Výsledky vyhledávání - "Jasper Verreet"

Anti-tumor efficacy of the novel KIT inhibitor IDRX-42 (formerly M4205) in patient- and cell line-derived xenograft models of gastrointestinal stromal tumor (GIST)

Autor: Luna De Sutter, Agnieszka Wozniak, Jasper Verreet, Ulla Vanleeuw, Lore De Cock, Nina Linde, Christine Drechsler, Christina Esdar, Raf Sciot, Patrick Schöffski

Publikováno v: Clinical Cancer Research.

Background: The majority of GIST are driven by constitutively activated KIT/PDGFRA kinases and are susceptible to treatment with tyrosine kinase inhibitors. During treatment, most of these tumors will develop secondary mutations in KIT or PDGFRA indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e05ed27f55451814e7178f785f5b3b2
https://doi.org/10.1158/1078-0432.ccr-22-3822

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Abstract 2666: Anti-tumor effects of the novel KIT mutant inhibitor M4205 in patient-derived gastrointestinal stromal tumor (GIST) xenograft models

Autor: Luna De Sutter, Agnieszka Wozniak, Jasper Verreet, Ulla Vanleeuw, Lore De Cock, Nina Linde, Christine Drechsler, Christina Esdar, Raf Sciot, Patrick Schöffski

Publikováno v: Cancer Research. 82:2666-2666

Background: The majority of GISTs are driven by constitutively activated KIT/PDGFRA kinases and susceptible to treatment with tyrosine kinase inhibitors such as imatinib, sunitinib and regorafenib. During treatment most tumors will develop heterogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c68d0970a3d4dd4cadea589972af2e3
https://doi.org/10.1158/1538-7445.am2022-2666

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