Zobrazeno 1 - 10 of 155 pro vyhledávání: '"Javier González-Maeso"'
1
Akademický článek
Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia
Autor: Bohan Zhu, Richard I Ainsworth, Zengmiao Wang, Zhengzhi Liu, Salvador Sierra, Chengyu Deng, Luis F Callado, J Javier Meana, Wei Wang, Chang Lu, Javier González-Maeso
Publikováno v: eLife, Vol 12 (2024)
Genome-wide association studies have revealed >270 loci associated with schizophrenia risk, yet these genetic factors do not seem to be sufficient to fully explain the molecular determinants behind this psychiatric condition. Epigenetic marks such as
Externí odkaz: https://doaj.org/article/3d93059727454ba289151c44ddd8e836
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2
Akademický článek
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes
Autor: Qiang Zhang, Sai Ma, Zhengzhi Liu, Bohan Zhu, Zirui Zhou, Gaoshan Li, J. Javier Meana, Javier González-Maeso, Chang Lu
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA methylomic studies offer unprecedented resolution for detect
Externí odkaz: https://doaj.org/article/996b421228474e3b866bd4eb054878ca
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3
Akademický článek
Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice
Autor: Jennifer T. Wolstenholme, Justin M. Saunders, Maren Smith, Jason D. Kang, Phillip B. Hylemon, Javier González-Maeso, Andrew Fagan, Derrick Zhao, Masoumeh Sikaroodi, Jeremy Herzog, Amirhossein Shamsaddini, Marcela Peña-Rodríguez, Lianyong Su, Yun-Ling Tai, Jing Zheng, Po-Cheng Cheng, R. Balfour Sartor, Patrick M. Gillevet, Huiping Zhou, Jasmohan S. Bajaj
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gut microbiota composition is altered in patients with alcohol use disorder, and fecal microbiota transplant reduced alcohol craving in patients with alcohol use disorder and liver cirrhosis in a phase 1 clinical trial. Here the authors used stool sa
Externí odkaz: https://doaj.org/article/71cd530afe02445e92a5c780310d4264
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4
Akademický článek
Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice
Autor: Mario de la Fuente Revenga, Bohan Zhu, Christopher A. Guevara, Lynette B. Naler, Justin M. Saunders, Zirui Zhou, Rudy Toneatti, Salvador Sierra, Jennifer T. Wolstenholme, Patrick M. Beardsley, George W. Huntley, Chang Lu, Javier González-Maeso
Publikováno v: Cell Reports, Vol 37, Iss 3, Pp 109836- (2021)
Summary: Clinical evidence suggests that rapid and sustained antidepressant action can be attained with a single exposure to psychedelics. However, the biological substrates and key mediators of psychedelics’ enduring action remain unknown. Here, w
Externí odkaz: https://doaj.org/article/43705a14b3dc480c8aba3ee0cb75a2bd
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6
Akademický článek
Elucidation of molecular kinetic schemes from macroscopic traces using system identification.
Autor: Miguel Fribourg, Diomedes E Logothetis, Javier González-Maeso, Stuart C Sealfon, Belén Galocha-Iragüen, Fernando Las-Heras Andrés, Vladimir Brezina
Publikováno v: PLoS Computational Biology, Vol 13, Iss 2, p e1005376 (2017)
Overall cellular responses to biologically-relevant stimuli are mediated by networks of simpler lower-level processes. Although information about some of these processes can now be obtained by visualizing and recording events at the molecular level,
Externí odkaz: https://doaj.org/article/0dbc498a0781429285cc7ee510a2e705
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