Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Javier Garcia-Castro"'
Autor:
Marion Rabé, Lucie Fonteneau, Lisa Oliver, Alvaro Morales-Molina, Camille Jubelin, Javier Garcia-Castro, Dominique Heymann, Catherine Gratas, François M. Vallette
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
We have observed a drug-tolerant/persister state in a human glioblastoma (GBM) cell line after exposure to temozolomide, the standard-of-care chemotherapeutic agent for GBM. We used a multicolor lentiviral genetic barcode labeling to follow cell popu
Externí odkaz:
https://doaj.org/article/af10a72ecb07478da8fef7c1d545335e
Autor:
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz, Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela, Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)
Abstract Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and compr
Externí odkaz:
https://doaj.org/article/32421af97ff64f339c73c8bfd6f57409
Publikováno v:
Cancers, Vol 13, Iss 9, p 2003 (2021)
Osteosarcoma (OS) is a highly aggressive tumor characterized by malignant cells producing pathologic bone; the disease presents a natural tendency to metastasize. Genetic studies indicate that the OS genome is extremely complex, presenting signs of m
Externí odkaz:
https://doaj.org/article/4156dabd422d492181994b195a06b32a
Autor:
Ana Almazán-Moga, Patricia Zarzosa, Isaac Vidal, Carla Molist, Irina Giralt, Natalia Navarro, Aroa Soriano, Miguel F. Segura, Arantza Alfranca, Javier Garcia-Castro, José Sánchez de Toledo, Josep Roma, Soledad Gallego
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and can be divided into two main subtypes: embryonal (eRMS) and alveolar (aRMS). Among the cellular heterogeneity of tumors, the existence of a small fraction of cells
Externí odkaz:
https://doaj.org/article/d6b81fbcd77a4ae7bc53ac0055a40e73
Autor:
Ander Abarrategi, Juan Tornin, Lucia Martinez-Cruzado, Ashley Hamilton, Enrique Martinez-Campos, Juan P. Rodrigo, M. Victoria González, Nicola Baldini, Javier Garcia-Castro, Rene Rodriguez
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone. Although standard chemotherapy has significantly improved long-term survival over the past few decades, the outcome for those patients with metastatic or recurren
Externí odkaz:
https://doaj.org/article/7ba0c1c6769c42b98a125a0de444787f
Autor:
Vincenzo Calvanese, Angelica Horrillo, Abdelkrim Hmadcha, Beatriz Suarez-Alvarez, Agustín F Fernandez, Ester Lara, Sara Casado, Pablo Menendez, Clara Bueno, Javier Garcia-Castro, Ruth Rubio, Pablo Lapunzina, Miguel Alaminos, Lodovica Borghese, Stefanie Terstegge, Neil J Harrison, Harry D Moore, Oliver Brüstle, Carlos Lopez-Larrea, Peter W Andrews, Bernat Soria, Manel Esteller, Mario F Fraga
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3294 (2008)
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cance
Externí odkaz:
https://doaj.org/article/5c9e288ab70f4485a515a9c0508920fa
Autor:
Daniel Rubio, Silvia Garcia, Maria F Paz, Teresa De la Cueva, Luis A Lopez-Fernandez, Alison C Lloyd, Javier Garcia-Castro, Antonio Bernad
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1398 (2008)
BACKGROUND: We previously reported the in vitro spontaneous transformation of human mesenchymal stem cells (MSC) generating a population with tumorigenic potential, that we termed transformed mesenchymal cells (TMC). METHODOLOGY/PRINCIPAL FINDINGS: H
Externí odkaz:
https://doaj.org/article/92f5a95393224725b5c183c62b9febfb
Autor:
Laura Hidalgo, Beatriz Somovilla-Crespo, Patricia Garcia-Rodriguez, Alvaro Morales-Molina, Miguel Angel Rodriguez-Milla, Javier Garcia-Castro
Immunotherapy with chimeric antigen receptor T (CAR T) cells has changed the treatment of hematological malignances, but they are still a challenge for solid tumors, including pediatric sarcomas. Here, we report a switchable CAR T cell strategy based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b70ca9c71dde46e3a2f04607de8e368
https://hdl.handle.net/20.500.12105/16059
https://hdl.handle.net/20.500.12105/16059
Autor:
Antonio Bernad, Alison C. Lloyd, Juan C. Cigudosa, Ricardo de la Fuente, María C. Martín, Javier Garcia-Castro, Daniel Rubio
Human adult stem cells are being evaluated widely for various therapeutic approaches. Several recent clinical trials have reported their safety, showing them to be highly resistant to transformation. The clear similarities between stem cell and cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1ccc632457f418ad99cadc9036cd0c
https://doi.org/10.1158/0008-5472.c.6494265
https://doi.org/10.1158/0008-5472.c.6494265
Autor:
Antonio Bernad, Alison C. Lloyd, Juan C. Cigudosa, Ricardo de la Fuente, María C. Martín, Javier Garcia-Castro, Daniel Rubio
Supplementary Figure 1 from Spontaneous Human Adult Stem Cell Transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ee099ff3739c30565363e2db8b65a7
https://doi.org/10.1158/0008-5472.22364589.v1
https://doi.org/10.1158/0008-5472.22364589.v1