Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Javier Celis-Gutierrez"'
Autor:
Kilian Ruminski, Javier Celis-Gutierrez, Nicolas Jarmuzynski, Emilie Maturin, Stephane Audebert, Marie Malissen, Luc Camoin, Guillaume Voisinne, Bernard Malissen, Romain Roncagalli
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The propagation and diversification of signals downstream of the T cell receptor (TCR) involve several adaptor proteins that control the assembly of multimolecular signaling complexes (signalosomes). The global characterization of changes in protein-
Externí odkaz:
https://doaj.org/article/5e912809456643aba8f129a48c1cf596
Autor:
Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Claude Grégoire, Youcef Ounoughene, Frédéric Fiore, Ruedi Aebersold, Romain Roncagalli, Matthias Gstaiger, Bernard Malissen
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3315-3330.e7 (2019)
Summary: Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition and dynamics of the PD-1 and BTLA coinhibitory signalosomes in primary e
Externí odkaz:
https://doaj.org/article/aeeda198527f492596a6e85d202556a2
Autor:
Bernard Malissen, Claude Grégoire, Matthias Gstaiger, Frédéric Di Fiore, Ruedi Aebersold, Yunhao Zhai, Kilian Ruminski, Peter Blattmann, Nicolas Jarmuzynski, Javier Celis-Gutierrez, Youcef Ounoughene, Romain Roncagalli
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3315-3330.e7 (2019)
Cell Reports
Cell Reports, 2019, 27 (11), pp.3315+. ⟨10.1016/j.celrep.2019.05.041⟩
Cell Reports, Elsevier Inc, 2019, 27 (11), pp.3315+. ⟨10.1016/j.celrep.2019.05.041⟩
Cell Reports, 27 (11)
Cell Reports
Cell Reports, 2019, 27 (11), pp.3315+. ⟨10.1016/j.celrep.2019.05.041⟩
Cell Reports, Elsevier Inc, 2019, 27 (11), pp.3315+. ⟨10.1016/j.celrep.2019.05.041⟩
Cell Reports, 27 (11)
Summary Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental and clinical interest. Using quantitative interactomics, we define the composition and dynamics of the PD-1 and BTLA coinhibitory signalosomes in primary ef
Autor:
Mylène Camus, Javier Celis-Gutierrez, Romain Roncagalli, Guillaume Voisinne, Odile Burlet-Schiltz, Marie Malissen, Bernard Malissen, Frédéric Di Fiore, Claude Grégoire, Laura Girard, Anne Gonzalez de Peredo, Daiki Mori, Jérémy Argenty, Rudy Aussel, Marlène Marcellin
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 218, ⟨10.1084/jem.20201011⟩
Journal of Experimental Medicine, 2020, 218, ⟨10.1084/jem.20201011⟩
The Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2020, 218, ⟨10.1084/jem.20201011⟩
Journal of Experimental Medicine, 2020, 218, ⟨10.1084/jem.20201011⟩
The Journal of Experimental Medicine
Mori et al. established the composition of the LAT, CD5, and CD6 signalosomes of primary T cells. Positive and negative functions were solely assigned to the LAT and CD5 signalosomes, respectively, whereas the CD6 signalosome conveys antithetical fun
Autor:
Guillaume Voisinne, Bernard Malissen, Laura Girard, Odile Burlet-Schiltz, Daiki Mori, Javier Celis-Gutierrez, Yunhao Zhai, Anne Gonzalez de Peredo, Romain Roncagalli
Publikováno v:
Cellular and molecular immunology
Cellular and molecular immunology, In press, ⟨10.1038/s41423-020-00575-7⟩
Cellular and Molecular Immunology
Cellular & Molecular Immunology
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, In press, ⟨10.1038/s41423-020-00575-7⟩
Cellular and molecular immunology, In press, ⟨10.1038/s41423-020-00575-7⟩
Cellular and Molecular Immunology
Cellular & Molecular Immunology
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, In press, ⟨10.1038/s41423-020-00575-7⟩
International audience; Deciphering how T-cell antigen receptor signals are modulated by coinhibitors is a fundamental goal in immunology and of considerable clinical interest because blocking coinhibitory signals via therapeutic antibodies have beco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b76a9e74476f26ba112ff79d125d7a
https://hal-amu.archives-ouvertes.fr/hal-03086942/document
https://hal-amu.archives-ouvertes.fr/hal-03086942/document
Autor:
Daniel Olive, Marilyn Boyron, Eric Vivier, Javier Celis-Gutierrez, Marc Dalod, Thierry Walzer, Pier Paolo Pandolfi, Jacques A. Nunès, Stipan Jonjić
Publikováno v:
EMBO Journal
EMBO Journal, 2014, 33 (17), pp.1928-40. ⟨10.15252/embj.201387404⟩
The EMBO Journal
Volume 33
Issue 17
EMBO Journal, EMBO Press, 2014, 33 (17), pp.1928-40. ⟨10.15252/embj.201387404⟩
EMBO Journal, 2014, 33 (17), pp.1928-40. ⟨10.15252/embj.201387404⟩
The EMBO Journal
Volume 33
Issue 17
EMBO Journal, EMBO Press, 2014, 33 (17), pp.1928-40. ⟨10.15252/embj.201387404⟩
International audience; Natural killer (NK) cells are involved in immune responses against tumors and microbes. NK-cell activation is regulated by intrinsic and extrinsic mechanisms that ensure NK tolerance and efficacy. Here, we show that the cytopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa81dba32cea9e8cf93e8267aecad5ed
https://www.hal.inserm.fr/inserm-01038075/document
https://www.hal.inserm.fr/inserm-01038075/document
Autor:
Javier Celis-Gutierrez, Nassima Messal, Bruno Chetaille, Aude Sylvain, Emilie Mamessier, Sonia Pastor, Qian Wang, Marie-Laure Thibult, Yves Guillaume, Ivan Hirsch, Jacques A. Nunès, Guylène Firaguay, Daniel Olive
Publikováno v:
European Journal of Immunology
European Journal of Immunology, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (12), pp.3443-54. ⟨10.1002/eji.201141404⟩
European Journal of Immunology, 2011, 41 (12), pp.3443-3454. ⟨10.1002/eji.201141404⟩
International audience; The human butyrophilin (BTN) 3 or CD277 molecules belong to the B7 family members and are expressed in various immune cells such as T and NK cells. Here, we show that CD277 triggering considerably enhances TCR-induced cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142387c5a8b18886265c3eef107fe758
https://doi.org/10.1002/eji.201141404
https://doi.org/10.1002/eji.201141404
Autor:
Frédéric Commo, Sylvie Rusakiewicz, Jean Franãois Emile, Caroline Flament, Jean-Yves Blay, Nicolas Ibrahim, Véronique Minard-Colin, Saadia Kerdine-Römer, Philippe Terrier, Jacques A. Nunès, Cédric Ménard, Pascale Paul, Benedita Rocha, Laurence Zitvogel, Kariman Chaba, Alessandro Moretta, Dominique Valteau-Couanet, Cristina Bottino, Javier Celis Gutierrez, Luc Lyonnet, A. Lecesne, Nathalie Chaput, Stephan Roux, Hélène Authier, Jean Michel Coindre, Matthieu Sarabi, Pascal Rihet, Véronique Baud, Nicolas F. Delahaye, Laetitia Peaudecerf, Isabelle Martins, Sylvie Bonvalot, Jan Tavernier, Eric Vivier, Nicolas Isambert, Michaela Semeraro, Isabelle Cremer, Marc Pallardy, Paule Opolon, Vichnou Poirier-Colame, Guido Kroemer
Publikováno v:
Nature Medicine; Vol 17
Nature Medicine
Nature Medicine, Nature Publishing Group, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩
Nature Medicine, Nature Publishing Group, 2011, 17 (6), pp.700-7. 〈10.1038/nm.2366〉
Nature Medicine, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩
Nature Medicine
Nature Medicine, Nature Publishing Group, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩
Nature Medicine, Nature Publishing Group, 2011, 17 (6), pp.700-7. 〈10.1038/nm.2366〉
Nature Medicine, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩
International audience; The natural killer (NK) cell receptor NKp30 is involved in the recognition of tumor and dendritic cells (DCs). Here we describe the influence of three NKp30 splice variants on the prognosis of gastrointestinal sarcoma (GIST),
Autor:
Philippe Nicolas, Jocelyn Ollier, Daiki Mori, Guillaume Voisinne, Javier Celis-Gutierrez, Claude Gregoire, Jeanne Perroteau, Régine Vivien, Mylène Camus, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Béatrice Clémenceau, Romain Roncagalli, Henri Vié, Bernard Malissen
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, 2022, 219 (2), pp.e20211295. ⟨10.1084/jem.20211295⟩
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2022, 219 (2), pp.e20211295. ⟨10.1084/jem.20211295⟩
The Journal of Experimental Medicine
Nicolas et al. exploited traceable gene tagging in primary human T cells to establish at the systems level the composition and dynamics of TCR-induced signalosomes. It provides a decision-support tool accelerating definition of the mechanism of actio