Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Javier E. Irazoqui"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In recent years, transcription factors of the Microphthalmia-TFE (MiT) family, including TFEB and TFE3 in mammals and HLH-30 in Caenorhabditis elegans, have emerged as important regulators of innate immunity and inflammation in invertebrates and vert
Externí odkaz:
https://doaj.org/article/05d2f5633e18479785c298a358d9aaef
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/3a3e8baff3494a3d8a502f836adab9fe
Autor:
Khursheed A Wani, Debanjan Goswamy, Stefan Taubert, Ramesh Ratnappan, Arjumand Ghazi, Javier E Irazoqui
Publikováno v:
eLife, Vol 10 (2021)
The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestinal bacterial infections that elicit overlapping starvation and infection responses, the regulation of which is not well understood. Direct comparison o
Externí odkaz:
https://doaj.org/article/03c71d72b3f440ee89b5c14c2ba4609d
Positive and negative regulators of innate immunity work together to maintain immune homeostasis. We previously discovered that HLH-30/TFEB is a critical transcription factor that positively regulates host defense genes upon S. aureus infection in C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48ab7e244c9c86c2ed26f889613ab03d
https://doi.org/10.1101/2022.09.12.507697
https://doi.org/10.1101/2022.09.12.507697
Publikováno v:
Frontiers in cellular and infection microbiology. 12
Publikováno v:
Autophagy
Macrophage activation in the presence of bacterial cells and molecules entails complex programs of gene expression. How such triggers elicit specific gene expression programs is incompletely understood. We previously discovered that TFEB (transcripti
Publikováno v:
Curr Opin Neurobiol
Interplay between the nervous and immune systems is critical for homeostasis, and its dysfunction underlies pathologies such as multiple sclerosis, autism, leukemia, and inflammation. The nematode Caenorhabditis elegans provides an opportunity to def
Autor:
Ramesh Ratnappan, Javier E. Irazoqui, Debanjan Goswamy, Arjumand Ghazi, Stefan Taubert, Khursheed A. Wani
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The model organism Caenorhabditis elegans mounts transcriptional defense responses against intestinal bacterial infections that elicit overlapping starvation and infection responses, the regulation of which is not well understood. Direct comparison o
Autor:
Javier E. Irazoqui, Debanjan Goswamy
Publikováno v:
Curr Opin Immunol
During intestinal infection, microbes induce ROS by various mechanisms in C. elegans. ROS can have beneficial roles, acting as antimicrobials and as signaling molecules that activate cytoprotective pathways. Failure to maintain appropriate levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503702aabc96cfd8a47fed65264afa94
https://europepmc.org/articles/PMC7925333/
https://europepmc.org/articles/PMC7925333/