Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jasper Akerboom"'
Autor:
Kirk J. Czymmek, Seogchan Kang, Hokyoung Son, Hye-Seon Kim, Aram Hwangbo, Randall L. Duncan, Jasper Akerboom, Jung Eun Kim, Loren L. Looger
Genetically encoded Ca2+ indicators (GECIs) enable long-term monitoring of cellular and subcellular dynamics of this second messenger in response to environmental and developmental cues without relying on exogenous dyes. Continued development and opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ff01b0bbd5de3c8746fc2cea8f598b
https://escholarship.org/uc/item/08g6r3bh
https://escholarship.org/uc/item/08g6r3bh
Autor:
Hye-Seon, Kim, Jung-Eun, Kim, Aram, Hwangbo, Jasper, Akerboom, Loren L, Looger, Randall, Duncan, Hokyoung, Son, Kirk J, Czymmek, Seogchan, Kang
Publikováno v:
Fungal genetics and biology : FGB. 149
Genetically encoded Ca
Autor:
Andrei Tokmakoff, Alipasha Vaziri, Jasper Akerboom, Carlos R. Baiz, Christoph Götz, Paul G. Stevenson
Publikováno v:
The Journal of Physical Chemistry. B
The effect of ion binding in the selectivity filter of the potassium channel KcsA is investigated by combining amide I Fourier-transform infrared spectroscopy with structure-based spectral modeling. Experimental difference IR spectra between K(+)-bou
Autor:
Roland Benz, Markus Zweckstetter, Loren L. Looger, Sebastian Kügler, Pauline Wales, Mathias Bähr, Johan Toloe, Julia Tereshchenko, Stefan Becker, Tiago F. Outeiro, Grit Taschenberger, Jasper Akerboom
Publikováno v:
Annals of Neurology. 74:109-118
Objective Whereas the contribution of α-synuclein to neurodegeneration in Parkinson disease is well accepted, the putative impact of its close homologue, β-synuclein, is enigmatic. β-Synuclein is widely expressed throughout the central nervous sys
Autor:
Eiji Shigetomi, Sevinç Mutlu, Andrew Gordus, Florian Engert, Loren L. Looger, John J. Macklin, Eric R. Schreiter, Aman Aggarwal, Nicole Carreras Calderón, Bruce E. Kimmel, Samuel S.-H. Wang, Douglas S. Kim, Herwig Baier, Leon Lagnado, Sebastian Kracun, Karel Svoboda, Baljit S. Khakh, Xiaonan Richard Sun, Trevor J. Wardill, Ruben Portugues, Lin Tian, Cornelia I. Bargmann, Vivek Jayaraman, Federico Esposti, Bart G. Borghuis, Jonathan S. Marvin, Alessandro Filosa, Tsai Wen Chen, Ryousuke Takagi, Michael B. Orger, Jasper Akerboom, Rex Kerr
Publikováno v:
The Journal of Neuroscience. 32:13819-13840
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been dep
Autor:
S. Andrew Hires, Eric R. Schreiter, Karel Svoboda, Leopoldo Petreanu, Cornelia I. Bargmann, Lin Tian, Sean A McKinney, M. Eugenia Chiappe, Vivek Jayaraman, Loren L. Looger, Tianyi Mao, Sreekanth H. Chalasani, Jasper Akerboom, Daniel Huber
Publikováno v:
Nature methods
Genetically encoded calcium indicators (GECIs) can be used to image activity in defined neuronal populations. However, current GECIs produce inferior signals compared to synthetic indicators and recording electrodes, precluding detection of low firin
Autor:
Jonathan S. Marvin, Elisa C. Alfaro Malave, Lin Tian, Loren L. Looger, Jonathan D. Velez Rivera, Eric R. Schreiter, Hector H. Hernandez, S. Andrew Hires, Jasper Akerboom, María M. Rodríguez Guilbe
Publikováno v:
The Journal of Biological Chemistry
The genetically encoded calcium indicator GCaMP2 shows promise for neural network activity imaging, but is currently limited by low signal-to-noise ratio. We describe x-ray crystal structures as well as solution biophysical and spectroscopic characte
Autor:
Tamotsu Kanai, Haruyuki Atomi, Harmen J.G. van de Werken, Tadayuki Imanaka, Jasper Akerboom, Taira Murakami, Shogo Takedomi, John van der Oost, Fabian Blombach
Publikováno v:
Journal of Biological Chemistry, 282(46), 33659-33670
Journal of Biological Chemistry 282 (2007) 46
Journal of Biological Chemistry, 282(46), 33659-33670. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry 282 (2007) 46
Journal of Biological Chemistry, 282(46), 33659-33670. American Society for Biochemistry and Molecular Biology Inc.
We identified a novel regulator, Thermococcales glycolytic regulator (Tgr), functioning as both an activator and a repressor of transcription in the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1. Tgr (TK1769) displays similarity (28% ide
Autor:
John van der Oost, Andrew P. Turnbull, Jasper Akerboom, Stan J. J. Brouns, Hanneke L.D.M. Willemen
Publikováno v:
Journal of Molecular Biology 371 (2007) 5
Journal of Molecular Biology, 371(5), 1249-1260
Journal of Molecular Biology, 371(5), 1249-1260
Sulfolobus solfataricus metabolizes the five-carbon sugar d-arabinose to 2-oxoglutarate by an inducible pathway consisting of dehydrogenases and dehydratases. Here we report the crystal structure and biochemical properties of the first enzyme of this
Autor:
Andrew P. Turnbull, John van der Oost, Willem M. de Vos, Hao Wu, Stan J. J. Brouns, Jasper Akerboom
Publikováno v:
Journal of Biological Chemistry, 280(12), 11422-11431
Journal of Biological Chemistry 280 (2005) 12
Journal of Biological Chemistry 280 (2005) 12
Limited thermostability of antibiotic resistance markers has restricted genetic research in the field of extremely thermophilic Archaea and bacteria. In this study, we used directed evolution and selection in the thermophilic bacterium Thermus thermo