Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Jau-Nian Chen"'
Autor:
Adam D. Langenbacher, Fei Lu, Lauren Crisman, Zi Yi Stephanie Huang, Douglas J. Chapski, Thomas M. Vondriska, Yibin Wang, Chen Gao, Jau-Nian Chen
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 5, p 221 (2023)
The PAF1 complex component Rtf1 is an RNA Polymerase II-interacting transcription regulatory protein that promotes transcription elongation and the co-transcriptional monoubiquitination of histone 2B. Rtf1 plays an essential role in the specification
Externí odkaz:
https://doaj.org/article/2247b419ebec41f88a84da7d1beec553
Autor:
Hirohito Shimizu, Simon Huber, Adam D. Langenbacher, Lauren Crisman, Jie Huang, Kevin Wang, Fabiola Wilting, Thomas Gudermann, Johann Schredelseker, Jau-Nian Chen
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, includ
Externí odkaz:
https://doaj.org/article/f1a4486601394aacbc108e43e8005254
Autor:
Adam D. Langenbacher, Hirohito Shimizu, Welkin Hsu, Yali Zhao, Alexandria Borges, Carla Koehler, Jau-Nian Chen
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mitochondrial Ca2 + uptake influences energy production, cell survival, and Ca2 + signaling. The mitochondrial calcium uniporter, MCU, is the primary route for uptake of Ca2 + into the mitochondrial matrix. We have generated a zebrafish MCU mutant th
Externí odkaz:
https://doaj.org/article/909179c5e8a641d4bd9e38f2978d8e47
Autor:
Safiyyah Ziyad, Jesse D. Riordan, Ann M. Cavanaugh, Trent Su, Gloria E. Hernandez, Georg Hilfenhaus, Marco Morselli, Kristine Huynh, Kevin Wang, Jau-Nian Chen, Adam J. Dupuy, M. Luisa Iruela-Arispe
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1211-1224 (2018)
Summary: Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies. Here, we find that endothelium-specific
Externí odkaz:
https://doaj.org/article/a74c22f7c9d148fc88f5c03dbb005087
Autor:
Hirohito Shimizu, Adam D Langenbacher, Jie Huang, Kevin Wang, Georg Otto, Robert Geisler, Yibin Wang, Jau-Nian Chen
Publikováno v:
eLife, Vol 6 (2017)
Altered Ca2+ handling is often present in diseased hearts undergoing structural remodeling and functional deterioration. However, whether Ca2+ directly regulates sarcomere structure has remained elusive. Using a zebrafish ncx1 mutant, we explored the
Externí odkaz:
https://doaj.org/article/efe360faa79f481eb6f76f71d47df7de
Autor:
Hirohito Shimizu, Johann Schredelseker, Jie Huang, Kui Lu, Shamim Naghdi, Fei Lu, Sarah Franklin, Hannah DG Fiji, Kevin Wang, Huanqi Zhu, Cheng Tian, Billy Lin, Haruko Nakano, Amy Ehrlich, Junichi Nakai, Adam Z Stieg, James K Gimzewski, Atsushi Nakano, Joshua I Goldhaber, Thomas M Vondriska, György Hajnóczky, Ohyun Kwon, Jau-Nian Chen
Publikováno v:
eLife, Vol 4 (2015)
Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca2+ handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca2+ extrusion de
Externí odkaz:
https://doaj.org/article/2f19b0f5e68e46e088b8efd2e64e693f
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 3, Iss 2, p 14 (2016)
Cardiac transcription factors orchestrate the complex cellular and molecular events required to produce a functioning heart. Misregulation of the cardiac transcription program leads to embryonic developmental defects and is associated with human cong
Externí odkaz:
https://doaj.org/article/e4b9b11e26fc4f1cb7a8b4569c7abe92
Autor:
Kevin Mouillesseaux, Jau-Nian Chen
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25013 (2011)
Angiogenesis is the process by which the highly branched and functional vasculature arises from the major vessels, providing developing tissues with nutrients, oxygen, and removing metabolic waste. During embryogenesis, vascular patterning is depende
Externí odkaz:
https://doaj.org/article/d2254183c3314dae86b04c26089b615c
Autor:
M. Luisa Iruela-Arispe, Robert Damoiseaux, Jau-Nian Chen, Matteo Pellegrini, Young Ah Goo, Byoung-Kyu Cho, Dana Song, Snezana Mirkov, Adam D. Langenbacher, Feiyang Ma, Vanessa M. Freitas, Gloria Hernandez, Divya P. Prajapati, Jonathan Freshman, Ana Mompeón, Georg Hilfenhaus
Metastases largely rely on hematogenous dissemination of tumor cells via the vascular system and significantly limit prognosis of patients with solid tumors. To colonize distant sites, circulating tumor cells must destabilize the endothelial barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ae16b8fa594f02278f5673f0c895d3
https://doi.org/10.1158/0008-5472.c.6512095.v1
https://doi.org/10.1158/0008-5472.c.6512095.v1
Autor:
M. Luisa Iruela-Arispe, Robert Damoiseaux, Jau-Nian Chen, Matteo Pellegrini, Young Ah Goo, Byoung-Kyu Cho, Dana Song, Snezana Mirkov, Adam D. Langenbacher, Feiyang Ma, Vanessa M. Freitas, Gloria Hernandez, Divya P. Prajapati, Jonathan Freshman, Ana Mompeón, Georg Hilfenhaus
Effects of positive hits on endothelial barrier, cytoskeletal organization and tumor cell motility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190d4476850e1d003b1ac19bf240c2a9
https://doi.org/10.1158/0008-5472.22425637.v1
https://doi.org/10.1158/0008-5472.22425637.v1