Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Javier Calvo‐Garrido"'
Autor:
Paula Clemente, Javier Calvo-Garrido, Sarah F. Pearce, Florian A. Schober, Megumi Shigematsu, Stefan J. Siira, Isabelle Laine, Henrik Spåhr, Christian Steinmetzger, Katja Petzold, Yohei Kirino, Rolf Wibom, Oliver Rackham, Aleksandra Filipovska, Joanna Rorbach, Christoph Freyer, Anna Wredenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
A subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts
Externí odkaz:
https://doaj.org/article/72badb54eeff4560ac9bcd8f356122f9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/d07081d6fc7544c3bb4631b98be0631b
Autor:
Javier Calvo-Garrido, Dania Winn, Camilla Maffezzini, Anna Wedell, Christoph Freyer, Anna Falk, Anna Wredenberg
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100528- (2021)
Summary: Here, we present a revised protocol to derive neuroepithelial stem (NES) cells from human induced pluripotent stem cells. NES cells can be further differentiated into a culture of neurons (90%) and glia (10%). We describe how to derive and m
Externí odkaz:
https://doaj.org/article/d5ef0141d17c4911a6a0bf620bcf9ffc
Autor:
Javier Calvo-Garrido, Camilla Maffezzini, Florian A. Schober, Paula Clemente, Elias Uhlin, Malin Kele, Henrik Stranneheim, Nicole Lesko, Helene Bruhn, Per Svenningsson, Anna Falk, Anna Wedell, Christoph Freyer, Anna Wredenberg
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 696-711 (2019)
Summary: Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases w
Externí odkaz:
https://doaj.org/article/325a48b5ac9c47b4bce704a2ebf2353e
Autor:
Aleksandra Pajak, Isabelle Laine, Paula Clemente, Najla El-Fissi, Florian A Schober, Camilla Maffezzini, Javier Calvo-Garrido, Rolf Wibom, Roberta Filograna, Ashish Dhir, Anna Wedell, Christoph Freyer, Anna Wredenberg
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008240 (2019)
The RNA helicase SUV3 and the polynucleotide phosphorylase PNPase are involved in the degradation of mitochondrial mRNAs but their roles in vivo are not fully understood. Additionally, upstream processes, such as transcript maturation, have been link
Externí odkaz:
https://doaj.org/article/ea7ce131776e4971ad749d7f42cbb85b
Autor:
Camilla Maffezzini, Isabelle Laine, Cristina Dallabona, Paula Clemente, Javier Calvo‐Garrido, Rolf Wibom, Karin Naess, Michela Barbaro, Anna Falk, Claudia Donnini, Christoph Freyer, Anna Wredenberg, Anna Wedell
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Background Mutations in mitochondrial aminoacyl tRNA synthetases form a subgroup of mitochondrial disorders often only perturbing brain function by affecting mitochondrial translation. Here we report two siblings with mitochondrial disease,
Externí odkaz:
https://doaj.org/article/03c8ed8ecf954de0830b33db66f79e60
Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation.
Autor:
Ana Bratic, Paula Clemente, Javier Calvo-Garrido, Camilla Maffezzini, Andrea Felser, Rolf Wibom, Anna Wedell, Christoph Freyer, Anna Wredenberg
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006028 (2016)
Polyadenylation has well characterised roles in RNA turnover and translation in a variety of biological systems. While polyadenylation on mitochondrial transcripts has been suggested to be a two-step process required to complete translational stop co
Externí odkaz:
https://doaj.org/article/257f25870f65415ca39d229a709091a7
Publikováno v:
Cellular and Molecular Life Sciences
Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation
Autor:
Camilla Maffezzini, Anna Falk, Dania Winn, Javier Calvo-Garrido, Anna Wedell, Anna Wredenberg, Christoph Freyer
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100528-(2021)
STAR Protocols
STAR Protocols
Summary Here, we present a revised protocol to derive neuroepithelial stem (NES) cells from human induced pluripotent stem cells. NES cells can be further differentiated into a culture of neurons (90%) and glia (10%). We describe how to derive and ma
Autor:
Anna Wredenberg, Paula Clemente, Christoph Freyer, Anna Wedell, Elias Uhlin, Camilla Maffezzini, Henrik Stranneheim, Nicole Lesko, Florian A. Schober, Malin Kele, Per Svenningsson, Javier Calvo-Garrido, Anna Falk, Helene Bruhn
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 12, Iss 4, Pp 696-711 (2019)
Stem Cell Reports, Vol 12, Iss 4, Pp 696-711 (2019)
Summary Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases wi