Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jatinder S Josan"'
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp n/a-n/a (2016)
Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants
Externí odkaz:
https://doaj.org/article/cf1c1a8640554626b04f8b7d235ebf06
Publikováno v:
eLife, Vol 2 (2013)
By using in silico models of the complexes formed by analogues of a cancer drug and its receptor, it may be possible to strategically redesign existing drugs and win the race against mutations that lead to drug resistance in prostate cancer.
Externí odkaz:
https://doaj.org/article/2eb58a7ead8e4f09960addaa0434ed9d
Publikováno v:
Journal of Chromatography B. 1092:279-285
The enantiomeric separation of a racemate of 7-oxa-bicyclo[2.2.1]heptene sulfonate (OBHS) derivatives, a Selective Estrogen Receptor Modulator (SERM), was obtained using supercritical fluid chromatography in tandem with UV and mass spectrometry (SFC/
Autor:
Jatinder S. Josan, Sathish Srinivasan, Kendall W. Nettles, K Pokludova, John A. Katzenellenbogen, S Devi
Publikováno v:
Cancer Research. 77:P2-08
This abstract was not presented at the symposium.
Autor:
John D. Norris, Benita S. Katzenellenbogen, Jessica L. Christenson, Jatinder S. Josan, Kiel T. Butterfield, Donald P. McDonnell, Nicole S. Spoelstra, John A. Katzenellenbogen, Julie A. Pollock, Jennifer K. Richer
Publikováno v:
Hormones and Cancer. 8:69-77
Triple-negative breast cancer (TNBC) has a faster rate of metastasis compared to other breast cancer subtypes, and no effective targeted therapies are currently FDA-approved. Recent data indicate that the androgen receptor (AR) promotes tumor surviva
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1647
In vitro cytotoxicity tests allow for fast and inexpensive screening of drug efficacy prior to in vivo studies. The resazurin assay (commercialized as Alamar Blue
Publikováno v:
Methods in Molecular Biology ISBN: 9781493972005
In vitro cytotoxicity tests allow for fast and inexpensive screening of drug efficacy prior to in vivo studies. The resazurin assay (commercialized as Alamar Blue®) has been extensively utilized for this purpose in 2D and 3D cell cultures, and high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e45f0afcdddf8a44a375949e3002a916
https://doi.org/10.1007/978-1-4939-7201-2_14
https://doi.org/10.1007/978-1-4939-7201-2_14
Autor:
Jatinder S. Josan, Robert J. Gillies, Josef Vagner, Michael R. Caplan, Eugene A. Mash, David L. Morse, Ronald M. Lynch, Victor J. Hruby, Liping Xu
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21295-21300
A challenge in tumor targeting is to deliver payloads to cancers while sparing normal tissues. A limited number of antibodies appear to meet this challenge as therapeutics themselves or as drug-antibody conjugates. However, antibodies suffer from the
Autor:
Nicholas J. Wright, Jatinder S. Josan, René Houtman, Olivier Elemento, Jerome C. Nwachukwu, Chune Dong, Hai-Bing Zhou, Yangfan Zheng, Jian Min, Sathish Srinivasan, Kendall W. Nettles, John A. Katzenellenbogen, Song Wang, Jason Nowak, Kathryn E. Carlson, Zongquan Liao
Publikováno v:
Molecular Systems Biology
Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants of cell
Autor:
Valerie E. Stark, David L. Morse, Jongphil Kim, Jatinder S. Josan, Mark C. Lloyd, Victor J. Hruby, Allison S. Cohen, Amanda Shanks Huynh, Joseph O. Johnson, Josef Vagner, Tingan Chen, Todd J. Casagni, Veronica Estrella
Publikováno v:
Molecular pharmaceutics. 13(2)
Fluorescence molecular imaging can be employed for the development of novel cancer targeting agents. Herein, we investigated the pharmacokinetics (PK), biodistribution (BD) and cellular uptake of Dmt-Tic-Cy5, a delta-opioid receptor (δOR) antagonist