Výsledky vyhledávání - "Javier Alguacil"

Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA

Autor: Jordi Robles, Javier Alguacil, Elisabeth Bosch, Clara Ràfols

Publikováno v: Journal of Molecular Recognition. 29:142-150

Isothermal titration calorimetry (ITC) is a powerful technique able to evaluate the energetics of target-drug binding within the context of drug discovery. In this work, the interactions of RNAs reproducing bacterial and human ribosomal A-site, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0083b736c2783bec383dfe463481aa8a
https://doi.org/10.1002/jmr.2513

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Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens

Autor: Eric Champagne, Asmaa Mehtougui, Erin J. Adams, Javier Alguacil, Suzanne Peyrottes, Morgane Moulin, Siyi Gu

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (23), pp.4353-4367. ⟨10.1007/s00018-017-2583-0⟩

Human Vγ9Vδ2 T cells can sense through their TCR tumor cells producing the weak endogenous phosphorylated antigen isopentenyl pyrophosphate (IPP), or bacterially infected cells producing the strong agonist hydroxyl dimethylallyl pyrophosphate (HDMA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229074718b17c9fc35e3449b5a26162c
https://hal.archives-ouvertes.fr/hal-02408365

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RNA recognition and self-association of CPEB4 is mediated by its tandem RRM domains

Autor: James M. B. Gordon, Maria J. Macias, Enrique Pedroso, Constanze Schelhorn, Lidia Ruiz, Javier Alguacil

Publikováno v: Nucleic Acids Research

Cytoplasmic polyadenylation is regulated by the interaction of the cytoplasmic polyadenylation element binding proteins (CPEB) with cytoplasmic polyadenylation element (CPE) containing mRNAs. The CPEB family comprises four paralogs, CPEB1–4, each c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a820399f0456e69562c288b8caa4e3b
https://doi.org/10.1093/nar/gku700

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Exploring synthetic pathways for nucleosidic derivatives of potent phosphoantigens

Autor: Béatrice Roy, Suzanne Peyrottes, Javier Alguacil, Christian Périgaud, David Reyes, Yoann Aubin, Eric Champagne

Publikováno v: New Journal of Chemistry
New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.6046-6052. ⟨10.1039/c5nj03614c⟩
New Journal of Chemistry, 2016, 40 (7), pp.6046-6052. ⟨10.1039/c5nj03614c⟩

The comparative study of two synthetic pathways for nucleoside phosphoantigens is reported herein. The first using esterification of the γ-phosphate of ATP is leading to low yields whereas the coupling of ADP–imidazolate intermediate with a monoph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5fcff513fc4f29f364464e31ed05e2
https://hal.archives-ouvertes.fr/hal-02408371

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A Straightforward Preparation of Aminoglycoside-Dinucleotide and -diPNA Conjugates via Click Ligation Assisted by Microwaves

Autor: Javier Alguacil, Sira Defaus, Marta Masides, Jordi Robles, Alejandro Trapote, Ana Claudio

Publikováno v: European Journal of Organic Chemistry. 2010:3102-3109

An alternative and straightforward method to prepare aminoglycoside–dinucleotide and –diPNA conjugates is reported, which is based on copper-catalyzed Huisgen azide-alkyne cycloaddition (“click chemistry” ligation) assisted by microwave irrad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::345cd83c5cfb053534a789d3344c0b0a
https://doi.org/10.1002/ejoc.201000182

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Novel oligonucleotide analogues containing a morpholinoamidine unit

Autor: Javier Alguacil, Jordi Robles, Sónia Pérez-Rentero

Publikováno v: Tetrahedron. 65:1171-1179

Morpholinoamidines were devised as new cationic units in oligonucleotides, by combining morpholino-nucleosides (to simplify the nomenclature, we will use the term morpholino-nucleosides to refer to nucleoside analogues in which the ribose ring was tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51429eed5b6f38824742a42e529fc575
https://doi.org/10.1016/j.tet.2008.11.069

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Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA

Autor: Javier, Alguacil, Jordi, Robles, Clara, Ràfols, Elisabeth, Bosch

Publikováno v: Journal of molecular recognition : JMR. 29(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::703545f8515c4e1aa8c09e7b1ddd7c89
https://pubmed.ncbi.nlm.nih.gov/26530431

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A single-molecule force spectroscopy nanosensor for the identification of new antibiotics and antimalarials

Autor: Jordi Robles, Xavier Sisquella, Javier Alguacil, Fausto Sanz, Xavier Fernàndez-Busquets, Dario Anselmetti, Santiago Imperial, Karel de Pourcq

An important goal of nanotechnology is the application of individual molecule handling techniques to the discovery of potential new therapeutic agents. Of particular interest is the search for new inhibitors of metabolic routes exclusive of human pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91de5b0528713fe89ed088ff800c1908
https://pub.uni-bielefeld.de/record/1929244

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