Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jasper G. van den Boorn"'
Autor:
Silke Lambing, Yu Pan Tan, Paraskevi Vasileiadou, Stefan Holdenrieder, Patrick Müller, Christian Hagen, Stephan Garbe, Rayk Behrendt, Martin Schlee, Jasper G van den Boorn, Eva Bartok, Marcel Renn, Gunther Hartmann
Publikováno v:
Journal of Molecular Cell Biology.
Radiotherapy induces DNA damage, resulting in cell-cycle arrest and activation of cell-intrinsic death pathways. However, radioresistance of some tumor entities such as malignant melanoma limits its clinical application. The innate immune sensing rec
Autor:
Stefan Holdenrieder, Stephan Garbe, Jasper G. van den Boorn, Marcel Renn, Christian Hagen, Gunther Hartmann, Martin Schlee, Eva Bartok, Patrick Müller, Silke Lambing
Radiation therapy induces cytotoxic DNA damage, which results in cell-cycle arrest and activation of cell-intrinsic death pathways, but its application has been limited by the radioresistance of tumors, such as in malignant melanoma. RIG-I is a cytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6845c290d1b6dd755adc713f73ba9f
https://doi.org/10.1101/2021.10.16.464638
https://doi.org/10.1101/2021.10.16.464638
Autor:
Jasper G van den Boorn, Debby Konijnenberg, Esther P M Tjin, Daisy I Picavet, Nico J Meeuwenoord, Dmitri V Filippov, J P Wietze van der Veen, Jan D Bos, Cornelis J M Melief, Rosalie M Luiten
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10626 (2010)
Presently melanoma still lacks adequate treatment options for metastatic disease. While melanoma is exceptionally challenging to standard regimens, it is suited for treatment with immunotherapy based on its immunogenicity. Since treatment-related ski
Externí odkaz:
https://doaj.org/article/46314c5ab5e149b893249a1b52bd1621
Autor:
Gunther Hartmann, Veit Hornung, Christian Hagen, Christopher Jakobs, Jasper G. van den Boorn, Marcel Renn, Thomas Tüting, Natalio Garbi, Cornelis J. M. Melief, Rosalie M. Luiten
Publikováno v:
Immunity, 44(6), 1406-1421. Cell Press
Summary Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of c
Publikováno v:
Immunity. 39(1):27-37
Immunotherapy of cancer must be effective in the pre-established disease; i.e., in the therapeutic rather than prophylactic setting. Here, we review novel immunotherapeutic approaches for targeting established cancers. In addition to novel checkpoint
Publikováno v:
Advanced Drug Delivery Reviews. 65:331-335
Exosomes are nano-sized vesicles produced naturally by many cell types. They are specifically loaded with nucleic acid cargo, dependent on the exosome-producing cell and its homeostatic state. As natural intercellular shuttles of miRNA, exosomes infl
Autor:
Silke Lambing, Janos Ludwig, Dorottya Horváth, Daniela Wenzel, Veit Hornung, Samira Marx, Jan W. Drijfhout, Christina Engel, Larissa H. Mühlenbeck, Gunther Hartmann, Christoph Coch, Martin Schlee, Jasper G. van den Boorn, Grethe Brügmann, Christian Hagen, Marion Goldeck, Thomas Tüting, Anna-Maria Herzner
Publikováno v:
Cancer Immunology Research, 5(6), 455-467
A hypoxic tumor microenvironment is linked to poor prognosis. It promotes tumor cell dedifferentiation and metastasis and desensitizes tumor cells to type-I IFN, chemotherapy, and irradiation. The cytoplasmic immunoreceptor retinoic acid-inducible ge
Publikováno v:
Pigment Cell & Melanoma Research. 24:673-679
Summary Autoimmune side-effects such as vitiligo regularly occur during melanoma immunotherapy. As vitiligo development is associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent
Autor:
Cornelis J. M. Melief, Paul F. van Swieten, Daisy I. Picavet, Toni M.M. van Capel, Esther C. de Jong, Rosalie M. Luiten, Jasper G. van den Boorn, Peter A. van Veelen, Eric Reits, Jan D. Bos, Henk A. van Veen, Debby Konijnenberg, Jan W. Drijfhout
Publikováno v:
Journal of investigative dermatology, 131(6), 1240-1251. Nature Publishing Group
Journal of Investigative Dermatology, 131(6), 1240-1251
Journal of Investigative Dermatology, 131(6), 1240-1251
In this study, we report the previously unknown mechanism of inducing robust anti-melanoma immunity by the vitiligo-inducing compound monobenzone. We show monobenzone to increase melanocyte and melanoma cell immunogenicity by forming quinone-haptens
Publikováno v:
Molecular Therapy. 22(9):1577-1579
Macrophage colony-stimulating factor 1 (CSF1) is a hematopoietic growth factor involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. Current clinical interest in CSF1 lies in relativ