Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Javier Chaparro-Riggers"'
Autor:
Changhua Ji, Bing Kuang, Bernard S Buetow, Allison Vitsky, Yuanming Xu, Tzu-Hsuan Huang, Javier Chaparro-Riggers, Eugenia Kraynov, Diane Matsumoto
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298240 (2024)
PF-07209960 is a novel bispecific fusion protein composed of an anti-PD-1 antibody and engineered IL-15 cytokine mutein with reduced binding affinity to its receptors. The pharmacokinetics (PK), pharmacodynamics (PD), and toxicity of PF-07209960 were
Externí odkaz:
https://doaj.org/article/c39ae2f51f884dbb9d5bbfa5463a5364
Autor:
Spencer Park, Edward Pascua, Kevin C. Lindquist, Christopher Kimberlin, Xiaodi Deng, Yvonne S. L. Mak, Zea Melton, Theodore O. Johnson, Regina Lin, Bijan Boldajipour, Robert T. Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J. Van Blarcom, Javier Chaparro-Riggers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.
Externí odkaz:
https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec
Autor:
Shahram Salek-Ardakani, Wenjing Yang, Sheng Ding, Shih-Hsun Chen, Jessica Stanfield, Nadia Kurd, Ryan Llewellyn, Jonathan Heyen, Carole Wang, Zea Melton, Javier Chaparro-Riggers, Pawel Dominik, Kevin Lindquist, Thomas Van Blarcom
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/1f019c3519b849a08123380e84c26521
Autor:
Shahram Salek-Ardakani, Wenjing Yang, Sheng Ding, Shih-Hsun Chen, Pawel K Dominik, Jessica Stanfield, Nadia Kurd, Ryan Llewellyn, Jonathan Heyen, Carole Wang, Zea Melton, Thomas Van Blarcom, Kevin C Lindquist, Javier Chaparro-Riggers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 10 (2021)
Externí odkaz:
https://doaj.org/article/3920fe53e43c44dd89bb0d4a1c33ff53
Autor:
S. Michael Chin, Christopher R. Kimberlin, Zygy Roe-Zurz, Pamela Zhang, Allison Xu, Sindy Liao-Chan, Debasish Sen, Andrew R. Nager, Nicole Schirle Oakdale, Colleen Brown, Feng Wang, Yuting Yang, Kevin Lindquist, Yik Andy Yeung, Shahram Salek-Ardakani, Javier Chaparro-Riggers
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The costimulatory T-cell receptor 4-1BB is an immuno-oncology target. Here the authors present the ligand bound 4-1BB receptor crystal structure in addition to the structures of 4-1BB bound with two therapeutic antibodies and verify the antibody bind
Externí odkaz:
https://doaj.org/article/11f466e447544959a4ac278b485a238c
Autor:
Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C. Lindquist, Patrick J. Doonan, Tom Van Blarcom, Yik Andy Yeung, Javier Chaparro-Riggers
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
T-cell engaging biologics is a class of novel and promising immune-oncology compounds that leverage the immune system to eradicate cancer. Here, we compared and contrasted a bispecific diabody-Fc format, which displays a relatively short antigen-bind
Externí odkaz:
https://doaj.org/article/689b1a83bc0d495ead97d93c01362efb
Autor:
Yik Andy Yeung, Davide Foletti, Xiaodi Deng, Yasmina Abdiche, Pavel Strop, Jacob Glanville, Steven Pitts, Kevin Lindquist, Purnima D. Sundar, Marina Sirota, Adela Hasa-Moreno, Amber Pham, Jody Melton Witt, Irene Ni, Jaume Pons, David Shelton, Arvind Rajpal, Javier Chaparro-Riggers
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Staphylococcus aureuscan both cause disease in humans and be present with no discernible effect. Here, the authors look in detail at the memory immune response against a protein involved in iron acquisition.
Externí odkaz:
https://doaj.org/article/2761e2c97b344bc6b55beb67dcda4616
Autor:
Pamela Zhang, Guang Huan Tu, Jie Wei, Pamela Santiago, Lance R. Larrabee, Sindy Liao-Chan, Tina Mistry, Matthew Ling-Hon Chu, Tao Sai, Kevin Lindquist, Hua Long, Javier Chaparro-Riggers, Shahram Salek-Ardakani, Yik Andy Yeung
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3117-3123.e5 (2019)
Summary: Agonistic antibodies targeting the tumor necrosis factor (TNF) superfamily of co-stimulatory receptors (TNFRSF) are progressing through various stages of clinical development for cancer treatment, but the desired and defining features of the
Externí odkaz:
https://doaj.org/article/44cb539f22be4485ababb5654bc38b0f
Autor:
Rebecca P, Chen, Kenta, Shinoda, Pragya, Rampuria, Fang, Jin, Tin, Bartholomew, Chunxia, Zhao, Fan, Yang, Javier, Chaparro-Riggers
Publikováno v:
Expert Opinion on Biological Therapy. 22:965-982
Following the approval of the T cell engaging bispecific antibody blinatumomab, immune cell retargeting with bispecific or multispecific antibodies has emerged as a promising cancer immunotherapy strategy, offering alternative mechanisms compared to
Autor:
Barbra J. Sasu, Javier Chaparro-Riggers, Thomas Van Blarcom, Tao Sai, Jonathan R. Heyen, Roman Galetto, Mathilde Dusseaux, Adit Ghosh, Zea Melton, Shanshan Lang, Dinali Wijewarnasuriya, Jonathan Villanueva, Hongxiu Ning, Yvonne S.L. Mak, Bryan Smith, Silvia K. Tacheva-Grigorova, Nguyen Tan, Surabhi Srinivasan, Siler H. Panowski
Supplementary Figure from Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cc395cc018d8b6bdfec74c65ff1896
https://doi.org/10.1158/0008-5472.22674159.v1
https://doi.org/10.1158/0008-5472.22674159.v1