Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jaume Lillo"'
Publikováno v:
Cells, Vol 13, Iss 15, p 1288 (2024)
The first objective is to highlight the lack of tools to measure whether a given intervention affords neuroprotection in patients with Alzheimer’s or Parkinson’s diseases. A second aim is to present the primary outcome measures used in clinical t
Externí odkaz:
https://doaj.org/article/cc4ed848393c490d82033134cc5b1005
Autor:
Iu Raïch, Jaume Lillo, Rafael Rivas-Santisteban, Joan Biel Rebassa, Toni Capó, Montserrat Santandreu, Erik Cubeles-Juberias, Irene Reyes-Resina, Gemma Navarro
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6708 (2024)
Stroke is one of the leading causes of death. It not only affects adult people but also many children. It is estimated that, every year, 15 million people suffer a stroke worldwide. Among them, 5 million people die, while 5 million people are left pe
Externí odkaz:
https://doaj.org/article/63ddcb036fcd4b96bd1f6da55bc7ca38
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5378 (2024)
Alzheimer’s disease (AD) remains a significant health challenge, with an increasing prevalence globally. Recent research has aimed to deepen the understanding of the disease pathophysiology and to find potential therapeutic interventions. In this r
Externí odkaz:
https://doaj.org/article/16886b80b4c2435799d0cfb1f5c4b396
Autor:
Iu Raïch, Jaume Lillo, Joan Biel Rebassa, Toni Capó, Arnau Cordomí, Irene Reyes-Resina, Mercè Pallàs, Gemma Navarro
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4757 (2024)
Alzheimer’s disease (AD) is the main cause of dementia worldwide. Given that learning and memory are impaired in this pathology, NMDA receptors (NMDARs) appear as key players in the onset and progression of the disease. NMDARs are glutamate recepto
Externí odkaz:
https://doaj.org/article/08eb59e630e44e9b85cb7c1d824047b1
Publikováno v:
Cells, Vol 13, Iss 7, p 615 (2024)
Alterations in olfactory functions are proposed as possible early biomarkers of neurodegenerative diseases. Parkinson’s and Alzheimer’s diseases manifest olfactory dysfunction as a symptom, which is worth mentioning. The alterations do not occur
Externí odkaz:
https://doaj.org/article/c4e242d2faa644bea5928c89c89bbeb6
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 3021 (2024)
One of the hallmarks of Parkinson’s disease (PD) is the alteration in the expression and function of NMDA receptor (NMDAR) and cannabinoid receptor 1 (CB1R). The presence of CB1R-NMDAR complexes has been described in neuronal primary cultures. The
Externí odkaz:
https://doaj.org/article/a2f9a35e87a2407699bb48e97f2aab23
Autor:
Jaume Lillo, Irene García-Pérez, Alejandro Lillo, Joan Serrano-Marín, Eva Martínez-Pinilla, Gemma Navarro, Rafael Franco
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Heteromer formation is unknown for the olfactory family of G protein-coupled receptors (GPCRs). We here identified, in a heterologous system, heteromers formed by the adenosine A2A receptor (A2AR), which is a target for neuroprotection, and an olfact
Externí odkaz:
https://doaj.org/article/97de8941c7574105bca05a609f938cc7
Autor:
Iu Raïch, Jaume Lillo, Carlos Ferreiro-Vera, Verónica Sánchez de Medina, Gemma Navarro, Rafael Franco
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17500 (2023)
Cannabidiol (CBD) is a phytocannabinoid with potential as a therapy for a variety of diseases. CBD may act via cannabinoid receptors but also via other G-protein-coupled receptors (GPCRs), including the adenosine A2A receptor. Homogenous binding and
Externí odkaz:
https://doaj.org/article/865254b0964746159cc8444744afcf27
Publikováno v:
Cells, Vol 12, Iss 18, p 2213 (2023)
Microglial activation often accompanies the plastic changes occurring in the brain of patients with neurodegenerative diseases. A2A and A3 adenosine receptors have been proposed as therapeutic targets to combat neurodegeneration. RNAseq was performed
Externí odkaz:
https://doaj.org/article/f1c7bcee2d05449a8fe89ae1de79bdc5
Autor:
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neuro
Externí odkaz:
https://doaj.org/article/0254e2d26c33408e83ebdd64aef88946