Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Javier Frias Aldeguer"'
Autor:
Erik J. Vrij, Yvonne S. Scholte op Reimer, Laury Roa Fuentes, Isabel Misteli Guerreiro, Viktoria Holzmann, Javier Frias Aldeguer, Giovanni Sestini, Bon-Kyoung Koo, Jop Kind, Clemens A. van Blitterswijk, Nicolas C. Rivron
Publikováno v:
Development (Cambridge), 149(20). Company of Biologists Ltd
Development, 149(20):dev192310. Company of Biologists Ltd
Development
Development, 149(20):dev192310. Company of Biologists Ltd
Development
Embryogenesis is supported by dynamic loops of cellular interactions. Here, we create a partial mouse embryo model to elucidate the principles of epiblast (Epi) and extra-embryonic endoderm co-development (XEn). We trigger naive mouse embryonic stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b9bbcf3f5973f773d129fc7a0148b3
https://pure.knaw.nl/portal/en/publications/68d1c94d-eaa5-4672-8b61-3acbd4bcba2d
https://pure.knaw.nl/portal/en/publications/68d1c94d-eaa5-4672-8b61-3acbd4bcba2d
Autor:
Jinwoo Seong, Javier Frias-Aldeguer, Viktoria Holzmann, Harunobu Kagawa, Giovanni Sestini, Heidar Heidari Khoei, Yvonne Scholte Op Reimer, Maarten Kip, Saurabh J. Pradhan, Lucas Verwegen, Judith Vivié, Linfeng Li, Anna Alemany, Jeroen Korving, Frank Darmis, Alexander van Oudenaarden, Derk ten Berge, Niels Geijsen, Nicolas C. Rivron
Publikováno v:
Cell Stem Cell, 29(7), 1102-1118.e8. CELL PRESS
Cell stem cell, 29(7), 1102-1118.e8. Cell Press
Cell Stem Cell, 29(7), 1102-1118.e8. Cell Press
Cell Stem Cell
Cell stem cell, 29(7), 1102-1118.e8. Cell Press
Cell Stem Cell, 29(7), 1102-1118.e8. Cell Press
Cell Stem Cell
The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development. Here, we defined an optimal set of molecules secret
Autor:
Nicolas C. Rivron, Ábel Vértesy, Javier Frias-Aldeguer, Niels Geijsen, Zeliha Sahin, Alexander van Oudenaarden
During germ cell development, cells undergo a drastic switch from mitosis to meiosis to form haploid germ cells. Sequencing and computational technologies now allow studying development at the single-cell level. Here we developed a multiplexed trajec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3838cefcec755dfedd13598a1dc3c3fc
https://doi.org/10.1101/665372
https://doi.org/10.1101/665372
Autor:
Jeroen Korving, Judith Vivié, Clemens van Blitterswijk, Linfeng Li, Nicolas C. Rivron, Alexander van Oudenaarden, Niels Geijsen, Maarten Kip, Javier Frias-Aldeguer, Frank Darmis, Anna Alemany
Early mammalian embryos form a blastocyst, a structure comprising embryonic cells surrounded by a trophoblast cyst able to implant into the mother’s uterus. Following subtle symmetry-breaking events (Zhang and Hiiragi, 2018), an axis forms in the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755254a8aa6606bc92dc922cdd573692
https://doi.org/10.1101/510362
https://doi.org/10.1101/510362
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Autor:
Kay Wiebrands, Daniel E. Stange, Marc van de Wetering, Teresa G Krieger, Hans Clevers, Benjamin D. Simons, Johan H. van Es, Javier Frias-Aldeguer, Onur Basak, Alexander van Oudenaarden, Mauro J. Muraro, Nicolas C. Rivron
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 115(4), E610-E619. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 115(4), E610
Proceedings of the National Academy of Sciences of the United States of America, 115(4), E610
The adult mouse subependymal zone provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential, and fate behavior of NSCs remain poorly defined. Here we propose a model in which the fate of active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbfd29d7e4a1652b0dada0bb56a090f
https://pure.knaw.nl/portal/en/publications/075eaeb5-63f1-4473-9535-aca6f7934bd2
https://pure.knaw.nl/portal/en/publications/075eaeb5-63f1-4473-9535-aca6f7934bd2
Autor:
Javier Frias-Aldeguer, Judith Vivié, Clemens van Blitterswijk, Nicolas C. Rivron, Roman Truckenmüller, Niels Geijsen, E.J. Vrij, Alexander van Oudenaarden, Jean Charles Boisset, Jeroen Korving
Publikováno v:
Nature
Nature, 557(7703), 106-111. Nature Publishing Group
Nature, 557(7703), 106. Nature Research
Nature, 557(7703), 106. Nature Publishing Group
Nature, 557(7703), 106-111. Nature Publishing Group
Nature, 557(7703), 106. Nature Research
Nature, 557(7703), 106. Nature Publishing Group
The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic tissues, including the placenta. It consists of a spherical thin-walled layer, known as the trophectoderm, that surrounds a fluid-filled cavity sheltering the embryon
Publikováno v:
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 13(2)
It is now well established that human pancreatic ductal adenocarcinoma (PDAC) contains a subset of cells with self-renewal capabilities and subsequent exclusive in vivo tumorigenic capacity as assessed by limiting dilution tumorigenic transplantation
Publikováno v:
Cell Cycle; Vol 11
Cell Cycle
Cell Cycle
Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are characterized by extensive fibrosis. Importantly, in PDAC, this results in poor vascularization and impaired drug delivery to the cancer cells. Therefore, the combined targeting of