Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jatin K. Nagpal"'
Autor:
David Sidransky, Barry Trink, Stephen P. Ethier, Kari I. Kivirikko, Joni M. Maki, Junwei Liu, Jatin K. Nagpal, Myoung Sook Kim, Xiaofei Chang, Zhongmin Guo, Guojun Wu
Supplementary Data 1 from LOXL1 and LOXL4 Are Epigenetically Silenced and Can Inhibit Ras/Extracellular Signal-Regulated Kinase Signaling Pathway in Human Bladder Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273f0e2f20ba341d3444b9fe8596edd7
https://doi.org/10.1158/0008-5472.22370414
https://doi.org/10.1158/0008-5472.22370414
Autor:
David Sidransky, Barry Trink, Stephen P. Ethier, Kari I. Kivirikko, Joni M. Maki, Junwei Liu, Jatin K. Nagpal, Myoung Sook Kim, Xiaofei Chang, Zhongmin Guo, Guojun Wu
Promoter hypermethylation is one of the common mechanisms leading to gene silencing in various human cancers. Using a combination of pharmacologic unmasking and microarray techniques, we identified 59 candidate hypermethylated genes, including LOXL1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7610b50b1a6eace10daeb751667716c3
https://doi.org/10.1158/0008-5472.c.6496391
https://doi.org/10.1158/0008-5472.c.6496391
Autor:
Mariana Brait, Shizhang Ling, Jatin K Nagpal, Xiaofei Chang, Hannah Lui Park, Juna Lee, Jun Okamura, Keishi Yamashita, David Sidransky, Myoung Sook Kim
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44951 (2012)
The human cysteine dioxygenase 1 (CDO1) gene is a non-heme structured, iron-containing metalloenzyme involved in the conversion of cysteine to cysteine sulfinate, and plays a key role in taurine biosynthesis. In our search for novel methylated gene p
Externí odkaz:
https://doaj.org/article/8c28aefba61040f0ab9eaee9d917bc09
Autor:
Myoung Sook Kim, Xiaofei Chang, Cynthia LeBron, Jatin K Nagpal, Juna Lee, Yiping Huang, Keishi Yamashita, Barry Trink, Edward A Ratovitski, David Sidransky
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9003 (2010)
Aerobic glycolysis and mitochondrial dysfunction are common features of aggressive cancer growth. We observed promoter methylation and loss of expression in neurofilament heavy polypeptide (NEFH) in a significant proportion of primary esophageal squa
Externí odkaz:
https://doaj.org/article/17717551b1614ea7be08ae7c2db937a0
Autor:
Jatin K. Nagpal, Enamul Haque, Anamika Bose, Chinmay Kumar Panda, Rathindranath Baral, Bhagawan Mishra, Bibhu Ranjan Das, Smarajit Pal, Sonali Paul, Chinmoyee Ray, Debolina Pal
Publikováno v:
Experimental and Molecular Pathology. 87:36-41
Expression of STAT3/pSTAT3 in colorectal cancer (CRC) patients of Indian origin was studied to assess its significance in early detection and apoptosis regulation. Colorectal tissues with malignant lesions were STAT3/pSTAT3 positive in 66% of the cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8358dd65c71a1a41d33fc37e0c32ed5
https://doi.org/10.1016/j.yexmp.2009.03.002
https://doi.org/10.1016/j.yexmp.2009.03.002
Publikováno v:
Journal of Epithelial Biology & Pharmacology. 2:14-22
We previously found that the protein subunits of GPI-transamidase complex (e.g. PIG-U, PIG-T and GPAA1) play critical roles of oncogenes in human bladder and breast cancers manifesting their activities through signaling mecha- nisms that involve urok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cfa39776e9a1ac6729930b83daf0065
https://doi.org/10.2174/1875044300902010014
https://doi.org/10.2174/1875044300902010014
Autor:
David Sidransky, Barry Trink, Sunil Upadhyay, Tanusree Sen, Jatin K. Nagpal, Edward A. Ratovitski, Yiping Huang
Publikováno v:
Cell Cycle. 7:2846-2855
We previously found that the pro-apoptotic DNA damaging agent, cisplatin, mediated the proteasome-dependent degradation of Delta Np63 alpha associated with its increased phosphorylated status. Since Delta Np63 alpha usually plays an opposite role to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4aa1f04e4685e793b45b8ba05aff43
https://doi.org/10.4161/cc.7.18.6627
https://doi.org/10.4161/cc.7.18.6627
Autor:
Ratna K. Vadlamudi, Jatin K. Nagpal, Rajeshwar Rao Tekmal, Darrell W. Brann, Saikumar Pothana, Rajib Rajhans, Dimple Chakravarty, Sujit S. Nair
Publikováno v:
Molecular Cancer Research. 6:851-861
PELP1 (proline-rich, glutamic acid–rich, and leucine-rich protein-1) is a potential proto-oncogene that functions as a coregulator of estrogen receptor (ER), and its expression is deregulated during breast cancer progression. Emerging evidence sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0239aab2df30f58e321d2c614f9919f1
https://doi.org/10.1158/1541-7786.mcr-07-2030
https://doi.org/10.1158/1541-7786.mcr-07-2030
Autor:
Yiping Huang, Joseph A. Califano, Edward A. Ratovitski, Barry Trink, Keishi Yamashita, Xiaofei Chang, Myoung Sook Kim, Cinthia Lebron, David Sidransky, Young Kwang Chae, Tony C. Y. Chuang, Jatin K. Nagpal
Publikováno v:
Biochemical and Biophysical Research Communications. 370:38-43
The pathogenesis of breast cancer involves multiple genetic and epigenetic events. In this study, we report an epigenetic alteration of DFNA5 in human breast cancer. DFNA5 gene was silenced in breast cancer cell lines that were methylated in the DFNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de35243efe2f6ee9db1a3c208464a77
https://doi.org/10.1016/j.bbrc.2008.03.026
https://doi.org/10.1016/j.bbrc.2008.03.026
Autor:
Rui Henrique, Kimberly Laskie Ostrow, Vim van Criekinge, Chu-So Moon, Guojun Wu, Ji Eun Lee, Carmen Jerónimo, Jatin K. Nagpal, Myoung Sook Kim, Junwei Liu, Barry Trink, David Sidransky, Keishi Yamashita
Publikováno v:
The Prostate. 68:418-426
BACKGROUND DNA methylation has emerged as a promising biomarker for prostate cancer detection. In this report, we screened 36 candidate genes generated by a bioinformatic analysis of the human genome, and found that the melanoma cell adhesion molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb34aa7d06254417a090cae24c4e453
https://doi.org/10.1002/pros.20709
https://doi.org/10.1002/pros.20709