Výsledky vyhledávání - "Javier G Magadán"

Akademický článek

Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs.

Autor: Ivan Kosik, William L Ince, Lauren E Gentles, Andrew J Oler, Martina Kosikova, Matthew Angel, Javier G Magadán, Hang Xie, Christopher B Brooke, Jonathan W Yewdell

Publikováno v: PLoS Pathogens, Vol 14, Iss 1, p e1006796 (2018)

Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. Understanding viral mechanisms that enable antigenic evolution is critical for designing durable vaccines a

Externí odkaz: https://doaj.org/article/a8d6e151814b4d49b5ff844bb40bacbc

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Akademický článek

Biogenesis of influenza a virus hemagglutinin cross-protective stem epitopes.

Autor: Javier G Magadán, Meghan O Altman, William L Ince, Heather D Hickman, James Stevens, Aaron Chevalier, David Baker, Patrick C Wilson, Rafi Ahmed, Jack R Bennink, Jonathan W Yewdell

Publikováno v: PLoS Pathogens, Vol 10, Iss 6, p e1004204 (2014)

Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza virus strains, HA stem-reactive antibodies

Externí odkaz: https://doaj.org/article/74024ffa48a944a1a6108bc9315387d3

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Akademický článek

Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

Autor: Javier G Magadán, F Javier Pérez-Victoria, Rachid Sougrat, Yihong Ye, Klaus Strebel, Juan S Bonifacino

Publikováno v: PLoS Pathogens, Vol 6, Iss 4, p e1000869 (2010)

A key function of the Vpu protein of HIV-1 is the targeting of newly-synthesized CD4 for proteasomal degradation. This function has been proposed to occur by a mechanism that is fundamentally distinct from the cellular ER-associated degradation (ERAD

Externí odkaz: https://doaj.org/article/b4af1b28336d4ae68de1fc8c66b7767a

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Correction: Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

Autor: Lauren E. Gentles, Martina Kosikova, Javier G. Magadán, Jonathan W. Yewdell, Andrew J. Oler, Matthew Angel, Ivan Kosik, Hang Xie, Christopher B. Brooke, William L. Ince

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 14, Iss 6, p e1007141 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c57ada486b9c064b37f4d30b98bf6f2
https://pubmed.ncbi.nlm.nih.gov/29346435

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Influenza A Virus Negative Strand RNA is Translated for CD8+ T Cell Immunosurveillance

Autor: Daniel McManus, Barbara F. Ngudiankama, Jacqueline W. Mays, Heather D. Hickman, John P. Shannon, Javier G. Magadán, Kazuyo Takeda, Jonathan W. Yewdell, Ivan Kosik, James S. Gibbs, Jiajie Wei, Glennys V. Reynoso, Suman R. Das

Probing the limits of CD8+ T cell immunosurveillance, we inserted the SIINFEKL peptide into influenza A virus (IAV)-negative strand gene segments. Although IAV genomic RNA is considered noncoding, there is a conserved, relatively long open reading fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a94b9cdb0574c4d8c1bf590e66c2b70
https://doi.org/10.1101/261966

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Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

Autor: Christopher B. Brooke, Javier G. Magadán, Matthew Angel, Andrew J. Oler, Ivan Kosik, Jonathan W. Yewdell, Martina Kosikova, Lauren E. Gentles, William L. Ince, Hang Xie

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Pathogens, Vol 14, Iss 1, p e1006796 (2018)
PLoS Pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17184d89f705e8496a2c19482cf55cdd
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006796

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Radioactive Pulse-Chase Analysis and Immunoprecipitation

Autor: Javier G. Magadán

Publikováno v: Bio-protocol. 4(8)

Labeling of newly-synthesized polypeptides with radioactive amino acids followed by immunoprecipitation allows quantitative analysis of the fate of a given protein in a time-dependent manner. This biochemical approach is usually used to study a varie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a03197d257641d705a0c0669575fd7
https://pubmed.ncbi.nlm.nih.gov/28480315

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Structural Basis for the Recognition of Tyrosine-based Sorting Signals by the μ3A Subunit of the AP-3 Adaptor Complex

Autor: Patricia V. Burgos, Gonzalo A. Mardones, Yimo Lin, Juan S. Bonifacino, Daniel P. Kloer, Javier G. Magadán, James H. Hurley

Publikováno v: JOURNAL OF BIOLOGICAL CHEMISTRY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Tyrosine-based signals fitting the YXXO motif mediate sorting of transmembrane proteins to endosomes, lysosomes, the basolateral plasma membrane of polarized epithelial cells, and the somatodendritic domain of neurons through interactions with the ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2ddf99a8cde63488669d8a039bbb37
https://doi.org/10.1074/jbc.m113.450775

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Monitoring cotranslational protein folding in mammalian cells at codon resolution

Autor: Botao Liu, Javier G. Magadán, Yan Han, Shu-Bing Qian, Jack R. Bennink, Jonathan W. Yewdell, Alexandre David

Publikováno v: Proceedings of the National Academy of Sciences. 109:12467-12472

How the ribosome-bound nascent chain folds to assume its functional tertiary structure remains a central puzzle in biology. In contrast to refolding of a denatured protein, cotranslational folding is complicated by the vectorial nature of nascent cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09e66d383ae7e2ffd9078c03659f220
https://doi.org/10.1073/pnas.1208138109

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