Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jasper C Lin"'
Autor:
Jasper C Lin, Ruth A Ettinger, Jason T Schuman, Ai-Hong Zhang, Muhammad Wamiq-Adhami, Phuong-Cac T Nguyen, Shelley M Nakaya-Fletcher, Komal Puranik, Arthur R Thompson, Kathleen P Pratt
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116577 (2015)
The development of neutralizing anti-factor VIII (FVIII) antibodies complicates the treatment of many hemophilia A patients. The C-terminal C2 domain is a particularly antigenic FVIII region. A crystal structure of recombinant FVIII-C2 bound to an Fa
Externí odkaz:
https://doaj.org/article/9f01ce1acfea4daca262cfb00998c208
Autor:
Rushd Khalaf, Neil Mody, Bruno F. Marques, Steven M. Cramer, Christopher D. Afdahl, Richard C. Willson, Jennifer M. Pollard, Eike Zimmermann, Jan Griesbach, Divya Chandra, Charles A. Haynes, Kannan Sankar, Ujwal Patil, Jonathan Coffman, Hasan Mohammad, Joelle Khouri, Minni Aswath, Jasper C. Lin, Lars Pampel, Alexander Hanke, Siddharth Parimal, David J. Roush, Francis Insaidoo, Saeed Izadi, Raquel Orozco, Soundara Soundararajan, Nihal Tugcu, Gisela Ferreira, Tingting Cui, John P. Welsh, Jainik Panchal, Ambrose Williams, Stefan Hepbildikler, Xuan Hong, Julie Robinson, Marco A. Blanco, John E. Schiel, Jared A. Delmar, Benjamin T. Walters
Publikováno v:
Biotechnology and Bioengineering. 117:2100-2115
Biopharmaceutical product and process development do not yet take advantage of predictive computational modeling to nearly the degree seen in industries based on smaller molecules. To assess and advance progress in this area, spirited coopetition (mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691f1fe3ec2b1fe3233cd79e9f3b84d
https://doi.org/10.1002/bit.27349
https://doi.org/10.1002/bit.27349
Autor:
George M. Bou-Assaf, Ivan L. Budyak, Michael Brenowitz, Eric S. Day, David Hayes, John Hill, Ranajoy Majumdar, Paola Ringhieri, Peter Schuck, Jasper C. Lin
Publikováno v:
J Pharm Sci
Analytical ultracentrifugation (AUC) is a critical analytical tool supporting the development and manufacture of protein therapeutics. AUC is routinely used as an assay orthogonal to size exclusion chromatography for aggregate quantitation. This arti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e43b967f463b00c953dcfcd1b5533d9
https://europepmc.org/articles/PMC9232890/
https://europepmc.org/articles/PMC9232890/
Deamidation of asparagine (ASN) and isomerization of aspartic acid (ASP) residues are among the most commonly observed spontaneous post-translational modifications (PTMs) in proteins. Understanding and predicting a protein sequence’s propensity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9092b3d947c03dcded88e7098f42e84a
https://doi.org/10.1101/2021.07.26.453885
https://doi.org/10.1101/2021.07.26.453885
Publikováno v:
Pharmaceutical Research. 37
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceutical formulations, can undergo hydrolytic degradation resulting in free fatty acids (FFAs) that precipitate to form particles. This work investigates the ability for silicone oil (si-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7881850840283cedd46431687b3d3a9c
https://doi.org/10.1007/s11095-020-02936-3
https://doi.org/10.1007/s11095-020-02936-3
Autor:
Camille L. Bilodeau, Giorgio Carta, Eric von Lieres, Steve Benner, Deenesh Kavi Babi, Philipp Ernst, Oleksandr Zavalov, John P. Welsh, Jan Griesbach, Marcel Stenvang, Larry Sun, Ernst Broberg Hansen, Arne Staby, S. Hunt, Thomas Wucherpfennig, Emmanouil Papadakis, Dilip Asthagiri, Matthew Flamm, Mark Fedesco, Sean Fitzgibbon, Bruno F. Marques, David J. Roush, Jasper C. Lin, Richard C. Willson, Fabrice Schlegel, Francis Insaidoo, Henrik S. Marke, Gang Wang, Tobias Grosskopf, Abraham M. Lenhoff, Peter M. Tessier, Tobias Hahn, R. Todd
Publikováno v:
Biotechnology & bioengineering 117(12), 3986-4000 (2020). doi:10.1002/bit.27520
The Third Modeling Workshop focusing on bioprocess modeling was held in Kenilworth, NJ in May 2019. A summary of these Workshop proceedings is captured in this manuscript. Modeling is an active area of research within the biotechnology community, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439240129d8f91f7f1d2274d485c9aa6
https://hdl.handle.net/2128/27001
https://hdl.handle.net/2128/27001
Publikováno v:
The Journal of Physical Chemistry B. 122:2368-2378
One-dimensional heteronuclear relaxation dispersion NMR spectroscopy at 13C natural abundance successfully characterized the dynamics of the hydrogen–deuterium exchange reaction occurring at the Ne position in l-arginine by monitoring Cδ in varyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afdb08d303e7d5f5c9c6f7989db3ac0
https://doi.org/10.1021/acs.jpcb.7b10849
https://doi.org/10.1021/acs.jpcb.7b10849
Publikováno v:
Robotica. 32:401-411
SUMMARYSingularity-free workspace is a very important criterion for the design of manipulators, especially for parallel manipulators which are well known for their limited workspace and complex singularities. This paper studies geometric parameters a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca802fa83b31320e8c4ff34d22076ad0
https://doi.org/10.1017/s0263574713000672
https://doi.org/10.1017/s0263574713000672
Autor:
Jasper C. Lin, P. J. Hore, Niels H. Andersen, Martin Goez, K. Hun Mok, Lars T. Kuhn, Iain J. Day
Insights into the conformational passage of a polypeptide chain across its free energy landscape have come from the judicious combination of experimental studies and computer simulations1,2. Even though some unfolded and partially folded proteins are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd4aa82a3dd45ffc1a0254b05527d2b
https://doi.org/10.1038/nature05728
https://doi.org/10.1038/nature05728
Publikováno v:
Journal of pharmaceutical sciences. 104(12)
Protein characterization is a necessary activity during development, technical transfers, and licensure. One important aspect of protein characterization is higher order structure assessment, which can be accomplished in a variety of ways. Circular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a50ac6a814cd94847bb7cb73d13a08
https://pubmed.ncbi.nlm.nih.gov/26505267
https://pubmed.ncbi.nlm.nih.gov/26505267