Matthew Gray, Connor Weidle, Andrew J. Borst, Arineh Khechaduri, Brittany Takushi, Parul Agrawal, Javier Guenaga, Richard T. Wyatt, Rhea Coler, Michael Seaman, Celia LaBranche, David C. Montefiori, David Veesler, Marie Pancera, Andrew McGuire, Leonidas Stamatatos
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3060-3072.e7 (2019)
Summary: Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1-2∗02 antibody heavy chains paired with rare light chains expressing 5-amino acid-long CDRL3s. They have been isolated from infe
Externí odkaz:
https://doaj.org/article/186a0f36c95d41e39e24afbc11ee4f79
Autor:
James J. Steinhardt, Javier Guenaga, Hannah L. Turner, Krisha McKee, Mark K. Louder, Sijy O’Dell, Chi-I Chiang, Lin Lei, Andrey Galkin, Alexander K. Andrianov, Nicole A. Doria-Rose, Robert T. Bailer, Andrew B. Ward, John R. Mascola, Yuxing Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Broadly neutralizing antibodies targeting HIV Env could potentially be utilized as therapeutics. Here, Steinhardt et al. engineer a trispecific antibody with specificity for the receptor-binding site, a conserved Env glycan patch and the Env membrane
Externí odkaz:
https://doaj.org/article/03eaed1d2e664ef483d4e8852e3946e7
Autor:
Liwei Cao, Jolene K. Diedrich, Daniel W. Kulp, Matthias Pauthner, Lin He, Sung-Kyu Robin Park, Devin Sok, Ching Yao Su, Claire M. Delahunty, Sergey Menis, Raiees Andrabi, Javier Guenaga, Erik Georgeson, Michael Kubitz, Yumiko Adachi, Dennis R. Burton, William R. Schief, John R. Yates III, James C. Paulson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The analysis of site-specific glycosylation of HIV Envelope glycoprotein (Env) is challenging as it contains 25–30 glycosylation sites with multiple glycan forms at each site. Here the authors present a generally applicable mass spectrometry-based
Externí odkaz:
https://doaj.org/article/b94d469c8f5c4c89a79f2c9ed20be9ab
Autor:
Sara Landeras-Bueno, Shun-ichiro Oda, Michael J. Norris, Zhe Li Salie, Javier Guenaga, Richard T. Wyatt, Erica Ollmann Saphire
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The filoviruses are etiological agents of life-threatening hemorrhagic fever with high mortality rate and risk of potential outbreak. Among members of this family, the Ebola (EBOV), Sudan (SUDV), and Marburg (MARV) viruses are considered the
Externí odkaz:
https://doaj.org/article/e8b10b7a660545c983dc47c5094b4419
Autor:
Jidnyasa Ingale, Armando Stano, Javier Guenaga, Shailendra Kumar Sharma, David Nemazee, Michael B. Zwick, Richard T. Wyatt
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 1986-1999 (2016)
A major step toward an HIV-1 vaccine is an immunogen capable of inducing neutralizing antibodies. Envelope glycoprotein (Env) mimetics, such as the NFL and SOSIP designs, generate native-like, well-ordered trimers and elicit tier 2 homologous neutral
Externí odkaz:
https://doaj.org/article/ca6f353d4f8f4d5ebadc2e5dcbb86d2a
Autor:
Lifei Yang, Shailendra Kumar Sharma, Christopher Cottrell, Javier Guenaga, Karen Tran, Richard Wilson, Anna-Janina Behrens, Max Crispin, Natalia de Val, Richard T. Wyatt
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Soluble HIV-1 envelope glycoprotein (Env) trimers are under active investigation as vaccine candidates in relevant pre-clinical models. Like SOSIPs, the cleavage-independent native flexibly linked (NFL) trimers are faithful mimics of the Env spike. H
Externí odkaz:
https://doaj.org/article/5e98d8fda0de41c6913a468c19572d9b
Autor:
Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 539-550 (2015)
Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycopro
Externí odkaz:
https://doaj.org/article/2acc78d7717d48479da8ce020bf5668a