Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Javad, Garousi"'
Autor:
Sergey M. Deyev, Maryam Oroujeni, Javad Garousi, Torbjörn Gräslund, Ruonan Li, Alia Hani Binti Rosly, Anna Orlova, Elena Konovalova, Alexey Schulga, Anzhelika Vorobyeva, Vladimir Tolmachev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4246 (2024)
Designed ankyrin repeat protein (DARPin) G3 is an engineered scaffold protein. This small (14.5 kDa) targeting protein binds with high affinity to human epidermal growth factor receptor 2 (HER2). HER2 is overexpressed in several cancers. The use of t
Externí odkaz:
https://doaj.org/article/12a7cc2e5d4d4661b07a0431cf300507
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-26 (2020)
Abstract The use of radiolabelled antibodies was proposed in 1970s for staging of malignant tumours. Intensive research established chemistry for radiolabelling of proteins and understanding of factors determining biodistribution and targeting proper
Externí odkaz:
https://doaj.org/article/db42c34e5db84f77bcac563b3d23119c
Autor:
Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev, Anzhelika Vorobyeva
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Background Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPin
Externí odkaz:
https://doaj.org/article/1cdec13355ae4c87aaae315f15791931
Autor:
Mariia Larkina, Evgenii Plotnikov, Ekaterina Bezverkhniaia, Yulia Shabanova, Maria Tretyakova, Feruza Yuldasheva, Roman Zelchan, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Javad Garousi, Torbjörn Gräslund, Mikhail Belousov, Vladimir Tolmachev, Sergey Deyev
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13443 (2022)
Non-invasive radionuclide imaging of human epidermal growth factor receptor type 2 (HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients for treatment using HER2-targeted therapeutics. Designed ankyrin repeat protei
Externí odkaz:
https://doaj.org/article/b1a64337c5e043cb8be0635e815b0d3f
Autor:
Javad Garousi, Tianqi Xu, Yongsheng Liu, Olga Vorontsova, Sophia Hober, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1612 (2022)
Overexpression of the human epidermal growth factor receptor 2 (HER2) in breast and gastric cancer is exploited for targeted therapy using monoclonal antibodies and antibody-drug conjugates. Small engineered scaffold proteins, such as the albumin bin
Externí odkaz:
https://doaj.org/article/83042476b5c341b3a510e83a30a5302f
Autor:
Javad Garousi, Haozhong Ding, Emma von Witting, Tianqi Xu, Anzhelika Vorobyeva, Maryam Oroujeni, Anna Orlova, Sophia Hober, Torbjörn Gräslund, Vladimir Tolmachev
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1847 (2021)
Albumin binding domain derived affinity proteins (ADAPTs) are a class of small and folded engineered scaffold proteins that holds great promise for targeting cancer tumors. Here, we have extended the in vivo half-life of an ADAPT, targeting the human
Externí odkaz:
https://doaj.org/article/63cc572ea3ff4bcab28ecc7f10b18676
Autor:
Javad Garousi, Ken G. Andersson, Johan H. Dam, Birgitte B. Olsen, Bogdan Mitran, Anna Orlova, Jos Buijs, Stefan Ståhl, John Löfblom, Helge Thisgaard, Vladimir Tolmachev
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The 111In-labelled DOTA-conjugated ZEGFR:2377 Affibody molec
Externí odkaz:
https://doaj.org/article/8a636f58f2cd44c59a45fa82c0cdd9f2
Autor:
Sophia Hober, Vladimir Tolmachev, Anna Orlova, Hadis Honarvar, Mattias Sandström, Jos Buijs, Mikael Åstrand, Johan Nilvebrant, Sarah Lindbo, Javad Garousi
Analytical RP-HPLC analysis of purified DOTA-C-(HE)3-ADAPT6 ; Mass spectrum of purified DOTA-C-(HE)3-ADAPT6 ; Overlay of circular dichroism spectra from 250-195 nm for DOTA-C-(HE)3-ADAPT6 before (blue) and after (red) heating from 20-90{degree sign}C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2c1f011fde126e002a8dad2a9a1dba
https://doi.org/10.1158/0008-5472.22406385
https://doi.org/10.1158/0008-5472.22406385
Autor:
Sophia Hober, Vladimir Tolmachev, Anna Orlova, Hadis Honarvar, Mattias Sandström, Jos Buijs, Mikael Åstrand, Johan Nilvebrant, Sarah Lindbo, Javad Garousi
Small engineered scaffold proteins have attracted attention as probes for radionuclide-based molecular imaging. One class of these imaging probes, termed ABD-Derived Affinity Proteins (ADAPT), has been created using the albumin-binding domain (ABD) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c118c7a1c9ffa9352b49f6017ecfc3
https://doi.org/10.1158/0008-5472.c.6507066
https://doi.org/10.1158/0008-5472.c.6507066
Autor:
Sophia Hober, Vladimir Tolmachev, Anna Orlova, Hadis Honarvar, Mattias Sandström, Jos Buijs, Mikael Åstrand, Johan Nilvebrant, Sarah Lindbo, Javad Garousi
Affinity constants of DOTA-C-(HE)3-ADAPT6 and H6-ADAPT6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f033af2e0728cf1d19e5313e142817
https://doi.org/10.1158/0008-5472.22406379
https://doi.org/10.1158/0008-5472.22406379