Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Javier Fernández–Mateos"'
Autor:
Benjamin Werner, Jack Case, Marc J. Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D. Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian P. M. Tomlinson, Chris P. Barnes, Trevor A. Graham, Andrea Sottoriva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Quantifying somatic evolutionary processes in cancer and healthy tissue is a challenge. Here, the authors use single time point multi-region sampling of cancer and normal tissue, combined with evolutionary theory, to quantify in vivo mutation and cel
Externí odkaz:
https://doaj.org/article/1cc8e57a38b3428da9bd484790ebf103
Autor:
Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumour
Externí odkaz:
https://doaj.org/article/2a6d4d6151124d12a8c1eba89b44d361
Autor:
Gloria López-Valverde, Elena Garcia-Martin, Javier Fernández-Mateos, Fernando Cruz-González, José M. Larrosa-Povés, Vicente Polo-Llorens, Luis E. Pablo-Júlvez
Publikováno v:
Revista Mexicana de Oftalmología, Vol 91, Iss 2, Pp 56-61 (2017)
Objetivo: Determinar si el consumo de tabaco, alcohol, la presencia de hipertensión (HTA) y la diabetes son factores de riesgo (FR) para el desarrollo de cataratas. Métodos: Se realizó un estudio retrospectivo comparando 3 grupos de pacientes: 72
Externí odkaz:
https://doaj.org/article/32d7f88aff5d4fae9dd0754f52237c5c
Autor:
Gloria López Valverde, Elena Garcia Martin, José M Larrosa Povés, Vicente Polo Llorens, Javier Fernández Mateos, Luis E Pablo Júlvez, Rogelio González Sarmiento
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0171395 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0156317.].
Externí odkaz:
https://doaj.org/article/0273dfacc89144e4acbcab506a672682
Autor:
Hernán Llorente, Jose-Angel Perez-Rivera, María Perez-Nieto, Clara Cieza-Borrella, Isabel Pastor, Ignacio Novo-Veleiro, Javier Fernández-Mateos, Antonio-Javier Chamorro, Patricia Crecente-Otero, Francisco-Javier Laso, Rogelio González-Sarmiento, Miguel Marcos
Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated with short telomere length (TL). This study was conducted to examine the relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f205b3dd3e8ac7b8af2520d5cd5e3f2a
https://openaccess.sgul.ac.uk/id/eprint/114478/1/1-s2.0-S0047637422000756-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/114478/1/1-s2.0-S0047637422000756-main.pdf
Autor:
Gloria López Valverde, Elena Garcia Martin, José M Larrosa Povés, Vicente Polo Llorens, Javier Fernández Mateos, Luis E Pablo Júlvez, Rogelio González Sarmiento
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156317 (2016)
PURPOSE:To determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development. METHODS:We have performed a retrospective study over three groups of pati
Externí odkaz:
https://doaj.org/article/cca7149e96b746a9af6300c304028336
Autor:
Javier Fernández-Mateos, Andrea Sottoriva, Carlo C. Maley, Inmaculada Spiteri, Udai Banerji, Benjamin Werner, Ahmet Acar, Mark Stubbs, Luca Magnani, Sung Pil Hong, Giulio Caravagna, Adam Stewart, Nicholas A. Trahearn, Daniel Nichol, Nicola Valeri, Georgios Vlachogiannis, Rosemary Burke, George D. Cresswell, Iros Barozzi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug. These evolutionary trad
Autor:
Inma Spiteri, Andrea Sottoriva, Daniel Nichol, Maximilian Mossner, Manuel Rodriguez-Justo, Timon Heide, Luca Magnani, Javier Fernández-Mateos, Chela James, Christopher Kimberley, Bingjie Chen, Marnix Jansen, Iros Barozzi, Kate Chkhaidze, Melissa Schmidt, Daniele Ramazzotti, Claire Lynn, Luis Zapata, Miriam Mitchinson, John Bridgewater, Ann-Marie Baker, Jacob Househam, Trevor A. Graham, Giulio Caravagna, Helena Costa, Darryl Shibata, Eszter Lakatos, George D. Cresswell, Alison May Berner
Colorectal malignancies are a leading cause of cancer death. Despite large-scale genomic efforts, DNA mutations do not fully explain malignant evolution. Here we study the co-evolution of the genome and epigenome of colorectal tumours at single-clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b816f22ce1fa5e45de2836bcdc207480
https://doi.org/10.21203/rs.3.rs-797138/v1
https://doi.org/10.21203/rs.3.rs-797138/v1
Autor:
Luis Zapata, Melissa Schmidt, Maximilian Mossner, Marnix Jansen, Chris Kimberley, Miriam Mitchinson, Calum Gabbutt, Giulio Caravagna, Jacob Househam, Helena Costa, Alison May Berner, Inmaculada Spiteri, Bingjie Chen, Claire Lynn, George D. Cresswell, John Bridgewater, Manuel Rodriguez-Justo, Darryl Shibata, Timon Heide, Luca Magnani, Trevor A. Graham, Andrea Sottoriva, Daniel Nichol, Javier Fernández-Mateos, Ann-Marie Baker, Eszter Lakatos, Chela James
Cancer evolution is driven by natural selection acting upon phenotypic trait variation. However, the extent to which phenotypic variation within a tumour is a consequence of intra-tumour genetic heterogeneity remains undetermined. Here we show that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc61b0f47b8c0a0148b0e7543cf7a061
https://doi.org/10.1101/2021.07.18.451272
https://doi.org/10.1101/2021.07.18.451272
Autor:
Miriam Mitchinson, Giulio Caravagna, Luca Magnani, Chris Kimberley, Chris P. Barnes, John Bridgewater, Inmaculada Spiteri, Calum Gabbutt, Melissa Schmidt, Alison May Berner, Manuel Rodriguez-Justo, Marnix Jansen, Claire Lynn, Max Mossner, Chela James, Daniele Ramazzotti, Luis Zapata, Jacob Househam, Bingjie Chen, Alessandro Vinceti, Darryl Shibata, Helena Costa, George D. Cresswell, Ann-Marie Baker, Benjamin Werner, Timon Heide, Francesco Iorio, Eszter Lakatos, Javier Fernández-Mateos, Andrea Sottoriva, Trevor A. Graham, Daniel Nichol
Cancer genomic medicine relies on targeting driver genes. However, current catalogues of cancer drivers are mostly based on indirect measurements of mutation frequencies, positions or types, rather than their effect on clonal expansionsin vivo. Moreo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086556328d77d35edfc59a809cb8cf92
https://doi.org/10.1101/2021.07.14.451265
https://doi.org/10.1101/2021.07.14.451265