Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jasveen Chugh"'
Autor:
Mariann Bienz, Kristian Birchall, Thomas C. Miller, Jasveen Chugh, Trevor J. Rutherford, Marc Fiedler
Publikováno v:
ACS Chemical Biology
The Pygo-BCL9 complex is a chromatin reader, facilitating β-catenin-mediated oncogenesis, and is thus emerging as a potential therapeutic target for cancer. Its function relies on two ligand-binding surfaces of Pygo’s PHD finger that anchor the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2033ea8747555fa67868dd60b2dd1a
https://doi.org/10.1021/cb500585s
https://doi.org/10.1021/cb500585s
Autor:
Roger S. Buxton, Barbara Saxty, Jasveen Chugh, Nathalie Bouloc, Simon A. Osborne, David Whalley, Stephen J. Smerdon, Kathryn E.A. Lougheed, Debra L. Taylor, Timothy M. Chapman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
A high-throughput screen against PknB, an essential serine–threonine protein kinase present in Mycobacterium tuberculosis (M. tuberculosis), allowed the identification of an aminoquinazoline inhibitor which was used as a sta
A high-throughput screen against PknB, an essential serine–threonine protein kinase present in Mycobacterium tuberculosis (M. tuberculosis), allowed the identification of an aminoquinazoline inhibitor which was used as a sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296dd119b1665181a18792ab111fb7b4
Autor:
Jasveen Chugh, David Whalley, Timothy J. Nott, Roger S. Buxton, Nathalie Bouloc, Barbara Saxty, Justin S. Bryans, Tim Chapman, Simon A. Osborne, Stephen J. Smerdon, Debra L. Taylor, Dony Patel, Vicky L. Spivey, Kathryn E.A. Lougheed, Catherine A. Kettleborough
Publikováno v:
Tuberculosis (Edinburgh, Scotland)
Summary PknB is an essential serine/threonine kinase of Mycobacterium tuberculosis with possible roles in a number of signalling pathways involved in cell division and metabolism. We screened a library of >50,000 compounds for inhibitors of the in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abdd92d44ab058e6319431f473742f5
http://europepmc.org/articles/PMC3158675
http://europepmc.org/articles/PMC3158675
Autor:
Ahmad Kamal, Jasveen Chugh, Michelle Newman, William Tsang, Debra L. Taylor, Edward G. McIver, Kristian Birchall, Philip Cohen, Alison Levy, Justin S. Bryans, Kristopher Clark, J. Simon C. Arthur, Joanne Osborne, Stephen John Lewis, Tom Drake, Ela Smiljanic-Hurley
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(23)
The design, synthesis and structure-activity relationships of a novel series of 2,4-diamino-5-cyclopropyl pyrimidines is described. Starting from BX795, originally reported to be a potent inhibitor of PDK1, we have developed compounds with improved s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03421520ece0a7d5ff12db79648b06e
https://pubmed.ncbi.nlm.nih.gov/23099093
https://pubmed.ncbi.nlm.nih.gov/23099093