Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jatzlau, P."'
Autor:
Vladimir Ugorets, Paul-Lennard Mendez, Dmitrii Zagrebin, Giulia Russo, Yannic Kerkhoff, Georgios Kotsaris, Jerome Jatzlau, Sigmar Stricker, Petra Knaus
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110630- (2024)
Summary: Controlled myogenic differentiation is integral to the development, maintenance and repair of skeletal muscle, necessitating precise regulation of myogenic progenitors and resident stem cells. The transformation of proliferative muscle proge
Externí odkaz:
https://doaj.org/article/e6878bb5d4dc4feca4d91dec25309444
Autor:
Juliana Reinhardt, Michaela Tischer, Simon Schmid, Jochen Kollofrath, Ruben Burger, Philipp Jatzlau, Elisabeth Bushart, Matthias Goldammer, Christian U. Grosse
Publikováno v:
Heritage Science, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract What are Cy Twombly’s sculptures made of? This article presents an overview of a non-destructive examination conducted on three sculptures by American artist Cy Twombly (1928–2011) as part of an art-technological research project at the
Externí odkaz:
https://doaj.org/article/957779d3f7ae49d39e3b1bb3ff28f876
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102859- (2024)
Summary: Chromatin accessibility influences gene regulation and can be quantified using assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq). Recapitulating in vivo fluid shear stress (FSS) mechano-regimes in vitro al
Externí odkaz:
https://doaj.org/article/1058e14ac710475589f453c56254689d
Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Autor:
Uirá Souto Melo, Jerome Jatzlau, Cesar A. Prada-Medina, Elisabetta Flex, Sunhild Hartmann, Salaheddine Ali, Robert Schöpflin, Laura Bernardini, Andrea Ciolfi, M-Hossein Moeinzadeh, Marius-Konstantin Klever, Aybuge Altay, Pedro Vallecillo-García, Giovanna Carpentieri, Massimo Delledonne, Melanie-Jasmin Ort, Marko Schwestka, Giovanni Battista Ferrero, Marco Tartaglia, Alfredo Brusco, Manfred Gossen, Dirk Strunk, Sven Geißler, Stefan Mundlos, Sigmar Stricker, Petra Knaus, Elisa Giorgio, Malte Spielmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players in driving ectopic bone formation. Identifying novel genes and pathways rel
Externí odkaz:
https://doaj.org/article/4848e7ed684e495f8ace27fcba8b8f77
Autor:
Ingrid Quist-Løkken, Clara Andersson-Rusch, Martin Haugrud Kastnes, Jürgen Markus Kolos, Jerome Jatzlau, Hanne Hella, Oddrun Elise Olsen, Anders Sundan, Petra Knaus, Felix Hausch, Toril Holien
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as t
Externí odkaz:
https://doaj.org/article/1d7144747e7f4e01a14dd611f82ff44b
Autor:
Jerome Jatzlau, Wiktor Burdzinski, Michael Trumpp, Leon Obendorf, Kilian Roßmann, Katharina Ravn, Marko Hyvönen, Francesca Bottanelli, Johannes Broichhagen, Petra Knaus
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
A TGFβ/BMP receptor library with Halo- and SNAP-tags is generated and with the application of labeled growth factor ligands, a ligand surface binding assay is developed, allowing assessment of preferential ligand-receptor binding in cells.
Externí odkaz:
https://doaj.org/article/ecd9aa0c06c24813a2ac0f64c9f2cd06
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jerome Jatzlau, Paul-Lennard Mendez, Aybuge Altay, Lion Raaz, Yufei Zhang, Sophia Mähr, Akin Sesver, Maria Reichenbach, Stefan Mundlos, Martin Vingron, Petra Knaus
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107405- (2023)
Summary: Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and FSS
Externí odkaz:
https://doaj.org/article/d3aa69edba6440b8ab59fccf51ddb428
Autor:
Paul-Lennard Mendez, Leon Obendorf, Jerome Jatzlau, Wiktor Burdzinski, Maria Reichenbach, Vanasa Nageswaran, Arash Haghikia, Verena Stangl, Christian Hiepen, Petra Knaus
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial quiescence, excessive
Externí odkaz:
https://doaj.org/article/f21e33dc96904caabcbae15c6de679ca
Autor:
Szabina Szófia Szilágyi, Wiktor Burdzinski, Jerome Jatzlau, Marcelo Ehrlich, Petra Knaus, Yoav I. Henis
Publikováno v:
Cells, Vol 13, Iss 3, p 221 (2024)
Mutations in activin-like kinase 2 (ALK2), e.g., ALK2-R206H, induce aberrant signaling to SMAD1/5/8, leading to Fibrodysplasia Ossificans Progressiva (FOP). In spite of extensive studies, the underlying mechanism is still unclear. Here, we quantified
Externí odkaz:
https://doaj.org/article/2470728418d1447e991046b9de50c9d8