Genotype-phenotype characterisation of long survivors with motor neuron disease in Scotland

Autor: Danielle J, Leighton, Morad, Ansari, Judith, Newton, David, Parry, Elaine, Cleary, Shuna, Colville, Laura, Stephenson, Juan, Larraz, Micheala, Johnson, Emily, Beswick, Michael, Wong, Jenna, Gregory, Javier, Carod Artal, Richard, Davenport, Callum, Duncan, Ian, Morrison, Colin, Smith, Robert, Swingler, Ian J, Deary, Mary, Porteous, Timothy J, Aitman, Siddharthan, Chandran, George H, Gorrie, Suvankar, Pal, Carolyn, Webber

Publikováno v: Journal of neurology.

We investigated the phenotypes and genotypes of a cohort of 'long-surviving' individuals with motor neuron disease (MND) to identify potential targets for prognostication.Patients were recruited via the Clinical Audit Research and Evaluation for MND

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ad722619f1050ef1243cd81b894e95f
https://pubmed.ncbi.nlm.nih.gov/36515702

A systematic review of European regional and national guidelines: a focus on the recommended use of nabiximols in the management of spasticity in multiple sclerosis

Autor: Francisco Javier Carod-Artal, Peyman Adjamian, Carlos Vila Silván, Makarand Bagul, Claudio Gasperini

Publikováno v: Expert review of neurotherapeutics. 22(6)

Spasticity is a common, debilitating symptom of multiple sclerosis (MS) with several treatment options including the cannabinoid-based treatment, nabiximols. The purpose of this review was to examine the existing clinical practice guidelines that dir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ae8e7ebad3318f4114657ea503217c
https://pubmed.ncbi.nlm.nih.gov/35582858

Network analysis characterizes key associations between subjective fatigue and specific depressive symptoms in early relapsing-remitting multiple sclerosis

Autor: Yuan-Ting Chang, Patrick K.A. Kearns, Alan Carson, David C. Gillespie, Rozanna Meijboom, Agniete Kampaite, Maria del C. Valdés Hernández, Christine Weaver, Amy Stenson, Niall MacDougall, Jonathan O'Riordan, Margaret Ann Macleod, Francisco Javier Carod-Artal, Peter Connick, Adam D. Waldman, Siddharthan Chandran, Peter Foley

Publikováno v: Chang, Y, Kearns, P K A, Carson, A, Gillespie, D C, Meijboom, R, Kampaite, A, Valdés Hernández, M D C, Weaver, C, Stenson, A, Macdougall, N, O'riordan, J, Macleod, M A, Carod-artal, F J, Connick, P, Waldman, A D, Chandran, S & Foley, P 2022, ' Network analysis characterizes key associations between subjective fatigue and specific depressive symptoms in early relapsing-remitting multiple sclerosis ', Multiple Sclerosis and Related Disorders, vol. 69, pp. 104429 . https://doi.org/10.1016/j.msard.2022.104429

Fatigue is common and disabling in multiple sclerosis (MS), yet its mechanisms are poorly understood. In particular, overlap in measures of fatigue and depression complicates interpretation. We applied a multivariate network approach to quantify rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a528ac76823d0415509d0442b713482c
https://doi.org/10.1016/j.msard.2022.104429

Demência por neurossífilis: evolução clínica e neuropsicológica de um paciente

Autor: ANTONIO PEDRO VARGAS, FRANCISCO JAVIER CAROD-ARTAL, MARIA CRISTINA DEL NEGRO, MAIRA PINTO CAUCHIOLI RODRIGUES

Publikováno v: Arquivos de Neuro-Psiquiatria, Vol 58, Iss 2B, Pp 578-582 (2000)

Demência é uma das manifestações da sífilis tardia e caracteriza-se por deterioração cognitiva e alteração do comportamento. Descrevemos um paciente com declínio cognitivo, alterações na personalidade, hiperatividade, alucinações, delí

Externí odkaz: https://doaj.org/article/a21b3c7930ea4296839a8e4fefa3952c

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective

Autor: Robert Swingler, Nigel Leigh, Christine Weaver, Nigel Stallard, Amina Chaouch, Dawn Lyle, Francisco Javier Carod-Artal, Suvankar Pal, Richard A Parker, Ian Morrison, Hisham Hamdalla, Amy Stenson, Pablo Garcia Reitboeck, Jenny Preston, Venkataramanan Srinivasan, Ashwin Pinto, Judith Newton, Stella A. Glasmacher, Arpan R Mehta, Rachel Dakin, Callum Duncan, Aleksandar Radunovic, Siddharthan Chandran, Richard Davenport, Jeremy Chataway, Elizabeth Elliott, Maria Stavrou, John Ealing, Tim Williams, Jenna M. Gregory, George Gorrie, Mahesh K. B. Parmar, Charis Wong, Emily Beswick, Jill M Williamson, Danielle Leighton, Christopher J. Weir, Malcolm R. Macleod, Peter J. Connelly

Publikováno v: Brain Communications
Wong, C, Stavrou, M, Elliott, L, Gregory, J, Leigh, P N, Pinto, A, Williams, T, Chataway, J, Swingler, R, Parmar, M K B, Stallard, N, Weir, C J, Parker, R A, Chaouch, A, Hamdalla, H, Ealing, J, Gorrie, G, Morrison, I, Duncan, C, Connelly, P, Javier Carod-Artal, F, Davenport, R, Reitboeck, P G, Radunovic, A, Srinivasan, V, Preston, J, Mehta, A, Leighton, D, Glasmacher, S, Beswick, E, Williamson, J, Stenson, A, Weaver, C, Newton, J, Lyle, D, Dakin, R S, MacLeod, M, Pal, S & Chandran, S 2021, ' Clinical trials in amyotrophic lateral sclerosis : a systematic review and perspective ', Brain Communications, vol. 3, no. 4 . https://doi.org/10.1093/braincomms/fcab242, https://doi.org/10.1093/braincomms/fcab242

Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite decades of clinical trials, effective disease-modifying drugs remain scarce. To understand the challenges of trial design and delivery, we performed a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91afba6db5d18614e79af23fbeb9ff09
https://pubmed.ncbi.nlm.nih.gov/34901853