Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE −/− Mice From Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

Autor: William M. Bailey, Jassir Witta, Preetha Shridas, Alan Daugherty, Victoria P. Noffsinger, Frederick C. de Beer, Anju Balakrishnan, Debra L. Rateri, Ailing Ji, Joanne M. Wroblewski, Richard Charnigo, Deborah A. Howatt, Nancy R. Webb, Maria C. de Beer

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1156-1165

Objective— Rupture of abdominal aortic aneurysm (AAA), a major cause of death in the aged population, is characterized by vascular inflammation and matrix degradation. Serum amyloid A (SAA), an acute-phase reactant linked to inflammation and matrix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6015e1976c8ab0a40958330747881f
https://doi.org/10.1161/atvbaha.114.304776

Corneal avascularity is due to soluble VEGF receptor-1

Autor: Tejvir S. Khurana, Angela Orecchia, Lucy J. Leiper, Jayakrishna Ambati, Sakae Ikeda, Hans-Peter Gerber, Masabumi Shibuya, Yuichiro Ogura, Donna Kwan, Balamurali K. Ambati, Atsunobu Takeda, Judit Z. Baffi, Megan Baldwin, Napoleone Ferrara, B.J. Raisler, Michael T. Newcomb, Qing Lin, P. Jani, Judy St. Leger, Jassir Witta, J. Martin Collinson, Elizabeth Richter, Mark E. Kleinman, Eiji Sakurai, Tushar Suthar, David T. Curiel, Sandro De Falco, Don Samuelson, W. Richard Green, Romulo Albuquerque, Nirbhai Singh, Helene Marsh, Sasha Bogdanovich, Parameshwar J. Mahasreshti, Dalen W. Agnew, Miho Nozaki, Ruth B. Caldwell

Publikováno v: Nature (Lond.) 443 (2006): 993–997. doi:10.1038/nature05249
info:cnr-pdr/source/autori:Ambati B.K.; Nozaki M.; Singh N.; Takeda A.; Jani P.D.; Suthar T.; Albuquerque R.J.; Richter E.; Sakurai E.; Newcomb M.T.; Kleinman M.E.; Caldwell R.B.; Lin Q.; Ogura Y.; Orecchia A.; Samuelson D.A.; Agnew D.W.; St Leger J.; Green W.R.; Mahasreshti P.J.; Curiel D.T.; Kwan D.; Marsh H.; Ikeda S.; Leiper L.J.; Collinson J.M.; Bogdanovich S.; Khurana T.S.; Shibuya M.; Baldwin M.E.; Ferrara N.; Gerber H.P.; De Falco S.; Witta J.; Baffi J.Z.; Raisler B.J.; Ambati J./titolo:Corneal avascularity is due to soluble VEGF receptor-1/doi:10.1038%2Fnature05249/rivista:Nature (Lond.)/anno:2006/pagina_da:993/pagina_a:997/intervallo_pagine:993–997/volume:443

Corneal avascularity—the absence of blood vessels in the cornea—is required for optical clarity and optimal vision, and has led to the cornea being widely used for validating pro- and anti-angiogenic therapeutic strategies for many disorders1-4.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5895895d2d9645d1d550255ce89560d5
https://doi.org/10.1038/nature05249

Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease

Autor: Brian M. Cox, Martina Fantin, Severo Salvadori, Flora Mela, Beata Buzas, Patrizia Romualdi, Rainer K. Reinscheid, Michele Morari, Michele Simonato, Sanzio Candeletti, Manuela Di Benedetto, Silvia Zucchini, Remo Guerrini, Jeffrey M. Brown, Jassir Witta, Matteo Marti

Publikováno v: The Journal of Neuroscience. 25:9591-9601

The opioid-like neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are expressed in the substantia nigra (SN), a brain area containing dopamine neurons that degenerate in Parkinson's disease. Endogenous N/OFQ facilitates nigral glutam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e637cb3faf7f4eb5056bed917f8ee5d
https://doi.org/10.1523/jneurosci.2546-05.2005

Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

Autor: Jassir Witta, Miklós Geiszt, Thomas L. Leto, Kristen Lekstrom

Publikováno v: Journal of Biological Chemistry. 278:20006-20012

Superoxide production by phagocytes involves activation of a multi-component NADPH oxidase. Recently, several homologues of the catalytic component of the phagocyte oxidase, gp91phox, were identified in various tissues. Here we describe two proteins,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d100bcbada2f732f71fb97736ba5ea25
https://doi.org/10.1074/jbc.m301289200

Abstract 64: Serum Amyloid A Augments Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in ApoE-Deficient Mice

Autor: Joanne M Wroblewski, Maria C De Beer, Jassir Witta, Debra L Rateri, Alan Daugherty, Frederick C De Beer, Nancy R Webb

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 32

Introduction and Objectives: Abdominal aortic aneurysm (AAA), a major cause of death in the aged population, is characterized by vascular inflammation and matrix degradation. Proteolytic enzymes, particularly matrix metalloproteinases (MMP’s), are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b13237cae8fdbe635c2e9e5b8bbcac2c
https://doi.org/10.1161/atvb.32.suppl_1.a64