Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jasreen Kular"'
Autor:
Pei Ying Ng, Amy B. P. Ribet, Qiang Guo, Benjamin H. Mullin, Jamie W. Y. Tan, Euphemie Landao-Bassonga, Sébastien Stephens, Kai Chen, Jinbo Yuan, Laila Abudulai, Maike Bollen, Edward T. T. T. Nguyen, Jasreen Kular, John M. Papadimitriou, Kent Søe, Rohan D. Teasdale, Jiake Xu, Robert G. Parton, Hiroshi Takayanagi, Nathan J. Pavlos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Despite the importance of osteoclast secretory lysosomes in bone digestion, the proteins that regulate them remain ill defined. Here, the authors identify Slc37a2 as a secretory lysosome sugar transporter that is required for maintenance of skeletal
Externí odkaz:
https://doaj.org/article/cfbfda3751ad47868d62c17e221301bd
Autor:
Brock Alan Le Cerf, Natasha Theresa Pyne, Jasreen Kular, Sarah Theresa Boyle, David Allan Beattie, Marta Krasowska, Michael Susithiran Samuel
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
While it is now well appreciated that the extracellular matrix (ECM) exerts biomechanical cues that direct critical cellular behavior, including cell proliferation, differentiation, migration, and survival, the molecular mechanisms underlying these c
Externí odkaz:
https://doaj.org/article/282fa1aeebea4e50aa61c0cd12efda15
Autor:
Pei Ying Ng, Amy B.P. Ribet, Qiang Guo, Benjamin H. Mullin, Jamie W.Y. Tan, Euphemie Landao-Bassonga, Sébastien Stephens, Kai Chen, Laila Abudulai, Maike Bollen, Edward T.T.T. Nguyen, Jasreen Kular, John M. Papadimitriou, Kent Søe, Rohan D. Teasdale, Jiake Xu, Robert G. Parton, Hiroshi Takanayagi, Nathan J. Pavlos
Osteoclasts are giant bone-digesting cells that harbour specialized lysosome-related organelles termed secretory lysosomes (SLs). SLs store cathepsin K and serve as a membrane precursor to the ruffled border, the osteoclast’s ‘resorptive apparatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6cceebe8381441963dab825ccedda9a
https://doi.org/10.1101/2022.04.28.489831
https://doi.org/10.1101/2022.04.28.489831
Autor:
Natasha T. Pyne, Marina Kochetkova, Andrew I. Webb, Alexander C. Lewis, Kendelle J. Murphy, Paul Timpson, Paul A.B. Moretti, Melinda N. Tea, Stuart M. Pitson, Angel F. Lopez, Sarah T. Boyle, Natasha Kolesnikoff, Vinay Tergaonkar, Jasreen Kular, Robert Whitfield, Jarrod J. Sandow, Valentina Poltavets, Michael S. Samuel
Publikováno v:
Nature Cell Biology. 22:882-895
It is well accepted that cancers co-opt the microenvironment for their growth. However, the molecular mechanisms that underlie cancer-microenvironment interactions are still poorly defined. Here, we show that Rho-associated kinase (ROCK) in the mamma
Autor:
Boyle, Sarah T., Jasreen Kular, Nobis, Max, Ruszkiewicz, Andrew, Timpson, Paul, Samuel, Michael S.
The ability to rapidly respond to applied force underpins cell/tissue homeostasis. This response is mediated by mechanotransduction pathways that regulate remodeling and tension of the actomyosin cytoskeleton to counterbalance external forces. Enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e45048ca1c1a004dd17d1ebedb8473
Autor:
Sarah Theresa, Boyle, Valentina, Poltavets, Jasreen, Kular, Natasha Theresa, Pyne, Jarrod John, Sandow, Alexander Charles, Lewis, Kendelle Joan, Murphy, Natasha, Kolesnikoff, Paul Andre Bartholomew, Moretti, Melinda Nay, Tea, Vinay, Tergaonkar, Paul, Timpson, Stuart Maxwell, Pitson, Andrew Ian, Webb, Robert John, Whitfield, Angel Francisco, Lopez, Marina, Kochetkova, Michael Susithiran, Samuel
Publikováno v:
Nature cell biology. 22(7)
It is well accepted that cancers co-opt the microenvironment for their growth. However, the molecular mechanisms that underlie cancer-microenvironment interactions are still poorly defined. Here, we show that Rho-associated kinase (ROCK) in the mamma
Autor:
Cassandra Stefanidis, Claudine S. Bonder, Briony L. Gliddon, Maurizio Costabile, Melinda N. Tea, Melissa R. Pitman, Julia R. Zebol, Paul A.B. Moretti, Heidi A. Neubauer, Brett W. Stringer, Bryan W. Day, Stuart M. Pitson, Jason A. Powell, Jasreen Kular, Michael S. Samuel
Publikováno v:
Oncogene
While the two mammalian sphingosine kinases, SK1 and SK2, both catalyze the generation of pro-survival sphingosine 1-phosphate (S1P), their roles vary dependent on their different subcellular localization. SK1 is generally found in the cytoplasm or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f1bf6cabe74c5c92b2081d06f30713
https://hdl.handle.net/11541.2/134345
https://hdl.handle.net/11541.2/134345
Autor:
Sarah T. Boyle, Alexander C. Lewis, Paul Timpson, Angel F. Lopez, Marina Kochetkova, Robert Whitfield, Jarrod J. Sandow, Natasha T. Pyne, Melinda N. Tea, Vinay Tergaonkar, Valentina Poltavets, Michael S. Samuel, Natasha Kolesnikoff, Stuart M. Pitson, Jasreen Kular, Andrew I. Webb, Kendelle J. Murphy, Paul A.B. Moretti
Publikováno v:
Nature Cell Biology. 22:908-908
Autor:
Paul Timpson, Max Nobis, Sarah T. Boyle, Andrew Ruszkiewicz, Jasreen Kular, Michael S. Samuel
Publikováno v:
Small GTPases
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The ability to rapidly respond to applied force underpins cell/tissue homeostasis. This response is mediated by mechanotransduction pathways that regulate remodeling and tension of the actomyosin cytoskeleton to counterbalance external forces. Enhanc
Non-severe burn injury leads to depletion of bone volume that can be ameliorated by inhibiting TNF-α
Publikováno v:
Burns. 41:558-564
Bone loss after severe burn injury is well established, and is thought to be a consequence of the severe hyper-metabolic response as well as changes in cytokine and glucocorticoid levels that decrease bone synthesis and increase rate of loss. However