Výsledky vyhledávání - "Jaume, Aguero"

Akademický článek

Increased Afterload Following MyocardialÂ Infarction Promotes Conduction-Dependent Arrhythmias ThatÂ Are Unmasked by Hypokalemia

Autor: Lukas J. Motloch, MD, PhD, Kiyotake Ishikawa, MD, Chaoqin Xie, MD, Jun Hu, PhD, Jaume Aguero, MD, Kenneth M. Fish, PhD, Roger J. Hajjar, MD, Fadi G. Akar, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 3, Pp 258-269 (2017)

Summary: Although the pathophysiological significance of resistant hypertension in postâmyocardial infarction (MI) patients is established, the mechanisms by which increased afterload in that setting worsens outcome are unclear. With regard to sudde

Externí odkaz: https://doaj.org/article/567e3ad87774479d87bf53f3def6720d

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Akademický článek

Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension

Autor: Shin Watanabe, Kiyotake Ishikawa, Maria Plataki, Olympia Bikou, Erik Kohlbrenner, Jaume Aguero, Lahouaria Hadri, Iratxe Zarragoikoetxea, Kenneth Fish, Jane A. Leopold, Roger J. Hajjar

Publikováno v: Pulmonary Circulation, Vol 8 (2018)

Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca 2+ -ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a re

Externí odkaz: https://doaj.org/article/66d448932dd94386bd31bedc7c4bb649

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Akademický článek

Primary Effect of SERCA2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction

Autor: Lukas J. Motloch, Marine Cacheux, Kiyotake Ishikawa, Chaoqin Xie, Jun Hu, Jaume Aguero, Kenneth M. Fish, Roger J. Hajjar, Fadi G. Akar

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 18 (2018)

Background SERCA2a gene transfer (GT) improves mechano‐electrical function in animal models of nonischemic heart failure Whether SERCA2a GT reverses pre‐established remodeling at an advanced stage of ischemic heart failure is unclear. We sought t

Externí odkaz: https://doaj.org/article/35cb35932287459a889787e0ed9d9a8b

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Akademický článek

Left Ventricular Unloading Using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure

Autor: Shin Watanabe, Kenneth Fish, Jason C. Kovacic, Olympia Bikou, Lauren Leonardson, Koichi Nomoto, Jaume Aguero, Navin K. Kapur, Roger J. Hajjar, Kiyotake Ishikawa

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 6 (2018)

BackgroundDelivering therapeutic materials, like stem cells or gene vectors, to the myocardium is difficult in the setting of ischemic heart failure because of decreased coronary flow and impaired microvascular perfusion (MP). The aim of this study w

Externí odkaz: https://doaj.org/article/c2697b7d7bbd4facbd9610e54b9464fa

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Incidence and Risk Factors for Development of Cardiac Toxicity in Adult Patients with Newly Diagnosed Acute Myeloid Leukemia

Publikováno v: Cancers; Volume 15; Issue 8; Pages: 2267

The incidence of cardiac morbimortality in acute myeloid leukemia (AML) is not well known. We aim to estimate the cumulative incidence (CI) of cardiac events in AML patients and to identify risk factors for their occurrence. Among 571 newly diagnosed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259d8250aa0ea19b5eed9c591d5dab5a
https://doi.org/10.3390/cancers15082267

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Endobronchial Aerosolized AAV1.SERCA2a Gene Therapy in a Pulmonary Hypertension Pig Model: Addressing the Lung Delivery Bottleneck

Autor: Olympia Bikou, Serena Tharakan, Kelly P. Yamada, Taro Kariya, Jaume Aguero, Alexandra Gordon, Renata Mazurek, Tadao Aikawa, Erik Kohlbrenner, Kenneth M. Fish, Roger J. Hajjar, Kiyotake Ishikawa

Publikováno v: Hum Gene Ther

A disappointing number of new therapies for pulmonary hypertension (PH) have been successfully translated to the clinic. Adeno-associated viral (AAV) gene therapy has the potential to treat the underlying pathology of PH, but the challenge remains in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff2f21f480bba1ae09cbaa28f6a738
https://europepmc.org/articles/PMC9142769/

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Akademický článek

Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction

Autor: Kiyotake Ishikawa, Jaume Aguero, Jae Gyun Oh, Nadjib Hammoudi, Lauren A. Fish, Lauren Leonardson, Belén Picatoste, Carlos G. Santos‐Gallego, Kenneth M. Fish, Roger J. Hajjar

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 4, Iss 5, Pp n/a-n/a (2015)

Background It remains unclear whether abnormal systolic function and relaxation are essential for developing heart failure in pathophysiology of severe aortic stenosis. Methods and Results Yorkshire pigs underwent surgical banding of the ascending ao

Externí odkaz: https://doaj.org/article/2ef996fdb3d04ea6b3c9a60bf212ae01

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Akademický článek

Combination proximal pulmonary artery coiling and distal embolization induces chronic elevations in pulmonary artery pressure in Swine.

Autor: Jaume Aguero, Kiyotake Ishikawa, Kenneth M Fish, Nadjib Hammoudi, Lahouaria Hadri, Ana Garcia-Alvarez, Borja Ibanez, Valentin Fuster, Roger J Hajjar, Jane A Leopold

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124526 (2015)

Pulmonary hypertension (PH) is associated with aberrant vascular remodeling and right ventricular (RV) dysfunction that contribute to early mortality. Large animal models that recapitulate human PH are essential for mechanistic studies and evaluating

Externí odkaz: https://doaj.org/article/c0f794946ac34527a62e5b1dbfe7431e

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