Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Jaume Piulats"'
1
Synthesis and biological evaluation of novel indolocarbazoles with anti-angiogenic activity
Autor: Francesc Mitjans, Nuria Acero, Loreto Añorbe, Jaume Piulats, Gema Domínguez, Miguel F. Brana, Dolores Muñoz-Mingarro
Publikováno v: European Journal of Medicinal Chemistry. 48:108-113
A novel series of indolocarbazoles were synthesized and their antiproliferative activity against HUVEC, LoVo, DLD-1 and ST-486 cell lines, was investigated. Those staurosporine analogs in which a substituted dimethylaminoalkoxy chain was attached to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df9f2e9ef36d27e7f118d2eb58d189a
https://doi.org/10.1016/j.ejmech.2011.11.040
Zobrazit plný text záznamu
2
Amide-to-Ester Substitution Allows Fine-Tuning of the Cyclopeptide Conformational Ensemble
Autor: Javier Ruiz-Rodríguez, Jaume Adan, Jaume Piulats, Fernando Albericio, Jan Spengler, Tommaso Cupido, Francesc Mitjans
Publikováno v: Angewandte Chemie. 122:2792-2797
Natural or designed peptide ligands rarely bind to cognate receptors in their most stable conformation when in solution. The receptor, through reciprocal induced fitting, applies pressure on the conformational ensemble of the peptide to select its co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467b786d60bb27ada3458880d66d4e87
https://doi.org/10.1002/ange.200907274
Zobrazit plný text záznamu
4
Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody
Autor: Gemma Coma, Francesc Mitjans, Bonaventura Clotet, Margarita Bofill, José A. Esté, Berta Bosch, Jaume Piulats, Eduardo Pauls, Samandhy Cedeño, Anuska Llano, Julià Blanco, Imma Clotet-Codina
Publikováno v: Antiviral Research. 69:173-180
Macrophages are key cells for HIV infection and HIV spreading inside the organism. Macrophages cultured in vitro can be successfully infected after differentiation with cytokines such as macrophage colony stimulating factor (M-CSF). In the monocyte t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647d05012cf3bdcc28a163552ea25115
https://doi.org/10.1016/j.antiviral.2005.12.004
Zobrazit plný text záznamu
5
Anti-migratory and anti-angiogenic effect of p16: A novel localization at membrane ruffles and lamellipodia in endothelial cells
Autor: Mercè Rodríguez, Francesc Mitjans, Elena Alhaja, Jaume Piulats, Carlos J. Ciudad, Véronique Noé, Roser Pagan, Senén Vilaró, Adela Mazo, Jaume Adan, Manel Cascallo
Publikováno v: Angiogenesis. 7:323-333
Recent evidence has established different functions for the tumor suppressor protein, p16(INK4A) aside from controlling the cell cycle. Here we report that cdk4/6 inhibition blocked both human umbilical vein endothelial cells (HUVEC) spreading on a v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a19f8960f902254813fa69a014e6a8e
https://doi.org/10.1007/s10456-005-0368-9
Zobrazit plný text záznamu
6
Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro
Autor: Simon L. Goodman, G. Klöppel, Jaume Piulats, Bence Sipos, D Hahn, Ana Carceller, Holger Kalthoff, Markus Kosmahl, J Hedderich
Publikováno v: Histopathology. 45:226-236
Aims To analyse the expression of alphavbeta6, an epithelial integrin involved in wound healing and tumorigenesis, in various human carcinoma types. Methods and results A new monoclonal antibody to the human beta6 subunit, 5C4, was used to locate alp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83948e3a8d730d52eddd9999a108604b
https://doi.org/10.1111/j.1365-2559.2004.01919.x
Zobrazit plný text záznamu
7
Expression Profiles of a Human Pancreatic Cancer Cell Line upon Induction of Apoptosis Search for Modulators in Cancer Therapy
Autor: Francesc Blasco, Marta Nicolás, Adela Mazo, Cristina Alemany, Manel Cascallo, Marc Masa, José L. Hernández, Jaume Piulats, Carlos J. Ciudad, M. Soler, G. Tarrasón, Véronique Noé, Silvia Peñuelas, Joaquim Calbó, A. Gómez, Sandra Pérez-Torras
Publikováno v: Oncology. 67:277-290
We analyzed the differential gene expression in the pancreatic cancer cell line NP-18 upon induction of apoptosis caused by cyclin-dependent kinase inhibition triggered by either overexpression of the tumor suppressor gene p16INK4Ausing an adenoviral
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f384dd3d12ca11c548a6d314f2a53b
https://doi.org/10.1159/000081329
Zobrazit plný text záznamu
8
E2F transcription factors and cancer
Autor: Gema Tarrasón, Jaume Piulats
Publikováno v: Revista de Oncología. 3:241-249
Tumor cells have developed successful mechanisms to escape the normal controls that regulate cell proliferation and apoptosis. Basic research can help in the processes of target discovery for designing new therapeutic interventions in oncology based
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e15190644b0bf396630b609ee68b592
https://doi.org/10.1007/bf02719883
Zobrazit plný text záznamu
10
In vivo therapy of malignant melanoma by means of antagonists of αv integrins
Autor: Germán Reyes, Alfred Jonczyk, Jaume Piulats, Simon L. Goodman, Claus Fittschen, John Marshall, Francesc Mitjans, Tim Meyer
Publikováno v: International Journal of Cancer. 87:716-723
Integrin alphavbeta3 (vitronectin receptor) has been implicated in human malignant melanoma progression and angiogenesis as a receptor that provides survival signals. However, little is known about the therapeutic potential of antagonists of alphavbe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b21ef576506a44dea2248306925bb5f8
https://doi.org/10.1002/1097-0215(20000901)87:5<716::aid-ijc14>3.0.co
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje