Výsledky vyhledávání - "Jasper B. Olsem"

Akademický článek

Personalized neoantigen vaccines as early intervention in untreated patients with lymphoplasmacytic lymphoma: a non-randomized phase 1 trial

Autor: Szymon J. Szymura, Lin Wang, Tiantian Zhang, Soung-chul Cha, Joo Song, Zhenyuan Dong, Aaron Anderson, Elizabeth Oh, Vincent Lee, Zhe Wang, Sapna Parshottam, Sheetal Rao, Jasper B. Olsem, Brandon N. Crumpton, Hans C. Lee, Elisabet E. Manasanch, Sattva Neelapu, Larry W. Kwak, Sheeba K. Thomas

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Lymphoplasmacytic lymphoma (LPL) is an incurable low-grade lymphoma with no standard therapy. Nine asymptomatic patients treated with a first-in-human, neoantigen DNA vaccine experienced no dose limiting toxicities (primary endpoint, NCT0120

Externí odkaz: https://doaj.org/article/b4cc18ce434b4c7584d647c8e9b7b29b

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Phase I/Ib study of carfilzomib and panobinostat with or without dexamethasone in patients with relapsed/refractory multiple myeloma

Autor: Sheeba K. Thomas, Ashley Morphey, Donna M. Weber, Robert Z. Orlowski, Jatin J. Shah, Brandon N. Crumpton, Zuzana Berkova, Jasper B. Olsem, Behrang Amini, Lei Feng, Hans C. Lee, Elisabet E. Manasanch

Publikováno v: Haematologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876ebb80901a504dece6d1634e38af82
https://doi.org/10.3324/haematol.2019.225375

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Safety and Efficacy of Combination Maintenance Therapy with Ixazomib and Lenalidomide in Post-Transplant Myeloma Patients

Autor: Elisabet E. Manasanch, Donna M. Weber, Muzaffar H. Qazilbash, Robert Z. Orlowski, Krina K. Patel, Hans C. Lee, Qaiser Bashir, Jatin J. Shah, Sheeba K. Thomas, Ashley Morphey, Jasper B. Olsem, Xiao Jiao Huo, Lei Feng

Publikováno v: Blood. 138:4774-4774

Backrground: Several randomized controlled clinical trials have demonstrated improved outcomes for newly diagnosed multiple myeloma (NDMM) patients who were treated with lenalidomide as maintenance therapy after autologous stem cell transplant (ASCT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27933ea36fdd6163d379be57f228e1fc
https://doi.org/10.1182/blood-2021-151950

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A Novel Therapeutic DNA Vaccine Elicits Reduction of Tumor Clones and Favorable Perturbations in the Immune Microenvironment in Patients (pts) with Untreated Smoldering Waldenström Macroglobulinemia (sWM)

Autor: Aaron Anderson, Sattva S. Neelapu, Zhe Wang, Donna M. Weber, Soung-chul Cha, Elisabet E. Manasanch, Sheeba K. Thomas, Lei Feng, Hans C. Lee, Szymon Jakub Szymura, Robert Z. Orlowski, Brandon N. Crumpton, Larry W. Kwak, Sheetal S Rao, Jasper B. Olsem, Sapna R. Parshottam, Krina K. Patel

Publikováno v: Blood. 136:6-7

Background: Idiotypic determinants of the surface immunoglobulin (Ig) associated with a given pt's B-cell lymphoma are unique to that tumor, and can thus serve as a tumor-specific marker. This study aims to use an idiotype DNA vaccine to lengthen the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::356d03a4795dceaa90dae80842583350
https://doi.org/10.1182/blood-2020-140007

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