Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Javad Golji"'
Autor:
Inês A. M. Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P. Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, Tobias Schmelzle, Giorgio G. Galli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-function mutations in upstream components of the Hippo p
Externí odkaz:
https://doaj.org/article/e2b59d291ce047f9846c8773ccba1759
Autor:
Hasmik Keshishian, E Robert McDonald III, Filip Mundt, Randy Melanson, Karsten Krug, Dale A Porter, Luke Wallace, Dominique Forestier, Bokang Rabasha, Sara E Marlow, Judit Jane‐Valbuena, Ellen Todres, Harrison Specht, Margaret Lea Robinson, Pierre M Jean Beltran, Ozgun Babur, Meagan E Olive, Javad Golji, Eric Kuhn, Michael Burgess, Melanie A MacMullan, Tomas Rejtar, Karen Wang, DR Mani, Shankha Satpathy, Michael A Gillette, William R Sellers, Steven A Carr
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here, we present SigPath, a targeted mas
Externí odkaz:
https://doaj.org/article/8c21ac714ff142d89c9c58dde8847a35
Autor:
Antoine de Weck, Javad Golji, Michael D Jones, Joshua M Korn, Eric Billy, E Robert McDonald, Tobias Schmelzle, Hans Bitter, Audrey Kauffmann
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 7, p e1006279 (2018)
Cell autonomous cancer dependencies are now routinely identified using CRISPR loss-of-function viability screens. However, a bias exists that makes it difficult to assess the true essentiality of genes located in amplicons, since the entire amplified
Externí odkaz:
https://doaj.org/article/e74cc4203edf4db5a19da535576505dc
Autor:
Javad Golji, Mohammad R K Mofrad
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 4, p e1002995 (2013)
Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal adhesions and also in capping of actin filaments to regulate actin dynamics. Using molecular dynamics, both interactions are simulated using different vinc
Externí odkaz:
https://doaj.org/article/b7bdcfb925ee4e20b4af0812c92d142a
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 5, p e1000389 (2009)
alpha-Actinin is an actin crosslinking molecule that can serve as a scaffold and maintain dynamic actin filament networks. As a crosslinker in the stressed cytoskeleton, alpha-actinin can retain conformation, function, and strength. alpha-Actinin has
Externí odkaz:
https://doaj.org/article/63467b50e97348d7af9a1cff2ccfa623
Autor:
Matthew J. Meyer, Darrin D. Stuart, Juliet A. Williams, Hui Gao, Jane Gu, Felipe C. Geyer, Daniel P. Rakiec, David A. Ruddy, Xiamei Zhang, Ailing Li, Javad Golji, Tianshu Feng
Inhibitors targeting BRAF and its downstream kinase MEK produce robust response in patients with advanced BRAFV600-mutant melanoma. However, the duration and depth of response vary significantly between patients; therefore, predicting response a prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::107306fe871b3bcf40d98383381828ba
https://doi.org/10.1158/1535-7163.c.6538579.v1
https://doi.org/10.1158/1535-7163.c.6538579.v1
Autor:
Matthew J. Meyer, Darrin D. Stuart, Juliet A. Williams, Hui Gao, Jane Gu, Felipe C. Geyer, Daniel P. Rakiec, David A. Ruddy, Xiamei Zhang, Ailing Li, Javad Golji, Tianshu Feng
BRAFV600 mutant melanoma PDXs exhibit varied degrees of MAPK pathway suppression upon BRAF and MEK inhibitor treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e9cd4c7279befd5812e90c5288a863
https://doi.org/10.1158/1535-7163.22507099.v1
https://doi.org/10.1158/1535-7163.22507099.v1
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Correlation analysis matrix displaying features that correlate most strongly with sgRNA's having off target effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7173657ab8c9cebbe2e61d7645ea2b63
https://doi.org/10.1158/2159-8290.22531563.v1
https://doi.org/10.1158/2159-8290.22531563.v1
Autor:
Matthew J. Meyer, Darrin D. Stuart, Juliet A. Williams, Hui Gao, Jane Gu, Felipe C. Geyer, Daniel P. Rakiec, David A. Ruddy, Xiamei Zhang, Ailing Li, Javad Golji, Tianshu Feng
List of genes from the DEG clustering analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9d56c1e9d561a3296f51346510bda5
https://doi.org/10.1158/1535-7163.22507087.v1
https://doi.org/10.1158/1535-7163.22507087.v1
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53e60107d91f1fd9557bb4a74a377e
https://doi.org/10.1158/2159-8290.22531569
https://doi.org/10.1158/2159-8290.22531569