Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Javier, Sastre Toraño"'
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Akademický článek
Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry
Autor: Gaёl M. Vos, Kevin C. Hooijschuur, Zeshi Li, John Fjeldsted, Christian Klein, Robert P. de Vries, Javier Sastre Toraño, Geert-Jan Boons
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract O-acetylation is a common modification of sialic acids that has been implicated in a multitude of biological and disease processes. A lack of analytical methods that can determine exact structures of sialic acid variants is a hurdle to deter
Externí odkaz: https://doaj.org/article/033979f4999e416c953fd011e0e3a6b2
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4
Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor
Autor: Albert J. R. Heck, John A. W. Kruijtzer, Tiehai Li, Tomislav Čaval, Javier Sastre Toraño, Geert-Jan Boons, Ivan A. Gagarinov, Apoorva D. Srivastava
Publikováno v: Journal of the American Chemical Society. 139:1011-1018
Progress in glycoscience is hampered by a lack of well-defined complex oligosaccharide standards that are needed to fabricate the next generation of microarrays, to develop analytical protocols to determine exact structures of isolated glycans, and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01acbf33c85e439cb31bb07438512088
https://doi.org/10.1021/jacs.6b12080
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5
Quantitative Translation of Microfluidic Transporter
Autor: Thomas K, van der Made, Michele, Fedecostante, Daniel, Scotcher, Amin, Rostami-Hodjegan, Javier, Sastre Toraño, Igor, Middel, Andries S, Koster, Karin G, Gerritsen, Vera, Jankowski, Joachim, Jankowski, Joost G J, Hoenderop, Rosalinde, Masereeuw, Aleksandra, Galetin
Publikováno v: Molecular pharmaceutics. 16(11)
Indoxyl sulfate (IxS), a highly albumin-bound uremic solute, accumulates in chronic kidney disease (CKD) due to reduced renal clearance. This study was designed to specifically investigate the role of human serum albumin (HSA) in IxS renal secretion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3e174667ba0e47bb91c69c3e67e09535
https://pubmed.ncbi.nlm.nih.gov/31525064
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7
Orthoester functionalized
Autor: Alen, Sevšek, Javier, Sastre Toraño, Linda, Quarles van Ufford, Ed E, Moret, Roland J, Pieters, Nathaniel I, Martin
Publikováno v: MedChemComm. 8(11)
Alkylated guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol bearing an orthoester moiety were prepared using a concise synthetic protocol. Inhibition assays with a panel of glycosidases revealed that one of the compounds prepared displays pote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15a8b983bb1d54fdfd7ab6121e6e0cbb
https://pubmed.ncbi.nlm.nih.gov/30108721
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8
Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine
Autor: Govert W. Somsen, Javier Sastre Toraño, David Moreno-González, Gerhardus J. de Jong, Ana M. García-Campaña, Laura Gámiz-Gracia
Publikováno v: Electrophoresis, 34, 2615-2622. Wiley-VCH Verlag
Moreno-Gonzalez, D, Sastre Torano, J, Gamiz-Garcia, L, Garcia-Campana, A M, de Jong, G J & Somsen, G W 2013, ' Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine ', Electrophoresis, vol. 34, pp. 2615-2622 . https://doi.org/10.1002/elps.201300247
A new MEKC-ESI-MS method for the analysis of amino acids (AAs) in human urine was developed employing ammonium perfluorooctanoate (APFO) as volatile surfactant. The influence of APFO on the MS signal of AAs was evaluated by infusion experiments, whic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f5c2d623cb29938505039b07a3a75c
https://doi.org/10.1002/elps.201300247
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9
The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic minipump studies
Autor: Javier Sastre Toraño, Elsebet Ø. Nielsen, Gerhardus J. de Jong, Christiaan H. Vinkers, Naheed R. Mirza, Philip K. Ahring, Berend Olivier, Gerdien A.H. Korte-Bouws
Publikováno v: Psychopharmacology
Background In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solution has been described. This would dim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5f05c9b24ee808d797aefd57861314
https://doi.org/10.1007/s00213-009-1752-8
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10
Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis
Autor: Peter M.J.M. Jongen, Govert W. Somsen, Javier Sastre Toraño, Yvonne H. Tak, Gerhardus J. de Jong
Publikováno v: Journal of Chromatography A, 1216(18), 4107-4112. Elsevier
Somsen, G W, Tak, Y H, Torano, J S, Jongen, P M J M & de Jong, G J 2009, ' Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis ', Journal of Chromatography A, vol. 1216, no. 18, pp. 4107-4112 . https://doi.org/10.1016/j.chroma.2009.02.063
Recently, oversulfated chondroitin sulfate (OSCS) present in certain lots of heparin was identified as the toxic contaminant responsible for severe side effects following intravenous heparin administration. The United States Pharmacopeia (USP) and Eu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab707ce25654e2edc5f83f00a61608e
https://hdl.handle.net/1871.1/ca005674-9466-41f7-ab82-647289515d6c
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