Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Jatin R Verma"'
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Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models
Autor: James A. Tonkin, Ume-Kulsoom Shah, Shareen H. Doak, M. R. Brown, Katherine E. Chapman, George E. Johnson, Eleanor C. Wilde, Gareth J.S. Jenkins, Jatin R Verma
Publikováno v: Mutagenesis. 35:445-452
In vitro genotoxicity studies are a quick and high throughput approach to assess the genotoxic potential of chemicals; however, the reliability of these tests and their relevance to in vivo effects depends on the choice of representative cell line an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b755356f16ce5a2d98c3ba5d94c14241
https://doi.org/10.1093/mutage/geaa029
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5
A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells
Autor: George E. Johnson, Katherine E. Chapman, Katja Brüsehafer, Gareth J.S. Jenkins, M. Rowan Brown, Jatin R. Verma, Ume-Kulsoom Shah, Leanne M. Stannard, Eleanor C. Wilde, Shareen H. Doak, Anna L. Seager, James A. Tonkin, Ann T. Doherty
Publikováno v: Archives of Toxicology
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70–90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation. Both cu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d5058ecc28a1ac7797ee5faa9135b
https://doi.org/10.1007/s00204-017-2102-y
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6
Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro
Autor: Gareth J.S. Jenkins, Catherine A. Thornton, U. K. Shah, Danielle S.G. Harte, John W. Wills, Jatin R. Verma, Shareen H. Doak, Paul Rees, George E. Johnson, Huw D. Summers
Publikováno v: Mutagenesis. 33(4)
Use of imaging flow cytometry to assess induced DNA damage via the cytokinesis block micronucleus (CBMN) assay has thus far been limited to radiation dosimetry in human lymphocytes using high end, 'ImageStream X' series imaging cytometers. Its potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ba3a02b5bf859ee05f4149690f476a
https://pubmed.ncbi.nlm.nih.gov/30204902
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7
New approaches to advance the use of genetic toxicology analyses for human health risk assessment
Autor: George E. Johnson, B. Bhaskar Gollapudi, Ben J. Rees, Gareth J.S. Jenkins, Mick D. Fellows, Shareen H. Doak, Lya G. Soeteman-Hernández, Jatin R. Verma, Robert H. Heflich, Paul D. White, Wout Slob, John W. Wills
Publikováno v: Toxicology Research. 4:667-676
Genetic toxicology testing has a crucial role in the safety assessment of new and existing substances of societal value by reducing/eliminating human exposure to potential somatic and germ cell mutagens. Genetic toxicology assays have historically be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5263a0520e9519dfa4d10aec0c16a4
https://doi.org/10.1039/c4tx00118d
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10
Evaluation of the automated MicroFlow
Autor: Jatin R, Verma, Benjamin J, Rees, Eleanor C, Wilde, Catherine A, Thornton, Gareth J S, Jenkins, Shareen H, Doak, George E, Johnson
Publikováno v: Archives of Toxicology
The use of manual microscopy for the scoring of chromosome damage in the in vitro micronucleus assay is often associated with user subjectivity. This level of subjectivity can be reduced by using automated platforms, which have added value of faster
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc3e258af0572a426fbb75540bfba360
https://pubmed.ncbi.nlm.nih.gov/27942789
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