Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Javier, Vitorica"'
Autor:
Laura Cáceres Palomo, Juan García León, Laura Trujillo Estrada, Elba López Oliva, Javier Vitorica, Antonia Gutierrez
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S170- (2023)
Externí odkaz:
https://doaj.org/article/1285cd4ea93548d9ac93644d3a86fa69
Autor:
Marina Mejias-Ortega, Clara Muñoz-Castro, Elisabet Sanchez-Mejias, Sebastian Jimenez, Laura Trujillo-Estrada, Marisa Vizuete, Javier Vitorica, Antonia Gutierrez
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S450- (2023)
Externí odkaz:
https://doaj.org/article/e6a22f48faf84a9aae057805cce3cc8a
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S502- (2023)
Externí odkaz:
https://doaj.org/article/1029a361de844a54a958e976f533fce9
Autor:
Clara Muñoz-Castro, Marina Mejias-Ortega, Elisabeth Sanchez-Mejias, Victoria Navarro, Laura Trujillo-Estrada, Sebastian Jimenez, Juan Antonio Garcia-Leon, Juan Jose Fernandez-Valenzuela, Maria Virtudes Sanchez-Mico, Carmen Romero-Molina, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the contribution of nonparenchymal or brain-infiltrated myeloid cells to di
Externí odkaz:
https://doaj.org/article/4356ba8ee739486f92b38c01b92e57e2
Autor:
Natalia Salvadores, Ines Moreno-Gonzalez, Nazaret Gamez, Gabriel Quiroz, Laura Vegas-Gomez, Marcela Escandón, Sebastian Jimenez, Javier Vitorica, Antonia Gutierrez, Claudio Soto, Felipe A. Court
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports point amyloid-β (Aβ) as the main etiologic agent that triggers AD. Although there is extensive evidence of detrim
Externí odkaz:
https://doaj.org/article/fededd33034440f988ac2569fa67e475
Autor:
Maria I. Alvarez-Vergara, Alicia E. Rosales-Nieves, Rosana March-Diaz, Guiomar Rodriguez-Perinan, Nieves Lara-Ureña, Clara Ortega-de San Luis, Manuel A. Sanchez-Garcia, Miguel Martin-Bornez, Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Beatriz Fernandez-Gomez, Miguel A. Marchena, Andrea S. Bullones-Bolanos, Jose C. Davila, Rocio Gonzalez-Martinez, Jose L. Trillo-Contreras, Ana C. Sanchez-Hidalgo, Raquel del Toro, Francisco G. Scholl, Eloisa Herrera, Martin Trepel, Jakob Körbelin, Luis M. Escudero, Javier Villadiego, Miriam Echevarria, Fernando de Castro, Antonia Gutierrez, Alberto Rabano, Javier Vitorica, Alberto Pascual
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced pres
Externí odkaz:
https://doaj.org/article/65297e3308ba45ef8cbc879a7f19dfe0
Autor:
Mercedes M. Pérez-Jiménez, José M. Monje-Moreno, Ana María Brokate-Llanos, Mónica Venegas-Calerón, Alicia Sánchez-García, Paula Sansigre, Amador Valladares, Sara Esteban-García, Irene Suárez-Pereira, Javier Vitorica, José Julián Ríos, Marta Artal-Sanz, Ángel M. Carrión, Manuel J. Muñoz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.
Externí odkaz:
https://doaj.org/article/873769f1ad43491084d967f67bef724d
Autor:
Raquel Larramona-Arcas, Candela González-Arias, Gertrudis Perea, Antonia Gutiérrez, Javier Vitorica, Tamara García-Barrera, José Luis Gómez-Ariza, Raquel Pascua-Maestro, María Dolores Ganfornina, Eleanna Kara, Eloise Hudry, Marta Martinez-Vicente, Miquel Vila, Elena Galea, Roser Masgrau
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-23 (2020)
Abstract Background The apolipoprotein E (APOE) gene exists in three isoforms in humans: APOE2, APOE3 and APOE4. APOE4 causes structural and functional alterations in normal brains, and is the strongest genetic risk factor of the sporadic form of Alz
Externí odkaz:
https://doaj.org/article/d54845f1ed0141cba4bad31da880a522
Autor:
María García-Bonilla, Betsaida Ojeda-Pérez, María L. García-Martín, M. Carmen Muñoz-Hernández, Javier Vitorica, Sebastián Jiménez, Manuel Cifuentes, Leonor Santos-Ruíz, Kirill Shumilov, Silvia Claros, Antonia Gutiérrez, Patricia Páez-González, Antonio J. Jiménez
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-20 (2020)
Abstract Background In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions i
Externí odkaz:
https://doaj.org/article/fbb0e27d4a724efe9eef7178444de300
Autor:
Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Juan Jose Fernandez-Valenzuela, Vanessa De Castro, Marina Mejias-Ortega, Angela Gomez-Arboledas, Sebastian Jimenez, Maria Virtudes Sanchez-Mico, Laura Trujillo-Estrada, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological features that best co
Externí odkaz:
https://doaj.org/article/8efa1e12f990456da15d700c8c5ad782