Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Javier Barallobre-Barreiro"'
Autor:
Manar Elkenani, Javier Barallobre-Barreiro, Moritz Schnelle, Belal A. Mohamed, Bo E. Beuthner, Christoph Friedemann Jacob, Niels B. Paul, Xiaoke Yin, Konstantinos Theofilatos, Andreas Fischer, Miriam Puls, Elisabeth M. Zeisberg, Ajay M. Shah, Manuel Mayr, Gerd Hasenfuß, Karl Toischer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
AimsPatients with severe aortic stenosis (AS), low transvalvular flow (LF) and low gradient (LG) with normal ejection fraction (EF)—are referred to as paradoxical LF-LG AS (PLF-LG). PLF-LG patients develop more advanced heart failure symptoms and h
Externí odkaz:
https://doaj.org/article/66c50dcf5e0d438197600afb3e70ea8d
Autor:
Irina Zalivina, Temo Barwari, Xiaoke Yin, Sarah R. Langley, Javier Barallobre-Barreiro, Hiroko Wakimoto, Anna Zampetaki, Manuel Mayr, Metin Avkiran, Seda Eminaga
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100056- (2023)
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder, characterized by cardiomyocyte hypertrophy, cardiomyocyte disarray and fibrosis, which has a prevalence of ∼1: 200–500 and predisposes individuals to heart f
Externí odkaz:
https://doaj.org/article/b8223816a67346999e77b33054cf0c71
Autor:
Elisa Duregotti, Christina M. Reumiller, Ursula Mayr, Maria Hasman, Lukas E. Schmidt, Sean A. Burnap, Konstantinos Theofilatos, Javier Barallobre-Barreiro, Arne Beran, Maria Grandoch, Alessandro Viviano, Marjan Jahangiri, Manuel Mayr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Adipose tissue is an important secretory organ, but less is known about the secretory activity of perivascular fat. Here the authors use proteomics analysis on secretomes from perivascular fat to identify neuronal growth regulator 1 as an adipocyte-d
Externí odkaz:
https://doaj.org/article/314f652efb89427593b06c3be4c7327b
Autor:
Ella Reed, Adam Fellows, Ruifang Lu, Marieke Rienks, Lukas Schmidt, Xiaoke Yin, Elisa Duregotti, Mona Brandt, Susanne Krasemann, Kristin Hartmann, Javier Barallobre-Barreiro, Owen Addison, Friederike Cuello, Arne Hansen, Manuel Mayr
Publikováno v:
Matrix Biology Plus, Vol 16, Iss , Pp 100122- (2022)
Aortic smooth muscle cells (SMCs) have an intrinsic role in regulating vessel homeostasis and pathological remodelling. In two-dimensional (2D) cell culture formats, however, SMCs are not embedded in their physiological extracellular matrix (ECM) env
Externí odkaz:
https://doaj.org/article/580ca8a960804e2e8115303fc00c8289
Autor:
Daniel Brayson, So‐Jin Holohan, Sonya C. Bardswell, Matthew Arno, Han Lu, Hanna K. Jensen, Phan Kiet Tran, Javier Barallobre‐Barreiro, Manuel Mayr, Cristobal G. dos Remedios, Victor T. Tsang, Alessandra Frigiola, Jonathan C. Kentish
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 16 (2020)
Background Patients with repair of tetralogy of Fallot (rToF) who are approaching adulthood often exhibit pulmonary valve regurgitation, leading to right ventricle (RV) dilatation and dysfunction. The regurgitation can be corrected by pulmonary valve
Externí odkaz:
https://doaj.org/article/9b352784f7f947f58b51bb7e70bafd99
Autor:
Javier Barallobre-Barreiro, Elizabeth Woods, Rachel E. Bell, Jennifer A. Easton, Carl Hobbs, Michael Eager, Ferheen Baig, Alastair Mackenzie Ross, Raj Mallipeddi, Barry Powell, Mark Soldin, Manuel Mayr, Tanya J. Shaw
Publikováno v:
Matrix Biology Plus, Vol 4, Iss , Pp - (2019)
Following wound damage to the skin, the scarring spectrum is wide-ranging, from a manageable normal scar through to pathological keloids. The question remains whether these fibrotic lesions represent simply a quantitative extreme, or alternatively, w
Externí odkaz:
https://doaj.org/article/391237161bde4e3884eee87ed35e9807
Autor:
Mariana Fernández-Caggiano, Javier Barallobre-Barreiro, Ignacio Rego-Pérez, María G Crespo-Leiro, María Jesus Paniagua, Zulaika Grillé, Francisco J Blanco, Nieves Doménech
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44128 (2012)
BackgroundSince mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may influence this disease. The aim of the prese
Externí odkaz:
https://doaj.org/article/64a8991c07a04cb59d6e5d1e51324d48
Autor:
Konstantinos Theofilatos, Manuel Mayr, Norman Catibog, Nieves Doménech, B Merkely, Ruifang Lu, María G. Crespo-Leiro, Ferheen Baig, Javier Barallobre-Barreiro, Eric L. Lindberg, Marika Fava, Elisa Duregotti, Bhawana Singh, Ajay M. Shah, Tamás Radovits, Aleksandra Malgorzata Siedlar, Friederike Cuello, Ursula Mayr, Lukas E Schmidt, Diego Martínez-López, Wen-Yu Lin, László Daróczi, Maria Hasman, Norbert Hubner, Elizaveta Ermolaeva
Publikováno v:
RUC. Repositorio da Universidade da Coruña
instname
Circulation
instname
Circulation
Supplemental Digital Content is available in the text.
Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disinte
Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disinte
Autor:
Michael Böhm, Jan-Christian Reil, Manuel Mayr, Christoph Maack, Thomas Hübschle, Thorsten Sadowski, Alexander Nickel, Claudia Goettsch, Benedikt Linz, Sven Ruf, Thimoteus Speer, Dominik Linz, Simina-Ramona Selejan, Javier Barallobre-Barreiro, Xiaoke Yin, Claudia Fecher-Trost, Lisa Lang, Katharina Erb, Mathias Hohl
Publikováno v:
Journal of Biological Chemistry, 295(36), 12605-12617. American Society for Biochemistry and Molecular Biology, Inc.
Hohl, M, Mayr, M, Lang, L, Nickel, A G, Barallobre-Barreiro, J, Yin, X, Speer, T, Selejan, S-R, Goettsch, C, Erb, K, Fecher-Trost, C, Reil, J-C, Linz, B, Ruf, S, Huebschle, T, Maack, C, Boehm, M, Sadowski, T & Linz, D 2020, ' Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12605-12617 . https://doi.org/10.1074/jbc.RA120.013488
J Biol Chem
Hohl, M, Mayr, M, Lang, L, Nickel, A G, Barallobre-Barreiro, J, Yin, X, Speer, T, Selejan, S-R, Goettsch, C, Erb, K, Fecher-Trost, C, Reil, J-C, Linz, B, Ruf, S, Huebschle, T, Maack, C, Boehm, M, Sadowski, T & Linz, D 2020, ' Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12605-12617 . https://doi.org/10.1074/jbc.RA120.013488
J Biol Chem
In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM). CatA-mediated degradation of extracellular peptides may contribute to ECM remodeling and left ventricular (LV) dysfuncti
Autor:
Raimund Pechlaner, Thomas Toell, Paul Perco, Christian Boehme, Johann Willeit, Lukas Mayer, Javier Barallobre-Barreiro, Michael Knoflach, Manuel Mayr, Stefan Kiechl, Xiaoke Yin, Elke R. Gizewski, Gudrun Ratzinger, Marc Lynch
Publikováno v:
Neurology. 95:e2047-e2055
ObjectiveTo assess whether connective tissue disorder is evident in patients with spontaneous cervical artery dissection and therefore identify patients at risk of recurrence using a cutting-edge quantitative proteomics approach.MethodsIn the ReSect