Výsledky vyhledávání - "Jasper M Morrow"

Akademický článek

Development of an initial training and evaluation programme for manual lower limb muscle MRI segmentation

Autor: Jasper M. Morrow, Sachit Shah, Lara Cristiano, Matthew R. B. Evans, Carolynne M. Doherty, Talal Alnaemi, Abeer Saab, Ahmed Emira, Uros Klickovic, Ahmed Hammam, Afnan Altuwaijri, Stephen Wastling, Mary M. Reilly, Michael G. Hanna, Tarek A. Yousry, John S. Thornton

Publikováno v: European Radiology Experimental, Vol 8, Iss 1, Pp 1-12 (2024)

Abstract Background Magnetic resonance imaging (MRI) quantification of intramuscular fat accumulation is a responsive biomarker in neuromuscular diseases. Despite emergence of automated methods, manual muscle segmentation remains an essential foundat

Externí odkaz: https://doaj.org/article/29a6b7777ec4436dbf62ecd5e9df90c4

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Akademický článek

Upper Limb Evaluation in Duchenne Muscular Dystrophy: Fat-Water Quantification by MRI, Muscle Force and Function Define Endpoints for Clinical Trials.

Autor: Valeria Ricotti, Matthew R B Evans, Christopher D J Sinclair, Jordan W Butler, Deborah A Ridout, Jean-Yves Hogrel, Ahmed Emira, Jasper M Morrow, Mary M Reilly, Michael G Hanna, Robert L Janiczek, Paul M Matthews, Tarek A Yousry, Francesco Muntoni, John S Thornton

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162542 (2016)

A number of promising experimental therapies for Duchenne muscular dystrophy (DMD) are emerging. Clinical trials currently rely on invasive biopsies or motivation-dependent functional tests to assess outcome. Quantitative muscle magnetic resonance im

Externí odkaz: https://doaj.org/article/19bd8f41fda140849f988d7494cfbc4e

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Akademický článek

Lower limb muscle MRI fat fraction is a responsive outcome measure in CMT X1, 1B and 2A

Publikováno v: Annals of Clinical and Translational Neurology, Vol 11, Iss 3, Pp 607-617 (2024)

Abstract Objective With potential therapies for many forms of Charcot‐Marie‐Tooth disease (CMT), responsive outcome measures are urgently needed for clinical trials. Quantitative lower limb MRI demonstrated progressive calf intramuscular fat accu

Externí odkaz: https://doaj.org/article/b655160e70c64a5fac42d356158f7451

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Akademický článek

Quantitative magnetic resonance imaging in limb-girdle muscular dystrophy 2I: a multinational cross-sectional study.

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e90377 (2014)

We conducted a prospective multinational study of muscle pathology using magnetic resonance imaging (MRI) in patients with limb-girdle muscular dystrophy 2I (LGMD2I). Thirty eight adult ambulant LGMD2I patients (19 male; 19 female) with genetically i

Externí odkaz: https://doaj.org/article/809289b1bcdc4a229f182469ffcb1256

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Akademický článek

Quantitative muscle MRI as an assessment tool for monitoring disease progression in LGMD2I: a multicentre longitudinal study.

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e70993 (2013)

Outcome measures for clinical trials in neuromuscular diseases are typically based on physical assessments which are dependent on patient effort, combine the effort of different muscle groups, and may not be sensitive to progression over short trial

Externí odkaz: https://doaj.org/article/52f1434bf16d451bb2e6f4224e501642

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Akademický článek

Muscle magnetic resonance imaging involvement patterns in nemaline myopathies

Autor: Luke Perry, Georgia Stimpson, Leeha Singh, Jasper M. Morrow, Sachit Shah, Giovanni Baranello, Francesco Muntoni, Anna Sarkozy

Publikováno v: Annals of Clinical and Translational Neurology, Vol 10, Iss 7, Pp 1219-1229 (2023)

Abstract Objective Characterise the diagnostic and prognostic value of muscle MRI patterns as biomarkers in a genetically heterogeneous nemaline myopathy (NM) patient cohort. Methods Modified Mercuri scoring of lower limb MRI in genetically character

Externí odkaz: https://doaj.org/article/27f9a36c99974d868cd782ce561793a9

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Akademický článek

Integrin α7 Mutations Are Associated With Adult‐Onset Cardiac Dysfunction in Humans and Mice

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 23 (2022)

Background Integrin α7β1 is a major laminin receptor in skeletal and cardiac muscle. In skeletal muscle, integrin α7β1 plays an important role during muscle development and has been described as an important modifier of skeletal muscle diseases.

Externí odkaz: https://doaj.org/article/350a26baecc8491eac3c63f5cd504fe7

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Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI

Autor: Mostafa Elmansy, Jasper M. Morrow, Sachit Shah, Arne Fischmann, Stephen Wastling, Mary M. Reilly, Michael G. Hanna, Eman Mohamed Helmy, Saleh Saleh El‐Essawy, John S. Thornton, Tarek A. Yousry

Publikováno v: MusclenerveREFERENCES. 66(6)

Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length-dependent polyneuropathy. In this study, we quantified the cross-sectional area of the sciatic and tibial nerves in patients with IB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a98b6f4e4f7b1bc4e8986ff6307671
https://pubmed.ncbi.nlm.nih.gov/36151728

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